Aggregation-Induced Emission (AIE), Life and Health

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405

Опубликована: Июль 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Язык: Английский

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Scarless wound healing programmed by core-shell microneedles

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июнь 10, 2023

Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well inappropriate dosing timing in distinct stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed dynamically modulate immune microenvironment according varied phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, ROS-sensitive MN shell gradually degrades expose core component, which neutralizes various inflammatory factors and promotes phase transition from inflammation proliferation. In addition, released verteporfin inhibits scar formation blocking Engrailed-1 (En1) activation fibroblasts. Our experiments demonstrate that promote scarless repair mouse models both acute wounds, inhibit hypertrophic rabbit ear models.

Язык: Английский

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Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Июль 26, 2022

Abstract Cancer remains a serious threat to human health owing the lack of effective treatments. Photodynamic therapy (PDT) has emerged as promising non-invasive cancer treatment that consists three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone aggregation-caused quenching (ACQ), leading reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due their distorted structure, suppress strong molecular interactions, making them more photosensitive in aggregated state instead. Activated by light, they can efficiently produce ROS induce cell death. PS is one core factors efficient PDT, so proceeding from design preparation AIE-PSs, including how manipulate electron donor (D) receptor (A) configuration, introduce heavy atoms or metal complexes, Type I polymerization-enhanced photosensitization nano-engineering approaches. Then, preclinical experiments AIE-PSs treating different types tumors, such ovarian cancer, cervical lung breast its great potential clinical applications discussed. In addition, perspectives on further development presented. This review hopes stimulate interest researchers fields chemistry, materials science, biology, medicine, promote translation AIE-PSs. Graphical

Язык: Английский

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An AIE Photosensitizer with Simultaneous Type I and Type II ROS Generation: Efficient Bacterial Elimination and Hypoxic Tumor Ablation

Advanced Functional Materials, Год журнала: 2023, Номер 33(33)

Опубликована: Апрель 25, 2023

Abstract Aggregation induced emission (AIE) photosensitizers have attracted great attention due to their good performance in photodynamic therapy (PDT). However, the therapeutic effect of AIE photosensitizer is often highly dependent on biological microenvironment because it difficult produce type I and II reactive oxygen species (ROS) simultaneously. Herein, an electron‐rich anion‐ π + AIEgen Pys‐QM‐TT reported, which capable generating ROS realizing near‐infrared fluorescence imaging synchronously. In rational design photosensitizer, strong electron‐donating triphenylamine unit, π‐bridge thiophene electron‐withdrawing pyridinium salt unit can enhance D–π–A behavior, thereby improving intramolecular charge transfer extending wavelength. Meanwhile, powerful supposed reduce ∆ E S‐T promote intersystem crossing processes, thus increasing generation ROS. addition, negatively charged anion group provides environment for excited so as electron generate Therefore, not only simultaneously with weak environmental dependence, but also effectively inhibit bacterial infections ablate tumor tissue by promoting cell apoptosis, inhibiting proliferation anti‐angiogenesis.

Язык: Английский

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Achieving Clearance of Drug‐Resistant Bacterial Infection and Rapid Cutaneous Wound Regeneration Using an ROS‐Balancing‐Engineered Heterojunction

Advanced Materials, Год журнала: 2024, Номер 36(16)

Опубликована: Фев. 1, 2024

Abstract Intractable infected microenvironments caused by drug‐resistant bacteria stalls the normal course of wound healing. Sono‐piezodynamic therapy (SPT) is harnessed to combat pathogenic bacteria, but superabundant reactive oxygen species (ROS) generated during SPT inevitably provoke severe inflammatory response, hindering tissue regeneration. Consequently, an intelligent nanocatalytic membrane composed poly(lactic‐co‐glycolic acid) (PLGA) and black phosphorus /V 2 C MXene bio‐heterojunctions (2D ‐bioHJs) devised. Under ultrasonication, 2D ‐bioHJs effectively eliminate disrupting metabolism electron transport chain (ETC). When ultrasonication ceases, they enable elimination SPT‐generated ROS. The act as a “lever” that achieves balance between ROS generation annihilation, delivering both antibacterial anti‐inflammatory properties engineered membrane. More importantly, in vivo assays corroborate membranes transform stalled chronic environment into regenerative one eradicating bacterial population, dampening NF‐κB pathway promoting angiogenesis. As envisaged, this work demonstrates novel tactic arm with programmed effects remedy refractory wounds from drug‐fast bacteria.

