Abstract
Glioblastoma
is
one
of
the
most
aggressive
central
nervous
system
malignancies
with
high
morbidity
and
mortality.
Current
clinical
approaches,
including
surgical
resection,
radiotherapy,
chemotherapy,
are
limited
by
difficulty
targeting
brain
lesions
accurately,
leading
to
disease
recurrence
fatal
outcomes.
The
lack
effective
treatments
has
prompted
researchers
continuously
explore
novel
therapeutic
strategies.
In
recent
years,
nanomedicine
made
remarkable
progress
expanded
its
application
in
drug
delivery,
providing
a
new
treatment
for
tumors.
Against
this
background,
article
reviews
delivery
systems
paper,
mechanism
nanomaterials
crossing
blood‐brain
barrier
summarized.
Furthermore,
specific
nanotechnology
glioblastoma
discussed
depth.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(23)
Опубликована: Март 6, 2023
Abstract
It
is
an
urgent
need
that
defect
repair
can
develop
from
simple
device
fixation
to
living
tissue
reconstruction,
short
life
function
replacement
permanent
regeneration
repair.
At
present,
bone
transplantation
has
become
the
second
largest
surgery
after
blood
transfusion,
and
artificial
generates
great
hope
for
treatment
of
defect.
In
order
defect,
must
have
good
biological
properties
sufficient
mechanical
properties,
it
should
also
shape
matching
site
connected
porous
structure.
For
structures
requirements
bone,
in
this
review
three
major
challenges
faced
by
are
systemtically
analyzed
current
methods
strategies
address
these
issues
discussed:
1)
developing
a
type
scaffold
material
with
both
2)
realizing
controllable
fabrication
individual
multistage
pore
structure
scaffold,
3)
transformation
man‐made
Besides,
summarizes
advantages
disadvantages
discusses
potential
future
directions
structural
functional
adaptive
regeneration.
Nano Letters,
Год журнала:
2021,
Номер
21(19), С. 8281 - 8289
Опубликована: Сен. 30, 2021
Pyroptosis,
which
is
a
mode
of
programmed
cell
death,
has
proven
effective
for
cancer
therapy.
However,
efficient
pyroptosis
inducers
tumor
treatment
are
limited.
This
study
proposes
biodegradable
K3ZrF7:Yb/Er
upconversion
nanoparticles
(ZrNPs)
as
immunotherapy.
ZrNPs,
similar
to
ion
reservoirs,
can
be
dissolved
inside
cells
and
release
high
amounts
K+
[ZrF7]3-
ions,
resulting
surge
in
intracellular
osmolarity
homeostasis
imbalance.
further
induces
an
increase
reactive
oxygen
species
(ROS),
caspase-1
protein
activation,
gasdermin
D
(GSDMD)
cleavage,
interleukin-1β
(IL-1β)
maturity,
results
cytolysis.
In
vivo
tests
confirm
that
ZrNPs-induced
exhibits
superior
antitumor
immunity
activity
confirmed
by
enhanced
dendritic
(DCs)
maturity
frequency
effector-memory
T
cells,
well
observably
inhibiting
growth
pulmonary
metastasis.
work
believed
extend
the
biomedical
applications
nanomaterials
deepen
understanding
intrinsic
immunomodulatory
nanomaterials.
ACS Nano,
Год журнала:
2021,
Номер
15(7), С. 11428 - 11440
Опубликована: Июнь 21, 2021
Fenton-like
reactions
driven
by
manganese-based
nanostructures
have
been
widely
applied
in
cancer
treatment
owing
to
the
intrinsic
physiochemical
properties
of
these
and
their
improved
sensitivity
tumor
microenvironment.
In
this
work,
ZnxMn1–xS@polydopamine
composites
incorporating
alloyed
ZnxMn1–xS
polydopamine
(PDA)
were
constructed,
which
Mn
ions
can
be
tuned
a
controllable
release
vitro
vivo.
As
result,
ZnxMn1–xS@PDA
exhibited
good
biocompatibility
with
normal
cells
but
was
specifically
toxic
cells.
addition,
shell
thickness
PDA
carefully
investigated
obtain
excellent
specific
toxicity
promote
synergistic
chemodynamic
photothermal
therapies.
Overall,
work
highlights
an
alternative
strategy
for
fabricating
high-performance,
multifunctional
composite
combined
treatment.
