A nanoscale genosensor for early detection of COVID-19 by voltammetric determination of RNA-dependent RNA polymerase (RdRP) sequence of SARS-CoV-2 virus DOI Creative Commons

Leila Farzin,

Sodeh Sadjadi,

Azarmidokht Sheini

и другие.

Microchimica Acta, Год журнала: 2021, Номер 188(4)

Опубликована: Март 10, 2021

A voltammetric genosensor has been developed for the early diagnosis of COVID-19 by determination RNA-dependent RNA polymerase (RdRP) sequence as a specific target novel coronavirus. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) uses an RdRP replication its genome and transcription genes. Here, silver ions (Ag+) in hexathia-18-crown-6 (HT18C6) were used first time redox probe. Then, HT18C6(Ag) incorporated carbon paste electrode (CPE) was further modified with chitosan PAMAM dendrimer-coated silicon quantum dots (SiQDs@PAMAM) immobilization probe sequences (aminated oligonucleotides). current intensity differential pulse voltammetry using found to decrease increasing concentration sequence. Based on such signal-off trend, proposed exhibited good linear response SARS-CoV-2 range 1.0 pM–8.0 nM regression equation I (μA) = − 6.555 log [RdRP sequence] (pM) + 32.676 (R2 0.995) limit detection (LOD) 0.3 pM. standard addition method different spike concentrations human sputum samples showed recovery real sample analysis (> 95%). Therefore, can be determine samples.

Язык: Английский

Technology Roadmap for Flexible Sensors DOI Creative Commons
Yifei Luo, Mohammad Reza Abidian, Jong‐Hyun Ahn

и другие.

ACS Nano, Год журнала: 2023, Номер 17(6), С. 5211 - 5295

Опубликована: Март 9, 2023

Humans rely increasingly on sensors to address grand challenges and improve quality of life in the era digitalization big data. For ubiquitous sensing, flexible are developed overcome limitations conventional rigid counterparts. Despite rapid advancement bench-side research over last decade, market adoption remains limited. To ease expedite their deployment, here, we identify bottlenecks hindering maturation propose promising solutions. We first analyze achieving satisfactory sensing performance for real-world applications then summarize issues compatible sensor-biology interfaces, followed by brief discussions powering connecting sensor networks. Issues en route commercialization sustainable growth sector also analyzed, highlighting environmental concerns emphasizing nontechnical such as business, regulatory, ethical considerations. Additionally, look at future intelligent sensors. In proposing a comprehensive roadmap, hope steer efforts towards common goals guide coordinated development strategies from disparate communities. Through collaborative efforts, scientific breakthroughs can be made sooner capitalized betterment humanity.

Язык: Английский

Процитировано

682

Skin-Interfaced Wearable Sweat Sensors for Precision Medicine DOI
Jihong Min, Jiaobing Tu, Changhao Xu

и другие.

Chemical Reviews, Год журнала: 2023, Номер 123(8), С. 5049 - 5138

Опубликована: Март 27, 2023

Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward healthcare. Advances flexible electronics, materials science, electrochemistry have spurred the development of wearable sweat that enable continuous noninvasive screening analytes indicative status. Existing major challenges include: improving extraction sensing capabilities, form factor device for minimal discomfort reliable measurements when worn, understanding clinical value biomarker discovery. This review provides a comprehensive outlines state-of-the-art technologies research strive to bridge these gaps. The physiology sweat, materials, biosensing mechanisms advances, approaches induction sampling are introduced. Additionally, design considerations system-level devices, spanning from strategies prolonged efficient powering wearables, discussed. Furthermore, applications, data commercialization efforts, challenges, prospects precision medicine

Язык: Английский

Процитировано

318

A Review of the Role of Artificial Intelligence in Healthcare DOI Open Access
Ahmed Al Kuwaiti,

Khalid Nazer,

Abdullah H. Alreedy

и другие.

