Microchimica Acta,
Год журнала:
2021,
Номер
188(4)
Опубликована: Март 10, 2021
A
voltammetric
genosensor
has
been
developed
for
the
early
diagnosis
of
COVID-19
by
determination
RNA-dependent
RNA
polymerase
(RdRP)
sequence
as
a
specific
target
novel
coronavirus.
The
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
uses
an
RdRP
replication
its
genome
and
transcription
genes.
Here,
silver
ions
(Ag+)
in
hexathia-18-crown-6
(HT18C6)
were
used
first
time
redox
probe.
Then,
HT18C6(Ag)
incorporated
carbon
paste
electrode
(CPE)
was
further
modified
with
chitosan
PAMAM
dendrimer-coated
silicon
quantum
dots
(SiQDs@PAMAM)
immobilization
probe
sequences
(aminated
oligonucleotides).
current
intensity
differential
pulse
voltammetry
using
found
to
decrease
increasing
concentration
sequence.
Based
on
such
signal-off
trend,
proposed
exhibited
good
linear
response
SARS-CoV-2
range
1.0
pM–8.0
nM
regression
equation
I
(μA)
=
−
6.555
log
[RdRP
sequence]
(pM)
+
32.676
(R2
0.995)
limit
detection
(LOD)
0.3
pM.
standard
addition
method
different
spike
concentrations
human
sputum
samples
showed
recovery
real
sample
analysis
(>
95%).
Therefore,
can
be
determine
samples.
ACS Nano,
Год журнала:
2023,
Номер
17(6), С. 5211 - 5295
Опубликована: Март 9, 2023
Humans
rely
increasingly
on
sensors
to
address
grand
challenges
and
improve
quality
of
life
in
the
era
digitalization
big
data.
For
ubiquitous
sensing,
flexible
are
developed
overcome
limitations
conventional
rigid
counterparts.
Despite
rapid
advancement
bench-side
research
over
last
decade,
market
adoption
remains
limited.
To
ease
expedite
their
deployment,
here,
we
identify
bottlenecks
hindering
maturation
propose
promising
solutions.
We
first
analyze
achieving
satisfactory
sensing
performance
for
real-world
applications
then
summarize
issues
compatible
sensor-biology
interfaces,
followed
by
brief
discussions
powering
connecting
sensor
networks.
Issues
en
route
commercialization
sustainable
growth
sector
also
analyzed,
highlighting
environmental
concerns
emphasizing
nontechnical
such
as
business,
regulatory,
ethical
considerations.
Additionally,
look
at
future
intelligent
sensors.
In
proposing
a
comprehensive
roadmap,
hope
steer
efforts
towards
common
goals
guide
coordinated
development
strategies
from
disparate
communities.
Through
collaborative
efforts,
scientific
breakthroughs
can
be
made
sooner
capitalized
betterment
humanity.
Chemical Reviews,
Год журнала:
2023,
Номер
123(8), С. 5049 - 5138
Опубликована: Март 27, 2023
Wearable
sensors
hold
great
potential
in
empowering
personalized
health
monitoring,
predictive
analytics,
and
timely
intervention
toward
healthcare.
Advances
flexible
electronics,
materials
science,
electrochemistry
have
spurred
the
development
of
wearable
sweat
that
enable
continuous
noninvasive
screening
analytes
indicative
status.
Existing
major
challenges
include:
improving
extraction
sensing
capabilities,
form
factor
device
for
minimal
discomfort
reliable
measurements
when
worn,
understanding
clinical
value
biomarker
discovery.
This
review
provides
a
comprehensive
outlines
state-of-the-art
technologies
research
strive
to
bridge
these
gaps.
The
physiology
sweat,
materials,
biosensing
mechanisms
advances,
approaches
induction
sampling
are
introduced.
Additionally,
design
considerations
system-level
devices,
spanning
from
strategies
prolonged
efficient
powering
wearables,
discussed.
Furthermore,
applications,
data
commercialization
efforts,
challenges,
prospects
precision
medicine
Journal of Personalized Medicine,
Год журнала:
2023,
Номер
13(6), С. 951 - 951
Опубликована: Июнь 5, 2023
Artificial
intelligence
(AI)
applications
have
transformed
healthcare.
This
study
is
based
on
a
general
literature
review
uncovering
the
role
of
AI
in
healthcare
and
focuses
following
key
aspects:
(i)
medical
imaging
diagnostics,
(ii)
virtual
patient
care,
(iii)
research
drug
discovery,
(iv)
engagement
compliance,
(v)
rehabilitation,
(vi)
other
administrative
applications.