Advanced Materials,
Год журнала:
2023,
Номер
36(8)
Опубликована: Окт. 11, 2023
Abstract
Activating
the
strong
immune
system
is
a
key
initiative
to
counteract
dormant
tumors
and
prevent
recurrence.
Herein,
self‐destructive
multienzymatically
active
copper‐quinone‐GOx
nanoparticles
(abbreviated
as
CQG
NPs)
have
been
designed
induce
harmonious
balanced
pyroptosis
cuproptosis
using
“Tai
Chi
mindset”
awaken
response
for
suppressing
recurrent
tumors.
This
cleverly
material
can
disrupt
antioxidant
defense
mechanism
of
tumor
cells
by
inhibiting
nuclear
factor‐erythroid
2‐related
factor
2
(NRF2)‐quinone
oxidoreductase
1
(NQO1)
signaling
pathway.
Furthermore,
combined
with
its
excellent
multienzyme
activity,
it
activates
NOD‐like
receptor
protein
3
(NLRP3)‐mediated
pyroptosis.
Meanwhile,
be
triggered
copper
ions
released
from
disintegration
NPs
sensitivity
cancer
enhanced
through
depletion
endogenous
chelators
via
Michael
addition
reaction
between
glutathione
(GSH)
quinone
ligand,
oxygen
production
catalase‐like
reaction,
starvation‐induced
glucose
deficiency.
More
importantly,
NPs‐induced
promote
immunosuppressive
microenvironment
(TME)
remodeling,
enhance
infiltration
into
tumor,
activate
robust
systemic
immunity.
Collectively,
this
study
provides
new
strategy
resist
dormancy,
recurrence,
improve
clinical
prognosis
ACS Nano,
Год журнала:
2023,
Номер
17(9), С. 7953 - 7978
Опубликована: Апрель 18, 2023
Hydrogels,
as
one
of
the
most
feasible
soft
biomaterials,
have
gained
considerable
attention
in
therapeutic
applications
by
virtue
their
tunable
properties
including
superior
patient
compliance,
good
biocompatibility
and
biodegradation,
high
cargo-loading
efficiency.
However,
hydrogel
application
is
still
limited
some
challenges
like
inefficient
encapsulation,
easy
leakage
loaded
cargoes,
lack
controllability.
Recently,
nanoarchitecture-integrated
systems
were
found
to
be
therapeutics
with
optimized
properties,
extending
bioapplication.
In
this
review,
we
briefly
presented
category
hydrogels
according
synthetic
materials
further
discussed
advantages
Additionally,
various
nanoarchitecture
hybrid
biomedical
engineering
are
systematically
summarized,
cancer
therapy,
wound
healing,
cardiac
repair,
bone
regeneration,
diabetes
obesity
therapy.
Last,
current
challenges,
limitations,
future
perspectives
development
flexible
addressed.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(24)
Опубликована: Апрель 22, 2023
Chronic
nonhealing
diabetic
wounds
are
becoming
increasingly
severe,
with
high
rates
of
mortality
and
disability,
owing
to
the
difficulty
in
wound
healing
caused
by
hyperglycemia,
blocked
angiogenesis,
biofilm
infection,
excessive
oxidative
stress.
A
multicomponent
enzyme-responsive
natural
polymer,
a
hyaluronic
acid
(HA)
microneedle,
embedded
cerium/zinc-based
nanomaterial
(ZCO)
for
treatment
is
reported.
ZCO-HA
can
destroy
oxidation
balance
bacteria,
kill
scavenge
reactive
oxygen
species
(ROS)
alleviate
stress
via
adjustable
release
Zn2+
Ce3+
/4+
.
Additionally,
exhibits
good
anti-inflammatory
activity
through
nuclear
factor
kappa-B
(NF-κB)
pathway,
which
reduces
inflammatory
state
macrophages
promotes
cell
proliferation,
migration,
angiogenesis.
In
vitro
experiments
shows
that
accompanies
mouse
fibroblast
promoting
human
umbilical
vein
endothelial
tube
formation.
vivo
studies
mice
streptozotocin-induced
(STZ)-induced
diabetes
reveal
this
microneedle
accelerates
without
systemic
toxicity.
RNA
transcriptome
sequencing
illustrates
HA
migration
inhibits
reactions
damage
NF-κB
signaling
pathway.