Язык: Английский

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Recent advances in type I organic photosensitizers for efficient photodynamic therapy for overcoming tumor hypoxia

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(21), С. 4600 - 4618

Опубликована: Янв. 1, 2023

Photodynamic therapy (PDT) with an oxygen-dependent character is a noninvasive therapeutic method for cancer treatment.

Язык: Английский

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Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives

Acta Biomaterialia, Год журнала: 2024, Номер 177, С. 1 - 19

Опубликована: Фев. 7, 2024

Язык: Английский

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One-Stop Integrated Nanoagent for Bacterial Biofilm Eradication and Wound Disinfection

ACS Nano, Год журнала: 2024, Номер 18(5), С. 4089 - 4103

Опубликована: Янв. 25, 2024

To meet the requirements of biomedical applications in antibacterial realm, it is great importance to explore nano-antibiotics for wound disinfection that can prevent development drug resistance and possess outstanding biocompatibility. Therefore, we attempted synthesize an atomically dispersed ion (Fe) on phenolic carbon quantum dots (CQDs) combined with organic photothermal agent (PTA) (Fe@SAC CQDs/PTA) via a hydrothermal/ultrasound method. Fe@SAC CQDs adequately exerted peroxidase-like activity while PTA presented excellent conversion capability, which provided enormous potential applications. Based our work, CQDs/PTA exhibited eradication Escherichia coli (>99% inactivation efficiency) Staphylococcus aureus based synergistic chemodynamic therapy (CDT) (PTT). Moreover, vitro experiments demonstrated could inhibit microbial growth promote bacterial biofilm destruction. In vivo suggested CQDs/PTA-mediated CDT PTT promotion recovery effects. This work indicated serve as broad-spectrum antimicrobial nano-antibiotic, was simultaneously beneficial eradication, disinfection, healing.

Язык: Английский

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Supramolecular H-Aggregates of Squaraines with Enhanced Type I Photosensitization for Combined Photodynamic and Photothermal Therapy

ACS Nano, Год журнала: 2024, Номер 18(37), С. 25671 - 25684

Опубликована: Сен. 3, 2024

Combined photodynamic and photothermal therapy (PDT PTT) can achieve more superior therapeutic effects than the sole mode by maximizing photon utilization, but there remains a significant challenge in development of related single-molecule photosensitizers (PSs), particularly those with type I photosensitization. In this study, self-assembly squaraine dyes (SQs) is shown to be promising strategy for designing PSs combined PDT PTT, supramolecular PS (TPE-SQ7) has been successfully developed through subtle molecular design an indolenine SQ, which self-assemble into highly ordered H-aggregates aqueous solution as well nanoparticles (NPs). contrast typical quenching effect on reactive oxygen species (ROS) generation, our results encouragingly manifest that enhance ROS (

Язык: Английский

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Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 10, 2024

Abstract The development of Type I photosensitizers (PSs) is great importance due to the inherent hypoxic intolerance photodynamic therapy (PDT) in microenvironment. Compared II PSs, PSs are less reported absence a general molecular design strategy. Herein, we report that combination typical PS and natural substrate carvacrol (CA) can significantly facilitate pathway efficiently generate superoxide radical (O 2 –• ). Detailed mechanism study suggests CA activated into thymoquinone (TQ) by local singlet oxygen generated from upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes conversion O via transfer-based pathway. Notably, three classical employed demonstrate universality proposed approach. PDT against S. aureus has been demonstrated under conditions vitro. Furthermore, this coupled agent exhibits significant bactericidal activity with antibacterial rate 99.6% for bacterial-infection female mice vivo experiments. Here, show simple, effective, universal method endow traditional tolerance.

Язык: Английский

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