The
impact
observed
detecting
clinical
conditions
diagnostic
services,
controlling
outbreak
coronavirus
disease
2019
(COVID-19)
with
early
diagnosis,
providing
care
using
AI-powered
tools,
managing
electronic
health
records,
augmenting
compliance
treatment
plan,
reducing
workload
professionals
(HCPs),
discovering
new
drugs
vaccines,
spotting
prescription
errors,
extensive
data
storage
analysis,
technology-assisted
rehabilitation.
Nevertheless,
this
science
pitch
meets
several
technical,
ethical,
social
challenges,
including
privacy,
safety,
right
to
decide
try,
costs,
information
consent,
access,
efficacy,
while
integrating
into
governance
crucial
for
safety
accountability
raising
HCPs'
belief
enhancing
acceptance
boosting
significant
consequences.
Effective
prerequisite
precisely
address
regulatory,
trust
issues
advancing
implementation
AI.
Since
COVID-19
hit
global
system,
concept
has
created
revolution
healthcare,
such
an
uprising
could
be
another
step
forward
meet
future
needs.
Advanced Materials,
Год журнала:
2021,
Номер
33(41)
Опубликована: Авг. 31, 2021
Abstract
Wearable
bioelectronics
for
continuous
and
reliable
pulse
wave
monitoring
against
body
motion
perspiration
remains
a
great
challenge
highly
desired.
Here,
low‐cost,
lightweight,
mechanically
durable
textile
triboelectric
sensor
that
can
convert
subtle
skin
deformation
caused
by
arterial
pulsatility
into
electricity
high‐fidelity
waveform
in
an
ambulatory
sweaty
setting
is
developed.
The
holds
signal‐to‐noise
ratio
of
23.3
dB,
response
time
40
ms,
sensitivity
0.21
µA
kPa
−1
.
With
the
assistance
machine
learning
algorithms,
continuously
precisely
measure
systolic
diastolic
pressure,
accuracy
validated
via
commercial
blood
pressure
cuff
at
hospital.
Additionally,
customized
cellphone
application
(APP)
based
on
built‐in
algorithm
developed
one‐click
health
data
sharing
data‐driven
cardiovascular
diagnosis.
enabled
wireless
biomonitoring
system
expected
to
offer
practical
paradigm
personalized
characterization
era
Internet
Things.
Nano-Micro Letters,
Год журнала:
2022,
Номер
14(1)
Опубликована: Июль 22, 2022
In
the
past
decade,
global
industry
and
research
attentions
on
intelligent
skin-like
electronics
have
boosted
their
applications
in
diverse
fields
including
human
healthcare,
Internet
of
Things,
human-machine
interfaces,
artificial
intelligence
soft
robotics.
Among
them,
flexible
humidity
sensors
play
a
vital
role
noncontact
measurements
relying
unique
property
rapid
response
to
change.
This
work
presents
an
overview
recent
advances
using
various
active
functional
materials
for
contactless
monitoring.
Four
categories
are
highlighted
based
resistive,
capacitive,
impedance-type
voltage-type
working
mechanisms.
Furthermore,
typical
strategies
chemical
doping,
structural
design
Joule
heating
introduced
enhance
performance
sensors.
Drawing
perception
capability,
human/plant
healthcare
management,
interactions
as
well
integrated
sensor-based
feedback
systems
presented.
The
burgeoning
innovations
this
field
will
benefit
society,
especially
during
COVID-19
epidemic,
where
cross-infection
should
be
averted
sensation
is
highly
desired.
Accounts of Materials Research,
Год журнала:
2021,
Номер
2(3), С. 184 - 197
Опубликована: Фев. 14, 2021
ConspectusWearable
biosensors
hold
the
potential
of
revolutionizing
personalized
healthcare
and
telemedicine.
Advances
in
chemical
sensing,
flexible
materials,
scalable
manufacturing
techniques
now
allow
wearables
to
detect
key
physiological
indicators
such
as
temperature,
vital
signs,
body
motion,
molecular
biomarkers.
With
these
systems
operating
on
skin,
they
enable
continuous
noninvasive
disease
diagnosis
health
monitoring.
Such
complex
devices,
however,
require
suitable
power
sources
order
realize
their
full
capacity.
Emerging
wearable
energy
harvesters
are
attractive
for
addressing
challenges
a
supply.
These
convert
various
types
ambient
(e.g.,
biomechanical
energy,
biochemical
solar
energy)
into
electricity.
In
some
circumstances,
harvested
electrical
signals
can
directly
be
used
active
sensing
parameters.
On
other
hand,
single
or
hybrid
harvesters,
when
integrated
with
management
circuits
storage
could
additional
well
signal
processing
data
transmission
electronics.
Self-powered
sensor
operate
continuously
sustainably
without
an
external
supply
promising
candidates
next
generation
electronics
Internet
Things.This
Account
highlights
recent
progress
self-powered
sensors
toward
healthcare,
covering
biosensors,
storage,
strategies.