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(6), С. 951 - 951

Опубликована: Июнь 5, 2023

Artificial intelligence (AI) applications have transformed healthcare. This study is based on a general literature review uncovering the role of AI in healthcare and focuses following key aspects: (i) medical imaging diagnostics, (ii) virtual patient care, (iii) research drug discovery, (iv) engagement compliance, (v) rehabilitation, (vi) other administrative applications. The impact observed detecting clinical conditions diagnostic services, controlling outbreak coronavirus disease 2019 (COVID-19) with early diagnosis, providing care using AI-powered tools, managing electronic health records, augmenting compliance treatment plan, reducing workload professionals (HCPs), discovering new drugs vaccines, spotting prescription errors, extensive data storage analysis, technology-assisted rehabilitation. Nevertheless, this science pitch meets several technical, ethical, social challenges, including privacy, safety, right to decide try, costs, information consent, access, efficacy, while integrating into governance crucial for safety accountability raising HCPs' belief enhancing acceptance boosting significant consequences. Effective prerequisite precisely address regulatory, trust issues advancing implementation AI. Since COVID-19 hit global system, concept has created revolution healthcare, such an uprising could be another step forward meet future needs.

Язык: Английский

Процитировано

314

Ambulatory Cardiovascular Monitoring Via a Machine‐Learning‐Assisted Textile Triboelectric Sensor DOI
Yunsheng Fang, Yongjiu Zou, Jing Xu

и другие.

Advanced Materials, Год журнала: 2021, Номер 33(41)

Опубликована: Авг. 31, 2021

Abstract Wearable bioelectronics for continuous and reliable pulse wave monitoring against body motion perspiration remains a great challenge highly desired. Here, low‐cost, lightweight, mechanically durable textile triboelectric sensor that can convert subtle skin deformation caused by arterial pulsatility into electricity high‐fidelity waveform in an ambulatory sweaty setting is developed. The holds signal‐to‐noise ratio of 23.3 dB, response time 40 ms, sensitivity 0.21 µA kPa −1 . With the assistance machine learning algorithms, continuously precisely measure systolic diastolic pressure, accuracy validated via commercial blood pressure cuff at hospital. Additionally, customized cellphone application (APP) based on built‐in algorithm developed one‐click health data sharing data‐driven cardiovascular diagnosis. enabled wireless biomonitoring system expected to offer practical paradigm personalized characterization era Internet Things.

Язык: Английский

Процитировано

300

Multifunctional Flexible Humidity Sensor Systems Towards Noncontact Wearable Electronics DOI Creative Commons
Yuyao Lu, Geng Yang, Yajing Shen

и другие.

Nano-Micro Letters, Год журнала: 2022, Номер 14(1)

Опубликована: Июль 22, 2022

In the past decade, global industry and research attentions on intelligent skin-like electronics have boosted their applications in diverse fields including human healthcare, Internet of Things, human-machine interfaces, artificial intelligence soft robotics. Among them, flexible humidity sensors play a vital role noncontact measurements relying unique property rapid response to change. This work presents an overview recent advances using various active functional materials for contactless monitoring. Four categories are highlighted based resistive, capacitive, impedance-type voltage-type working mechanisms. Furthermore, typical strategies chemical doping, structural design Joule heating introduced enhance performance sensors. Drawing perception capability, human/plant healthcare management, interactions as well integrated sensor-based feedback systems presented. The burgeoning innovations this field will benefit society, especially during COVID-19 epidemic, where cross-infection should be averted sensation is highly desired.

Язык: Английский

Процитировано

206

Self-Powered Wearable Biosensors DOI
Yu Song, Daniel Mukasa, Haixia Zhang

и другие.

Accounts of Materials Research, Год журнала: 2021, Номер 2(3), С. 184 - 197

Опубликована: Фев. 14, 2021

ConspectusWearable biosensors hold the potential of revolutionizing personalized healthcare and telemedicine. Advances in chemical sensing, flexible materials, scalable manufacturing techniques now allow wearables to detect key physiological indicators such as temperature, vital signs, body motion, molecular biomarkers. With these systems operating on skin, they enable continuous noninvasive disease diagnosis health monitoring. Such complex devices, however, require suitable power sources order realize their full capacity. Emerging wearable energy harvesters are attractive for addressing challenges a supply. These convert various types ambient (e.g., biomechanical energy, biochemical solar energy) into electricity. In some circumstances, harvested electrical signals can directly be used active sensing parameters. On other hand, single or hybrid harvesters, when integrated with management circuits storage could additional well signal processing data transmission electronics. Self-powered sensor operate continuously sustainably without an external supply promising candidates next generation electronics Internet Things.This Account highlights recent progress self-powered sensors toward healthcare, covering biosensors, storage, strategies. The begins introduction our epidermal detection information. structural material innovations measure both biophysical conformably, accurately, continuously. We then discuss emerging technologies harvesting, classified according capability scavenge from sources. include examples using themselves biosensors. Through seamless integration efficient management, wireless real-time acquisition, processing, final section covers existing new opportunities monitoring human–machine interfaces precision medicine.

