Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 216006 - 216006
Опубликована: Июнь 18, 2024
Язык: Английский
Chemical Society Reviews, Год журнала: 2023, Номер 52(12), С. 3955 - 3972
Опубликована: Янв. 1, 2023
This review highlights recent advances in the utilization of various endogenous and exogenous stimuli to activate nanocarrier-based ferroptosis cancer therapy that can be effective treating conventional drug-resistant tumors.
Язык: Английский
Процитировано
136
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(40)
Опубликована: Авг. 17, 2023
Abstract Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment. Herein, simple drug‐free inorganic nanomaterial, alkalescent sodium bicarbonate nanoparticles (NaHCO 3 NPs), prepared via fast microemulsion method for amplified cancer immunotherapy. The obtained NaHCO regulates lactic acid metabolism through acid‐base neutralization so as to reverse the mildly acidic environment. Additionally, can further release high amounts of Na + ions inside cells induce surge in intracellular osmolarity, thus activate pyroptosis pathway immunogenic cell death (ICD), damage‐associated molecular patterns (DAMPs) inflammatory factors, improve responses. Collectively, NPs observably inhibit primary/distal growth metastasis remitted immunosuppression induced activation, showing an enhanced antitumor immunity efficiency. This work provides new paradigm mediated treatment, which potential
Язык: Английский
Процитировано
64
Advanced Functional Materials, Год журнала: 2023, Номер 33(38)
Опубликована: Июнь 6, 2023
Abstract Copper overload is a novel way to achieve copper‐ion‐interference therapy by disrupting copper homeostasis and treating diseases through multiple cell death pathways. However, it difficult reach since excess intracellular ions will be pumped out. Herein, achieved both raising cellular uptake reducing the efflux of using hydrogen sulfide (H 2 S)‐responsive hydroxyphosphate nanoparticles (Cu (PO 4 )(OH) NPs). After immersion in an H S‐enriched colon cancer microenvironment, Cu NPs can transform into with reduced size for higher entering, resulting improved Fenton activity as well ion dissociation. Reactive oxygen species generated reaction not only activate inflammasomes Caspase‐1 proteins, cause cleavage gasdermin D induce pyroptosis, but also affect mitochondrial function down‐regulate exporter ATP7A further reduce excretion. The combination endocytosis lower exportation leads maximized overload. Together efficient release, tricarboxylic acid cycle disrupted iron‐sulfur cluster proteins are downregulated, ultimately triggering cuproptosis. As pyroptosis cuproptosis ways death, this study provides realize effective tumor‐targeted based on S‐activated simple NPs.
Язык: Английский
Процитировано
53
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 237, С. 113871 - 113871
Опубликована: Март 21, 2024
Язык: Английский
Процитировано
38
Exploration, Год журнала: 2024, Номер 4(6)
Опубликована: Март 22, 2024
Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.
Язык: Английский
Процитировано
31
Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(9)
Опубликована: Янв. 9, 2024
Designing reactive calcium-based nanogenerators to produce excess calcium ions (Ca
Язык: Английский
Процитировано
25
Biomaterials, Год журнала: 2025, Номер 317, С. 123111 - 123111
Опубликована: Янв. 15, 2025
Язык: Английский
Процитировано
3
Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)
Опубликована: Окт. 23, 2022
Abstract Due to the urgent demand for more anti-cancer methods, new applications of metal ions in cancer have attracted increasing attention. Especially three kinds mode cell death, including ferroptosis, calcicoptosis, and cuproptosis, are great concern. Meanwhile, many been found induce death through different approaches, such as interfering with osmotic pressure, triggering biocatalysis, activating immune pathways, generating prooxidant effect. Therefore, varieties strategies based on above approaches studied applied applications. Moreover, contrast agents gradually become core components bioimaging technologies, MRI, CT, fluorescence imaging, which exhibit guiding significance diagnosis. Besides, nano-theranostic platforms experimentally shown efficient response endogenous exogenous stimuli, realizes simultaneous therapy diagnosis a controlled nano-system. However, most metal-based still early stages, clinical trials necessary confirm or not current expectations. This article will focus these explorations ions, hoping provide some theoretical support ideas.
Язык: Английский
Процитировано
69
Advanced Science, Год журнала: 2022, Номер 9(35)
Опубликована: Окт. 20, 2022
The terrible morbidity and mortality of malignant tumors urgently require innovative therapeutics, especially for apoptosis-resistant tumors. Pyroptosis, a pro-inflammatory form programmed cell death (PCD), is featured with pore formation in plasma membrane, swelling giant bubbles, leakage cytoplasmic cytokines, which can remodel the tumor immune microenvironment by stimulating "cold" to be an immunogenic "hot" microenvironment, consequently augment therapeutic efficiency Benefiting from current advances nanotechnology, nanomedicine extensively applied potentiate, enable, pyroptosis enhancing cancer-therapeutic efficacy specificity. This review provides concentrated summary discussion most recent progress achieved this emerging field, highlighting nanomedicine-enabled/augmented specific strategy favoring construction next-generation nanomedicines efficiently induce PCD. It highly expected that further clinical translation accelerated inducing pyroptotic based on bioactive nanomedicines.
Язык: Английский
Процитировано
60
Advanced Functional Materials, Год журнала: 2022, Номер 33(3)
Опубликована: Ноя. 14, 2022
Abstract Calcium ion is vital for the regulation of many cellular functions and serves as a second messenger in signal transduction pathways. Once intracellular Ca 2+ level exceeds tolerance cells (called overload), oxidative stress, mitochondrial damage, cell/mitochondria apoptosis happen. Therefore, overload has started to be deeply exploited new strategy cancer therapy due its high efficiency satisfactory safety. This review aims highlight recent development ‐based nanomaterials (such 3 (PO 4 ) 2 , CaCO CaO CaH CaS, others) able trigger therapy. The mechanisms varied different types strategies enhance are discussed detail. Moreover, design more efficient overload‐mediated therapies prospected mainly based on 1) enhanced uptake by surface modification morphology optimization nanomaterials, 2) accelerated release from increasing H + photothermal effect, 3) maintenance efflux inhibition, influx promotion, or promoting endoplasmic reticulum.
Язык: Английский
Процитировано
57