The
begins
introduction
our
epidermal
detection
information.
structural
material
innovations
measure
both
biophysical
conformably,
accurately,
continuously.
We
then
discuss
emerging
technologies
harvesting,
classified
according
capability
scavenge
from
sources.
include
examples
using
themselves
biosensors.
Through
seamless
integration
efficient
management,
wireless
real-time
acquisition,
processing,
final
section
covers
existing
new
opportunities
monitoring
human–machine
interfaces
precision
medicine.
Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(17)
Опубликована: Май 21, 2021
Abstract
In
spite
of
advances
in
electronics
and
internet
technologies,
current
healthcare
remains
hospital‐centred.
Disruptive
technologies
are
required
to
translate
state‐of‐art
wearable
devices
into
next‐generation
patient‐centered
diagnosis
therapy.
this
review,
recent
the
emerging
field
soft
materials
summarized.
A
prerequisite
for
such
future
is
need
novel
be
mechanically
compliant,
electrically
conductive,
biologically
compatible.
It
begun
with
an
overview
two
viable
design
strategies
reported
literatures,
which
followed
by
description
state‐of‐the‐art
monitoring
physical,
electrophysiological,
chemical,
biological
signals.
Self‐powered
bioenergy
also
covered
sensing
systems,
as
well
feedback‐controlled
closed‐loop
biodiagnostic
therapy
systems.
Finally,
it
concluded
overall
summary
perspective.
AIDS Research and Therapy,
Год журнала:
2023,
Номер
20(1)
Опубликована: Янв. 6, 2023
Abstract
Introduction
The
COVID-19
epidemic
and
various
control
mitigation
measures
to
combat
the
widespread
outbreak
of
disease
may
affect
other
parts
health
care
systems.
There
is
a
concern
that
pandemic
could
disrupt
HIV
services.
Therefore,
this
study
aimed
systematically
evaluate
effect
on
service
delivery
treatment
outcomes
in
people
with
HIV.
Methods
In
study,
systematic
search
was
conducted
using
keywords
online
databases
including
Scopus,
PubMed,
Web
Science,
Cochrane
databases.
retrieved
articles
underwent
two-step
title/abstract
full-text
review
process,
eligible
papers
were
selected
included
qualitative
synthesis.
Result
We
16
studies
out
529
records
met
inclusion
criteria
for
review.
Study
populations
either
HIV-positive
patients
or
clinics
healthcare
providers.
Most
focused
adhering
obtaining
medication
attending
clinical
appointments
their
decrement
during
pandemic.
Other
aspects
(alternative
settings,
viral
suppression,
psychological
care,
etc.)
discussed
lesser
extent
by
studies.
Conclusion
Interruption
in-person
visits
medical
follow-up
services,
loss
adherence
treatment,
subsequent
increase
mortality
due
complications
PLHIV
have
led
growing
concerns.
challenges
disorders
such
as
anxiety
depression,
an
substance
abuse,
rise
experienced
stigma
discrimination.
However,
use
telemedicine
some
countries
helps
alleviate
situation
recommended
similar
settings
future.
Analytical Chemistry,
Год журнала:
2023,
Номер
95(3), С. 1773 - 1784
Опубликована: Янв. 11, 2023
Digitized
telemedicine
tools
with
the
Internet
of
Things
(IoT)
started
advancing
into
our
daily
lives
and
have
been
incorporated
commercial
wearable
gadgets
for
noninvasive
remote
health
monitoring.
The
newly
established
steered
toward
a
new
era
decentralized
healthcare.
advancement
monitoring
system
has
attracted
enormous
interest
in
multimodal
big
data
acquisition
real-time
physiological
biochemical
information
via
methods
any
health-related
industries.
expectation
creation
focused
on
early
diagnosis
multiple
diseases
minimizing
cost
high-tech
invasive
treatments.
However,
only
limited
progress
directed
development
sensors.
This
Perspective
addresses
these
sensors
that
encounter
challenges
forefront
technological
gaps
hampering
realization
at
molecular
levels
related
to
smart
materials
mostly
single
use,
issues
selectivity
analytes,
low
sensitivity
targets,
miniaturization,
lack
artificial
intelligence
perform
tasks
secure
transfer.
Sensor
stability
minimized
signal
drift,
on-body
sensor
reusability,
long-term
continuous
provides
key
analytical
challenges.
also
focuses
on,
promotes,
highlights
distinct
capability
interconnect
healthcare
physical
sensing
multiplex
deeper
levels.
Moreover,
it
points
out
some
critical
different
material
aspects
promotes
what
will
take
advance
current
state-of-art
Ultimately,
this
is
draw
attention
potential
blind
spots
technology
inspire
further
integrated
mitigating
multimorbidity
aging
societies
through
identify
signs
diseases.