Role of Exosomes in Epithelial–Mesenchymal Transition DOI Creative Commons
Bikramjit Bhattacharya, Sagnik Nag, Sayantanee Mukherjee

и другие.

ACS Applied Bio Materials, Год журнала: 2023, Номер 7(1), С. 44 - 58

Опубликована: Дек. 18, 2023

Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into motile population that migrates to distant organs and forms secondary tumors. In recent years, research has revealed strong connection between exosomes the EMT. Exosomes, subpopulation of extracellular vesicles, facilitate cellular communication dynamically regulate various aspects including immune cell suppression, matrix remodeling, metastasis initiation, EMT organ-specific metastasis. Tumor-derived (TEXs) their molecular cargo, comprising proteins, lipids, nucleic acids, carbohydrates, are essential components promote in cancer. TEXs miRNAs play crucial role reprogramming tumor microenvironment, while TEX surface integrins contribute Exosome-based offers deeper understanding about an effective theranostic platform development. Additionally, therapeutic sources paving way for innovative treatment this Review, we spotlight impact, aiming inspire researchers worldwide explore fascinating field more ways.

Язык: Английский

Clinical Impact of Exosome Chemistry in Cancer DOI

Shrishti Madhan,

Rajib Dhar, Arikketh Devi

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

As we progress into the 21st century, cancer stands as one of most dreaded diseases. With approximately in every four individuals facing a lifetime risk developing cancer, remains serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose treat. Over years, researchers have explored plenty approaches avenues improve management. One notable strategy includes study extracellular vesicles (EVs) potential biomarkers therapeutics. Among these EVs, exosomes emerged particularly promising candidates due their unique characteristic properties functions. They are small membrane-bound secreted by cells carrying cargo biomolecules such proteins, nucleic acids, lipids. These play crucial roles intercellular communication, facilitating transfer biological information between cell-to-cell communication. Exosomes transport cargoes DNA, RNA, lipids involved cellular reprogramming promoting cancer. In this review, explore molecular composition exosomes, significance chemistry development, its theranostic application well research complications solutions.

Язык: Английский

Процитировано

1

From Conventional to Microfluidic: Progress in Extracellular Vesicle Separation and Individual Characterization DOI
Mingrui Chen, Shujing Lin,

Cheng Zhou

и другие.

Advanced Healthcare Materials, Год журнала: 2022, Номер 12(8)

Опубликована: Дек. 21, 2022

Abstract Extracellular vesicles (EVs) are nanoscale membrane vesicles, which contain a wide variety of cargo such as proteins, miRNAs, and lipids. A growing body evidence suggests that EVs promising biomarkers for disease diagnosis therapeutic strategies. Although the excellent clinical value, their use in personalized healthcare practice is not yet feasible due to highly heterogeneous nature. Taking difficulty isolation small size into account, characterization at single‐particle level both imperative challenging. In bid address this critical point, more research has been directed microfluidic platform because its inherent advantages sensitivity, specificity, throughput. This review discusses biogenesis heterogeneity takes broad view state‐of‐the‐art advances microfluidics‐based EV research, including only separation, but also single biophysical detection biochemical analysis. To highlight techniques, conventional technologies included comparison. The current status artificial intelligence (AI) then presented. Furthermore, challenges prospects microfluidics combination with AI applications discussed. foreseeable future, recent breakthroughs platforms expected pave way analysis improve precision medicine.

Язык: Английский

Процитировано

31

Recent advancements in nanomaterials-based aptasensors for the detection of emerging contaminants in foodstuffs DOI
Lamia Hejji, Abdelmonaim Azzouz, Deepak Kukkar

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 166, С. 117194 - 117194

Опубликована: Июль 24, 2023

Язык: Английский

Процитировано

22

Extracellular Vesicles: Techniques and Biomedical Applications Related to Single Vesicle Analysis DOI
Jie Zhang, Jiacheng Wu, Guangzhao Wang

и другие.

ACS Nano, Год журнала: 2023, Номер 17(18), С. 17668 - 17698

Опубликована: Сен. 11, 2023

Extracellular vesicles (EVs) are extensively dispersed lipid bilayer membrane involved in the delivery and transportation of molecular payloads to certain cell types facilitate intercellular interactions. Their significant roles physiological pathological processes make EVs outstanding biomarkers for disease diagnosis treatment monitoring as well ideal candidates drug delivery. Nevertheless, differences biogenesis among EV subpopulations have led a diversity biophysical characteristics cargos. Additionally, prevalent heterogeneity has been found substantially hamper sensitivity accuracy therapeutic monitoring, thus impeding advancement clinical applications. In recent years, evolution single (SEV) analysis enabled an in-depth comprehension physical properties, composition, biological at individual vesicle level. This review examines sample acquisition tactics prior SEV analysis, i.e., isolation techniques, outlines current state-of-the-art label-free label-based technologies identification. Furthermore, challenges prospects biomedical applications based on systematically discussed.

Язык: Английский

Процитировано

22

Role of Exosomes in Epithelial–Mesenchymal Transition DOI Creative Commons
Bikramjit Bhattacharya, Sagnik Nag, Sayantanee Mukherjee

и другие.

ACS Applied Bio Materials, Год журнала: 2023, Номер 7(1), С. 44 - 58

Опубликована: Дек. 18, 2023

Epithelial-mesenchymal transition (EMT) is a fundamental process driving cancer metastasis, transforming non-motile cells into motile population that migrates to distant organs and forms secondary tumors. In recent years, research has revealed strong connection between exosomes the EMT. Exosomes, subpopulation of extracellular vesicles, facilitate cellular communication dynamically regulate various aspects including immune cell suppression, matrix remodeling, metastasis initiation, EMT organ-specific metastasis. Tumor-derived (TEXs) their molecular cargo, comprising proteins, lipids, nucleic acids, carbohydrates, are essential components promote in cancer. TEXs miRNAs play crucial role reprogramming tumor microenvironment, while TEX surface integrins contribute Exosome-based offers deeper understanding about an effective theranostic platform development. Additionally, therapeutic sources paving way for innovative treatment this Review, we spotlight impact, aiming inspire researchers worldwide explore fascinating field more ways.

Язык: Английский

Процитировано

21