Barriers and facilitators to anti-retroviral therapy adherence among adolescents aged 10 to 19 years living with HIV in sub-Saharan Africa: A mixed-methods systematic review and meta-analysis

PLoS ONE, Год журнала: 2023, Номер 18(5), С. e0276411 - e0276411

Опубликована: Май 18, 2023

Background Human Immunodeficiency Virus (HIV) significantly affects adolescents globally, with the sub-Saharan Africa (SSA) reporting a high burden of disease. HIV testing, treatment, and retention to care are low among adolescents. We conducted mixed-method systematic review assess anti-retroviral therapy (ART) adherence; barriers facilitators ART adherence outcomes living on in Africa. Methods searches four scientific databases for studies between 2010 March 2022 identify relevant primary studies. Studies were screened against inclusion criteria assessed quality, data was extracted. Meta-analysis rates odd ratios used plot quantitative meta-synthesis summarized evidence from qualitative Results A total 10 431 identified inclusion/ exclusion criteria. Sixty-six met (41 quantitative, 16 qualitative, 9 mixed-methods study designs). Fifty-three thousand two hundred seventeen (53 217) (52 319 899 studies) included review. Thirteen support focused interventions improved The plotted results meta-analysis found an rate 65% (95%CI 56–74), viral load suppression 55% 46–64), un-suppressed 41% 32–50), loss follow up 17% 10–24) Meta-synthesis six themes (social, patient-based, economic, health system-based, therapy-based, cultural barriers) both studies, three also (social support, counselling, education secrecy or confidentiality) Conclusion remains SSA despite multiple implemented improve adherence. may hinder attainment UNAIDS 2030 targets. Additionally, various due lack have been reported this age group. However, aimed at improving social educating, counselling sustain Trial registration Systematic registration: PROSPERO CRD42021284891 .

Язык: Английский

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The role of HLA genetic variants in COVID‐19 susceptibility, severity, and mortality: A global review

Journal of Clinical Laboratory Analysis, Год журнала: 2024, Номер 38(1-2)

Опубликована: Янв. 1, 2024

Abstract Background The COVID‐19 pandemic has had a profound global impact, with variations in susceptibility, severity, and mortality rates across different regions. While many factors can contribute to the spread impact of disease, specifically human leukocyte antigen (HLA) genetic variants have emerged as potential contributors outcomes. Methods In this comprehensive narrative review, we conducted thorough literature search identify relevant studies investigating association between HLA Additionally, analyzed allelic frequency data from diverse populations assess differences incidence severity. Results Our review provides insights into immunological mechanisms involving HLA‐mediated responses highlights research directions therapeutic interventions. We found evidence suggesting that certain alleles, such HLA‐A02, may confer lower risk COVID‐19, while others, like HLA‐C04, increase severe symptoms mortality. Furthermore, our analysis allele distributions revealed significant among populations. Conclusion Considering host variations, particularly variants, is crucial for understanding susceptibility These findings implications personalized treatment interventions based on an individual's profile. However, further needed unravel precise underlying observed associations explore targeted therapies or preventive measures variants.

Язык: Английский

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Stigma and mental health among people living with HIV across the COVID-19 pandemic: a cross-sectional study

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Апрель 22, 2024

Abstract Background Mental health (MH) is extremely relevant when referring to people living with a chronic disease, such as HIV (PLWH). In fact – although life expectancy and quality have increased since the advent of antiretroviral therapy (ART) PLWH carry high incidence mental disorders, this burden has been exacerbated during COVID-19 pandemic. scenario, UNAIDS set new objectives for 2025, linkage at least 90% people-centered, context-specific MH services. Aim study was determine prevalence MD in followed Clinic Infectious Diseases University Bari, Italy. Methods From January 10th September 10th, 2022, all patients accessing our outpatient clinic were offered following standardized tools: HAM-A anxiety, BDI-II depression, PC-PTSD-5 post-traumatic stress disorder, CAGE-AID alcohol-drug abuse. Factors associated testing positive four explored multivariable logistic regression model. Results 578 out 1110 HIV-patients agreed receive screening, 141 (24.4%) resulting one disorder. 15.8% ( n = 91), 18% 104), 5% 29) CAGE 6.1% 35). The showed higher probability being diagnosed depression disorder who reported severe stigma, social isolation, psychological deterioration pandemic those receiving dolutegravir (DTG)-based regimen. Moreover, history drug use (OR 1.13; [95% CE 1.06–4.35]), family stigma (2.42 [1.65–3.94]) isolation (2.72 [1.55;4.84]) found be risk substance Conclusions study, strong predictor among PLWH. Also, possible role factor onset disorders should considered clinical practice, DTG-containing regimens constantly monitored.