Язык: Английский

Процитировано

174

Soft Wearable Healthcare Materials and Devices DOI
Quanxia Lyu, Shu Gong,

Jialiang Yin

и другие.

Advanced Healthcare Materials, Год журнала: 2021, Номер 10(17)

Опубликована: Май 21, 2021

Abstract In spite of advances in electronics and internet technologies, current healthcare remains hospital‐centred. Disruptive technologies are required to translate state‐of‐art wearable devices into next‐generation patient‐centered diagnosis therapy. this review, recent the emerging field soft materials summarized. A prerequisite for such future is need novel be mechanically compliant, electrically conductive, biologically compatible. It begun with an overview two viable design strategies reported literatures, which followed by description state‐of‐the‐art monitoring physical, electrophysiological, chemical, biological signals. Self‐powered bioenergy also covered sensing systems, as well feedback‐controlled closed‐loop biodiagnostic therapy systems. Finally, it concluded overall summary perspective.

Язык: Английский

Процитировано

122

A review of IoT systems to enable independence for the elderly and disabled individuals DOI Open Access
Alfredo J. Pérez, Farhan Ahmed Siddiqui, Sherali Zeadally

и другие.

Internet of Things, Год журнала: 2022, Номер 21, С. 100653 - 100653

Опубликована: Дек. 1, 2022

Язык: Английский

Процитировано

69

The impacts of COVID-19 pandemic on service delivery and treatment outcomes in people living with HIV: a systematic review DOI Creative Commons
SeyedAhmad SeyedAlinaghi, Pegah Mirzapour, Zahra Pashaei

и другие.

AIDS Research and Therapy, Год журнала: 2023, Номер 20(1)

Опубликована: Янв. 6, 2023

Abstract Introduction The COVID-19 epidemic and various control mitigation measures to combat the widespread outbreak of disease may affect other parts health care systems. There is a concern that pandemic could disrupt HIV services. Therefore, this study aimed systematically evaluate effect on service delivery treatment outcomes in people with HIV. Methods In study, systematic search was conducted using keywords online databases including Scopus, PubMed, Web Science, Cochrane databases. retrieved articles underwent two-step title/abstract full-text review process, eligible papers were selected included qualitative synthesis. Result We 16 studies out 529 records met inclusion criteria for review. Study populations either HIV-positive patients or clinics healthcare providers. Most focused adhering obtaining medication attending clinical appointments their decrement during pandemic. Other aspects (alternative settings, viral suppression, psychological care, etc.) discussed lesser extent by studies. Conclusion Interruption in-person visits medical follow-up services, loss adherence treatment, subsequent increase mortality due complications PLHIV have led growing concerns. challenges disorders such as anxiety depression, an substance abuse, rise experienced stigma discrimination. However, use telemedicine some countries helps alleviate situation recommended similar settings future.

Язык: Английский

Процитировано

66

Challenges of Emerging Wearable Sensors for Remote Monitoring toward Telemedicine Healthcare DOI
Surachate Kalasin, Werasak Surareungchai

Analytical Chemistry, Год журнала: 2023, Номер 95(3), С. 1773 - 1784

Опубликована: Янв. 11, 2023

Digitized telemedicine tools with the Internet of Things (IoT) started advancing into our daily lives and have been incorporated commercial wearable gadgets for noninvasive remote health monitoring. The newly established steered toward a new era decentralized healthcare. advancement monitoring system has attracted enormous interest in multimodal big data acquisition real-time physiological biochemical information via methods any health-related industries. expectation creation focused on early diagnosis multiple diseases minimizing cost high-tech invasive treatments. However, only limited progress directed development sensors. This Perspective addresses these sensors that encounter challenges forefront technological gaps hampering realization at molecular levels related to smart materials mostly single use, issues selectivity analytes, low sensitivity targets, miniaturization, lack artificial intelligence perform tasks secure transfer. Sensor stability minimized signal drift, on-body sensor reusability, long-term continuous provides key analytical challenges. also focuses on, promotes, highlights distinct capability interconnect healthcare physical sensing multiplex deeper levels. Moreover, it points out some critical different material aspects promotes what will take advance current state-of-art Ultimately, this is draw attention potential blind spots technology inspire further integrated mitigating multimorbidity aging societies through identify signs diseases.

Язык: Английский

Процитировано

61