Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 6891 - 6952

Опубликована: Май 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Язык: Английский

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Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing

ACS Nano, Год журнала: 2023, Номер 17(16), С. 15962 - 15977

Опубликована: Авг. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Язык: Английский

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Bacteria-responsive programmed self-activating antibacterial hydrogel to remodel regeneration microenvironment for infected wound healing

National Science Review, Год журнала: 2024, Номер 11(4)

Опубликована: Янв. 29, 2024

ABSTRACT There is still an urgent need to develop hydrogels with intelligent antibacterial ability achieve on-demand treatment of infected wounds and accelerate wound healing by improving the regeneration microenvironment. We proposed a strategy hydrogel dressing bacteria-responsive self-activating property multiple nanozyme activities remodel microenvironment in order significantly promote healing. Specifically, pH-responsive H2O2 self-supplying composite (MSCO) pH/enzyme-sensitive triblock micelles encapsulated lactate oxidase (PPEL) were prepared composed L-arginine-modified chitosan (CA) phenylboronic acid-modified oxidized dextran (ODP) form cascade platform. The respond multifactorial changes bacterial metabolic biofilm eradication through transformation metabolites, chemodynamic therapy enhanced activity conjunction self-driven nitric oxide (NO) release. showed ‘self-diagnostic’ for Through infection stage self-adaptive oxidative stress relief angiogenesis post-infection stage, it promotes closure, accelerates collagen deposition angiogenesis, completely improves regeneration, which provides new method design dressings.

Язык: Английский

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Gallium Liquid Metal: Nanotoolbox for Antimicrobial Applications

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14406 - 14423

Опубликована: Июль 28, 2023

The proliferation of drug resistance in microbial pathogens poses a significant threat to human health. Hence, treatment measures are essential surmount this growing problem. In context, liquid metal nanoparticles promising. Gallium, post-transition notable for being at physiological temperature, has drawn attention its distinctive properties, high antimicrobial efficacy, and low toxicity. Moreover, gallium demonstrate anti-inflammatory properties immune cells. Gallium can alloy with other metals be prepared various composites modify tailor characteristics functionality. More importantly, the bactericidal mechanism could sidestep emerging mechanisms. Building on rationale, gallium-based enable impactful innovative strategic pathways battle against resistance. This review outlines nanoscale their corresponding mechanisms provide comprehensive yet succinct overview current applications. addition, challenges opportunities that require further research efforts have been identified discussed.

Язык: Английский

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Nanomaterials-Based Wound Dressing for Advanced Management of Infected Wound

Antibiotics, Год журнала: 2023, Номер 12(2), С. 351 - 351

Опубликована: Фев. 8, 2023

The effective prevention and treatment of bacterial infections is imperative to wound repair the improvement patient outcomes. In recent years, nanomaterials have been extensively applied in infection control healing due their special physiochemical biological properties. Incorporating antibacterial into dressing has associated with improved biosafety enhanced outcomes compared naked nanomaterials. this review, we discuss progress application nanomaterial-based dressings for advanced management infected wounds. Focus given therapy as well all-in-one detection infections. Notably, highlight use nanoparticles intrinsic performances, such metals metal oxide that are capable killing bacteria reducing drug-resistance through multiple antimicrobial mechanisms. addition, proven be ideal drug carriers delivery release antimicrobials either passive or stimuli-responsive manners. ability kill based on photo-triggered heat (photothermal therapy) ROS (photodynamic therapy), unparalleled advantages control. Moreover, examples intelligent can detect in-situ while providing timely Finally, challenges current provide further perspectives future healing.

Язык: Английский

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Metal-Based Nanoparticles as Antimicrobial Agents: A Review

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(3), С. 2529 - 2545

Опубликована: Янв. 18, 2024

Antibiotic abuse has become a rising public health concern in recent years, leading to dangerous bacteria developing antibiotic resistance most medicines currently use. Traditional antimicrobial medications have been helpful the early stages of treating numerous forms serious bacterial infectious diseases; however, despite significant therapeutic benefit, there are number issues with follow-up treatment. Metal-based nanomaterials, which properties including difficulty establishing drug and advantages reduced cytotoxicity, considered promising substances. This review discusses important types metal-based nanoparticles (MNPs), such as copper, titanium, zinc oxide, etc., focus on applications gold- silver-based nanoparticles. Furthermore, advanced research progress MNPs agents stimuli-responsive metal nanoparticle strategies working under photothermal, magnetic, pH stimulation also summarized this article. In general, advancement technology, materials based will offer excellent prospects for improving applications.

Язык: Английский

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Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Год журнала: 2024, Номер 34(38)

Опубликована: Апрель 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Язык: Английский

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New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 4, 2024

Abstract Periodontitis is a chronic inflammatory disease caused by the local microbiome and host immune response, resulting in periodontal structure damage even tooth loss. Scaling root planning combined with antibiotics are conventional means of nonsurgical treatment periodontitis, but they insufficient to fully heal periodontitis due intractable bacterial attachment drug resistance. Novel effective therapeutic options clinical therapy remain scarce. Nanotherapeutics achieve stable cell targeting, oral retention smart release great flexibility changing chemical composition or physical characteristics nanoparticles. Meanwhile, protectiveness high surface area volume ratio nanoparticles enable loading, ensuring remarkable efficacy. Currently, combination advanced novel strategies most active research treatment. In this review, we first introduce pathogenesis then summarize state-of-the-art nanotherapeutic based on triple concerto antibacterial activity, immunomodulation periodontium regeneration, particularly focusing mechanism ingenious design nanomedicines. Finally, challenges prospects nano for discussed from perspective current problems future development trends. Graphical

Язык: Английский

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Progress of stimulus responsive nanosystems for targeting treatment of bacterial infectious diseases

Advances in Colloid and Interface Science, Год журнала: 2024, Номер 324, С. 103078 - 103078

Опубликована: Янв. 5, 2024

Язык: Английский

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Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant Staphylococcus aureus-Induced Osteomyelitis

ACS Nano, Год журнала: 2025, Номер 19(5), С. 5253 - 5268

Опубликована: Янв. 31, 2025

Methicillin-resistant Staphylococcus aureus (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn2+ vancomycin (Van) codelivered nanotherapeutic (named Man-Zn2+/Van NPs) was fabricated characterized via mannose (Man) modification. NPs exhibit significant inhibitory activity against extra- MRSA obviously decrease minimum concentration Van. can be easily internalized by MRSA-infected macrophages significantly accumulated in infected bone Man-mediated targeting. In vivo experiments mouse OM model verified that reduce burden, improve gait patterns, mass, inflammatory cytokine expression. The antibacterial mechanism includes destruction membrane, degeneration proteins DNA, inhibition glycolysis, intervention energy metabolism bacteria. Overall, this metal-antibiotic nanotherapeutics strategy provides new insight for combating infections caused MRSA-induced OM.

Язык: Английский

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