Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(19)
Published: March 14, 2023
Abstract
Pd‐catalyzed
chemistry
has
played
a
significant
role
in
the
growing
subfield
of
bioorthogonal
catalysis.
However,
rationally
designing
Pd
nanocatalysts
that
show
outstanding
catalytic
activity
and
good
biocompatibility
poses
great
challenge.
Herein,
we
propose
an
innovative
strategy
through
exploiting
black
phosphorous
nanosheets
(BPNSs)
to
enhance
Pd‐mediated
activity.
Firstly,
electron‐donor
properties
BPNSs
enable
situ
growth
nanoparticles
(PdNPs)
on
it.
Meanwhile,
due
superb
capability
reducing
II
,
can
act
as
hard
nucleophiles
accelerate
transmetallation
decaging
reaction
process.
Secondly,
lone
pair
electrons
firmly
anchor
PdNPs
their
surface
via
Pd−P
bonds.
This
design
endows
Pd/BP
with
retard
tumor
by
activating
prodrugs.
work
proposes
new
insights
into
heterogeneous
transition‐metal
catalysts
(TMCs)
for
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(12), P. 3955 - 3972
Published: Jan. 1, 2023
This
review
highlights
recent
advances
in
the
utilization
of
various
endogenous
and
exogenous
stimuli
to
activate
nanocarrier-based
ferroptosis
cancer
therapy
that
can
be
effective
treating
conventional
drug-resistant
tumors.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(40)
Published: Aug. 17, 2023
Abstract
Although
immunotherapy
has
a
broad
clinical
application
prospect,
it
is
still
hindered
by
low
immune
responses
and
immunosuppressive
tumor
microenvironment.
Herein,
simple
drug‐free
inorganic
nanomaterial,
alkalescent
sodium
bicarbonate
nanoparticles
(NaHCO
3
NPs),
prepared
via
fast
microemulsion
method
for
amplified
cancer
immunotherapy.
The
obtained
NaHCO
regulates
lactic
acid
metabolism
through
acid‐base
neutralization
so
as
to
reverse
the
mildly
acidic
environment.
Additionally,
can
further
release
high
amounts
of
Na
+
ions
inside
cells
induce
surge
in
intracellular
osmolarity,
thus
activate
pyroptosis
pathway
immunogenic
cell
death
(ICD),
damage‐associated
molecular
patterns
(DAMPs)
inflammatory
factors,
improve
responses.
Collectively,
NPs
observably
inhibit
primary/distal
growth
metastasis
remitted
immunosuppression
induced
activation,
showing
an
enhanced
antitumor
immunity
efficiency.
This
work
provides
new
paradigm
mediated
treatment,
which
potential
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(38)
Published: June 6, 2023
Abstract
Copper
overload
is
a
novel
way
to
achieve
copper‐ion‐interference
therapy
by
disrupting
copper
homeostasis
and
treating
diseases
through
multiple
cell
death
pathways.
However,
it
difficult
reach
since
excess
intracellular
ions
will
be
pumped
out.
Herein,
achieved
both
raising
cellular
uptake
reducing
the
efflux
of
using
hydrogen
sulfide
(H
2
S)‐responsive
hydroxyphosphate
nanoparticles
(Cu
(PO
4
)(OH)
NPs).
After
immersion
in
an
H
S‐enriched
colon
cancer
microenvironment,
Cu
NPs
can
transform
into
with
reduced
size
for
higher
entering,
resulting
improved
Fenton
activity
as
well
ion
dissociation.
Reactive
oxygen
species
generated
reaction
not
only
activate
inflammasomes
Caspase‐1
proteins,
cause
cleavage
gasdermin
D
induce
pyroptosis,
but
also
affect
mitochondrial
function
down‐regulate
exporter
ATP7A
further
reduce
excretion.
The
combination
endocytosis
lower
exportation
leads
maximized
overload.
Together
efficient
release,
tricarboxylic
acid
cycle
disrupted
iron‐sulfur
cluster
proteins
are
downregulated,
ultimately
triggering
cuproptosis.
As
pyroptosis
cuproptosis
ways
death,
this
study
provides
realize
effective
tumor‐targeted
based
on
S‐activated
simple
NPs.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 22, 2024
Abstract
Metals
are
an
emerging
topic
in
cancer
immunotherapy
that
have
shown
great
potential
modulating
immunity
cycle
and
promoting
antitumor
by
activating
the
intrinsic
immunostimulatory
mechanisms
which
been
identified
recent
years.
