ACS Applied Bio Materials,
Год журнала:
2023,
Номер
7(1), С. 44 - 58
Опубликована: Дек. 18, 2023
Epithelial-mesenchymal
transition
(EMT)
is
a
fundamental
process
driving
cancer
metastasis,
transforming
non-motile
cells
into
motile
population
that
migrates
to
distant
organs
and
forms
secondary
tumors.
In
recent
years,
research
has
revealed
strong
connection
between
exosomes
the
EMT.
Exosomes,
subpopulation
of
extracellular
vesicles,
facilitate
cellular
communication
dynamically
regulate
various
aspects
including
immune
cell
suppression,
matrix
remodeling,
metastasis
initiation,
EMT
organ-specific
metastasis.
Tumor-derived
(TEXs)
their
molecular
cargo,
comprising
proteins,
lipids,
nucleic
acids,
carbohydrates,
are
essential
components
promote
in
cancer.
TEXs
miRNAs
play
crucial
role
reprogramming
tumor
microenvironment,
while
TEX
surface
integrins
contribute
Exosome-based
offers
deeper
understanding
about
an
effective
theranostic
platform
development.
Additionally,
therapeutic
sources
paving
way
for
innovative
treatment
this
Review,
we
spotlight
impact,
aiming
inspire
researchers
worldwide
explore
fascinating
field
more
ways.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
As
we
progress
into
the
21st
century,
cancer
stands
as
one
of
most
dreaded
diseases.
With
approximately
in
every
four
individuals
facing
a
lifetime
risk
developing
cancer,
remains
serious
health
challenges
worldwide.
Its
multifaceted
nature
makes
it
an
arduous
and
tricky
problem
to
diagnose
treat.
Over
years,
researchers
have
explored
plenty
approaches
avenues
improve
management.
One
notable
strategy
includes
study
extracellular
vesicles
(EVs)
potential
biomarkers
therapeutics.
Among
these
EVs,
exosomes
emerged
particularly
promising
candidates
due
their
unique
characteristic
properties
functions.
They
are
small
membrane-bound
secreted
by
cells
carrying
cargo
biomolecules
such
proteins,
nucleic
acids,
lipids.
These
play
crucial
roles
intercellular
communication,
facilitating
transfer
biological
information
between
cell-to-cell
communication.
Exosomes
transport
cargoes
DNA,
RNA,
lipids
involved
cellular
reprogramming
promoting
cancer.
In
this
review,
explore
molecular
composition
exosomes,
significance
chemistry
development,
its
theranostic
application
well
research
complications
solutions.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
12(8)
Опубликована: Дек. 21, 2022
Abstract
Extracellular
vesicles
(EVs)
are
nanoscale
membrane
vesicles,
which
contain
a
wide
variety
of
cargo
such
as
proteins,
miRNAs,
and
lipids.
A
growing
body
evidence
suggests
that
EVs
promising
biomarkers
for
disease
diagnosis
therapeutic
strategies.
Although
the
excellent
clinical
value,
their
use
in
personalized
healthcare
practice
is
not
yet
feasible
due
to
highly
heterogeneous
nature.
Taking
difficulty
isolation
small
size
into
account,
characterization
at
single‐particle
level
both
imperative
challenging.
In
bid
address
this
critical
point,
more
research
has
been
directed
microfluidic
platform
because
its
inherent
advantages
sensitivity,
specificity,
throughput.
This
review
discusses
biogenesis
heterogeneity
takes
broad
view
state‐of‐the‐art
advances
microfluidics‐based
EV
research,
including
only
separation,
but
also
single
biophysical
detection
biochemical
analysis.
To
highlight
techniques,
conventional
technologies
included
comparison.
The
current
status
artificial
intelligence
(AI)
then
presented.
Furthermore,
challenges
prospects
microfluidics
combination
with
AI
applications
discussed.
foreseeable
future,
recent
breakthroughs
platforms
expected
pave
way
analysis
improve
precision
medicine.
ACS Nano,
Год журнала:
2023,
Номер
17(18), С. 17668 - 17698
Опубликована: Сен. 11, 2023
Extracellular
vesicles
(EVs)
are
extensively
dispersed
lipid
bilayer
membrane
involved
in
the
delivery
and
transportation
of
molecular
payloads
to
certain
cell
types
facilitate
intercellular
interactions.
Their
significant
roles
physiological
pathological
processes
make
EVs
outstanding
biomarkers
for
disease
diagnosis
treatment
monitoring
as
well
ideal
candidates
drug
delivery.
Nevertheless,
differences
biogenesis
among
EV
subpopulations
have
led
a
diversity
biophysical
characteristics
cargos.
Additionally,
prevalent
heterogeneity
has
been
found
substantially
hamper
sensitivity
accuracy
therapeutic
monitoring,
thus
impeding
advancement
clinical
applications.
In
recent
years,
evolution
single
(SEV)
analysis
enabled
an
in-depth
comprehension
physical
properties,
composition,
biological
at
individual
vesicle
level.
This
review
examines
sample
acquisition
tactics
prior
SEV
analysis,
i.e.,
isolation
techniques,
outlines
current
state-of-the-art
label-free
label-based
technologies
identification.
Furthermore,
challenges
prospects
biomedical
applications
based
on
systematically
discussed.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
7(1), С. 44 - 58
Опубликована: Дек. 18, 2023
Epithelial-mesenchymal
transition
(EMT)
is
a
fundamental
process
driving
cancer
metastasis,
transforming
non-motile
cells
into
motile
population
that
migrates
to
distant
organs
and
forms
secondary
tumors.
In
recent
years,
research
has
revealed
strong
connection
between
exosomes
the
EMT.
Exosomes,
subpopulation
of
extracellular
vesicles,
facilitate
cellular
communication
dynamically
regulate
various
aspects
including
immune
cell
suppression,
matrix
remodeling,
metastasis
initiation,
EMT
organ-specific
metastasis.
Tumor-derived
(TEXs)
their
molecular
cargo,
comprising
proteins,
lipids,
nucleic
acids,
carbohydrates,
are
essential
components
promote
in
cancer.
TEXs
miRNAs
play
crucial
role
reprogramming
tumor
microenvironment,
while
TEX
surface
integrins
contribute
Exosome-based
offers
deeper
understanding
about
an
effective
theranostic
platform
development.
Additionally,
therapeutic
sources
paving
way
for
innovative
treatment
this
Review,
we
spotlight
impact,
aiming
inspire
researchers
worldwide
explore
fascinating
field
more
ways.