Язык: Английский

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Does telehealth affect the adherence to ART among patients with HIV? A systematic review and meta-analysis

BMC Infectious Diseases, Год журнала: 2023, Номер 23(1)

Опубликована: Март 17, 2023

Several studies have shown different effects of telehealth interventions on adherence to Antiretroviral therapy (ART) among people living with HIV. This study conducted a meta-analysis Randomized Controlled Trials (RCTs) estimate the pooled effect treatment HIV patients.The researchers literature searches in Scopus, PubMed, Web Science, Google Scholar, and Cochrane Central Register databases. In addition, open grey was systematically searched until January 2022 for RCTs around ART patients Each study's methodological quality assessed using Collaboration tool. Pooled Standard Mean Differences (SMD) Risk Ratio (RR) 95% CI were calculated random model.In total, 12 eligible articles considered present systematic review. A random-effects 5 yielded RR 1.18 (95% CI: 1.03 1.35, p < 0.05); I2 = 0, suggesting who received intervention significantly 18% upper than control groups. Moreover, analysis SMD showed positive SMR 0.36 0.22 0.49, 91.9%, indicating that increased group compared group.Telehealth as new modality health care service delivery could be valuable strategy improve It can strengthen capacity services. On large scale, utilized supplementary component retention toward successful therapy.

Язык: Английский

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The impact of COVID-19 on HIV care: a comprehensive analysis of patient and healthcare providers experiences at the largest HIV treatment center in Ghana

BMC Health Services Research, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 6, 2025

We sought to determine how the COVID-19 pandemic affected care delivery for HIV patients in Ghana. Guided by Consolidated Framework Implementation Research (CFIR), we performed a cross-sectional study between May and July 2021 among 40 people living with 19 healthcare providers caring patients. In-depth interviews focus group discussions were done patients, doctors, nurses, pharmacists, laboratory scientists, data administrators, counselors ascertain barriers facilitators during pandemic. asked their input on removing this future pandemics. Data was analyzed thematically help of qualitative software MAXQDA. Pre-pandemic practices, such as using cards appointments making phone calls intra-pandemic measures, re-arranging clinic setup patient safety, contributed attendance. However, fear infection, transportation costs, stigma impeded Patients spent less time because stable received medication refills without seeing doctor. This meant many chronic diseases like hypertension, diabetes, hyperlipidemia did not get necessary physician review pandemic's peak. Due pervasive stigma, cautious about home medications telemedicine solutions. While solutions visits may work primary or other conditions pandemics, makes these interventions unattractive options

Язык: Английский

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Impact of COVID-19 on Utilization of Healthcare Services Among People Living with HIV (PLHIV): A Systematic Review

Medicina, Год журнала: 2025, Номер 61(1), С. 111 - 111

Опубликована: Янв. 14, 2025

Background and Objectives: People living with HIV/AIDS have been impacted notably by the COVID-19 pandemic in diverse dimensions. Although some impacts of on PLHIV well documented, there is still insufficient research that captures overall understanding implications for healthcare utilization among PLHIV. This review aims to evaluate impact PLHIV, narrowing it down women HIV/AIDS. Materials Methods: An electronic database search primary studies obtained information from health facility data regarding since 2020 was carried out according PRISMA statement. A combination terms, e.g., “COVID-19 pandemic”, “SARS-CoV-2”, “Health services utilization”, “People Human immunodeficiency virus”, included. Results: There an decline such as medical consultations, ART uptake, viral load monitoring at centers forefront care delivery. However, countries sub-Saharan African region showed a progressive service increase over pandemic. scarcity populations Other methods delivery telemedicine postage were instrumental HIV services. Conclusions: The reduced uptake need boost strengthen emergency preparedness particularly HIV/AIDS, during pandemics further harness maximize use contemporary other than traditional ones.

Язык: Английский

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Impact of the COVID-19 pandemic lockdown in women living with HIV who have a Black African and/or Black Caribbean heritage

HIV Research & Clinical Practice, Год журнала: 2025, Номер 26(1)

Опубликована: Фев. 13, 2025

Objective Treatment, adherence and linkage to care are lower in Black African Caribbean heritage women living with HIV, affected by significant psychosocial challenges compared other groups. The COVID-19 lockdowns further amplified these inequalities. We aimed assess its impact on this population across Chelsea Westminster Hospitals NHS Foundation Trust.

Язык: Английский

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COVID-19 Pandemic’s Impact on HIV and AIDS Case Reporting in Peru: A Time Series Analysis of Surveillance Data (1983–2023)

AIDS and Behavior, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

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Impacts of the COVID-19 Pandemic on the HIV Care Continuum and Associated Factors in High-Income Nations: A Mixed-Methods Systematic Review

AIDS and Behavior, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

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Hardships and Perceived Barriers to Medical Care Among Newly Diagnosed People With HIV During the COVID-19 Pandemic

Journal of the International Association of Providers of AIDS Care (JIAPAC), Год журнала: 2025, Номер 24

Опубликована: Март 1, 2025

Purpose of the researchA major consequence COVID-19 pandemic was a disruption medical care in United States. Using cross-sectional data from an ongoing randomized clinical trial, we examined severity COVID-related hardships and other factors that might have influenced newly diagnosed people with HIV's (PWH's) receipt during initial years (2020-22).Major findingsIn sample 29 PWH presenting for at three geographically diverse clinics States, results showed most patients (72.4%) reported obtaining HIV appointment "easy." Correlational analyses found were significantly related to overall health functioning, as well experiences discrimination.ConclusionsTaken together, these findings align previous show already vulnerable populations particularly affected by service disruptions, but many able access despite pandemic.

Язык: Английский

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