The
main
challenge
of
metal‐assisted
lies
fact
free
metals
as
ion
forms
easily
cleared
during
circulation,
even
cause
systemic
metal
toxicity
due
to
off‐target
effects.
With
rapid
development
nanomedicine,
metal‐based
smart
nanosystems
(MSNs)
with
unique
controllable
structure
become
one
most
promising
delivery
carriers
solve
issue,
owing
their
various
endogenous/external
stimuli‐responsiveness
release
ions
for
metalloimmunotherapy.
In
this
review,
state‐of‐the‐art
research
progress
metal‐related
is
comprehensively
summarized.
First,
mainstream
MSNs‐assisted
will
be
delineated.
immunological
effects
certain
categorization
MSNs
different
characters
compositions
then
provided,
followed
representative
exemplar
applications
treatment,
synergistic
combination
immunotherapy.
Finally,
we
conclude
review
a
summary
remaining
challenges
associated
provide
authors'
perspective
on
further
advances.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Oct. 23, 2022
Abstract
Due
to
the
urgent
demand
for
more
anti-cancer
methods,
new
applications
of
metal
ions
in
cancer
have
attracted
increasing
attention.
Especially
three
kinds
mode
cell
death,
including
ferroptosis,
calcicoptosis,
and
cuproptosis,
are
great
concern.
Meanwhile,
many
been
found
induce
death
through
different
approaches,
such
as
interfering
with
osmotic
pressure,
triggering
biocatalysis,
activating
immune
pathways,
generating
prooxidant
effect.
Therefore,
varieties
strategies
based
on
above
approaches
studied
applied
applications.
Moreover,
contrast
agents
gradually
become
core
components
bioimaging
technologies,
MRI,
CT,
fluorescence
imaging,
which
exhibit
guiding
significance
diagnosis.
Besides,
nano-theranostic
platforms
experimentally
shown
efficient
response
endogenous
exogenous
stimuli,
realizes
simultaneous
therapy
diagnosis
a
controlled
nano-system.
However,
most
metal-based
still
early
stages,
clinical
trials
necessary
confirm
or
not
current
expectations.
This
article
will
focus
these
explorations
ions,
hoping
provide
some
theoretical
support
ideas.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(35)
Published: Oct. 20, 2022
The
terrible
morbidity
and
mortality
of
malignant
tumors
urgently
require
innovative
therapeutics,
especially
for
apoptosis-resistant
tumors.
Pyroptosis,
a
pro-inflammatory
form
programmed
cell
death
(PCD),
is
featured
with
pore
formation
in
plasma
membrane,
swelling
giant
bubbles,
leakage
cytoplasmic
cytokines,
which
can
remodel
the
tumor
immune
microenvironment
by
stimulating
"cold"
to
be
an
immunogenic
"hot"
microenvironment,
consequently
augment
therapeutic
efficiency
Benefiting
from
current
advances
nanotechnology,
nanomedicine
extensively
applied
potentiate,
enable,
pyroptosis
enhancing
cancer-therapeutic
efficacy
specificity.
This
review
provides
concentrated
summary
discussion
most
recent
progress
achieved
this
emerging
field,
highlighting
nanomedicine-enabled/augmented
specific
strategy
favoring
construction
next-generation
nanomedicines
efficiently
induce
PCD.
It
highly
expected
that
further
clinical
translation
accelerated
inducing
pyroptotic
based
on
bioactive
nanomedicines.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(3)
Published: Nov. 14, 2022
Abstract
Calcium
ion
is
vital
for
the
regulation
of
many
cellular
functions
and
serves
as
a
second
messenger
in
signal
transduction
pathways.
Once
intracellular
Ca
2+
level
exceeds
tolerance
cells
(called
overload),
oxidative
stress,
mitochondrial
damage,
cell/mitochondria
apoptosis
happen.
Therefore,
overload
has
started
to
be
deeply
exploited
new
strategy
cancer
therapy
due
its
high
efficiency
satisfactory
safety.
This
review
aims
highlight
recent
development
‐based
nanomaterials
(such
3
(PO
4
)
2
,
CaCO
CaO
CaH
CaS,
others)
able
trigger
therapy.
The
mechanisms
varied
different
types
strategies
enhance
are
discussed
detail.
Moreover,
design
more
efficient
overload‐mediated
therapies
prospected
mainly
based
on
1)
enhanced
uptake
by
surface
modification
morphology
optimization
nanomaterials,
2)
accelerated
release
from
increasing
H
+
photothermal
effect,
3)
maintenance
efflux
inhibition,
influx
promotion,
or
promoting
endoplasmic
reticulum.
