ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(4), С. 4228 - 4238
Опубликована: Фев. 5, 2024
The
preparation
and
property
studies
of
long-wavelength-emitting
carbon
dots
(CDs)
nanozymes
with
multifunctions
like
multienzyme
activity
nanozymes,
antibacterial,
antioxidation
have
promising
prospects
in
biochemical
detection
clinical
fields.
This
paper
reports
the
fast
dual
enzyme-like
active
yellow-green
quantum
(4-ASA/Gd-CDs)
through
a
one-step
hydrothermal
route
rare-earth
element
Gd
doping,
4-aminosalicylic
acid
(4-ASA),
polyethyleneimine
(PEI)
as
raw
materials.
prepared
CDs
can
produce
O2•–
under
irradiation
UV
light
rapidly
oxidize
colorless
substrate
o-phenylenediamine
(OPD)
into
yellow
2,3-diaminophenazine
(oxOPD);
meanwhile,
heavy
metal
Cu2+
strongly
coordinate
CDs,
leading
to
electron
transfer
inhibition
CDs-like
oxidative
enzyme
activity,
finally
realize
real-time
colorimetric
Cu2+.
limit
was
low
0.38
μM
(3σ/k)
dynamic
range
from
0
38.4
μM.
Moreover,
portable
hydrogels
(CDs-OPD-PSA)
were
also
prepared,
visual
achieved
assistance
smartphone.
experiment
showed
that
4-ASA/Gd-CDs
exhibited
excellent
antibacterial
ability
superoxide
dismutase
(SOD)-like
activity.
mechanisms
against
gram-negative/positive
bacteria
investigated
potential
value
its
own
antioxidant
MICs
G+
Staphylococcus
aureus
Bacillus
subtilis
are
30
17
μg/mL,
respectively,
those
G–
Escherichia
coli
Pseudomonas
aeruginosa
210
35
respectively.
research
would
provide
an
theoretical
practical
basis
for
synthesis
their
application
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(33)
Опубликована: Май 6, 2024
Abstract
Diabetic
foot
ulcers
(DFUs),
a
serious
and
increasingly
common
chronic
issue
among
diabetics,
often
do
not
respond
well
to
generalized
treatment
strategies.
Hypoxia
the
overexpression
of
reactive
oxygen
species
(ROS),
resulting
in
inflammatory
dysregulation
subsequent
imbalance
macrophage
phenotypes,
are
critical
factors
contributing
prolonged
non‐healing
DFU
wounds.
These
two
issues
interact
continuous,
problematic
cycle.
Presently,
there
is
lack
comprehensive
strategies
aimed
at
addressing
both
these
simultaneously
interrupt
this
detrimental
Herein,
an
immunomodulatory
hydrogel
(PHG2)
developed
for
reshaping
hostile
microenvironment.
The
engineered
PHG2
only
removes
excess
internally‐produced
ROS
but
also
generates
O
2
,
with
its
efficiency
further
boosted
by
local
hyperthermia
(42.5
°C)
activated
near‐infrared
light.
Through
vitro
vivo
studies,
along
transcriptomic
assessment,
it
confirmed
that
disrupts
feedback
loop
between
inflammation
while
lowering
M1/M2
ratio.
Such
discoveries
contribute
significant
enhancement
healing
process
injuries
undergo
gradual
increase
movement,
covering
wounds
from
back,
mouth,
foot.
Ultimately,
method
provides
easy,
safe,
highly
effective
solution
treating
DFUs.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(7), С. 2533 - 2547
Опубликована: Май 24, 2024
Contemporary
options
for
multidrug-resistant
bacteria
infected
diabetic
foot
ulcers
(IDFUs)
are
predominantly
nonspecific.
These
IDFU
injuries
often
display
prolonged
inflammation
and
delayed
tissue
repair,
mainly
attributed
to
an
overabundance
of
M1
macrophages
in
the
hostile
microenvironment.
Although
immunomodulatory
hydrogels
show
promise
IDFU-focused
care,
a
targeted,
safe
transition
from
M2
using
simplified
techniques
remains
significant
obstacle.
Here,
we
introduce
hybrid
hydrogel
(GGG)
with
inherent
capabilities
IDFUs.
GGG
is
composed
interpenetrating
polymer
networks
featuring
gallium-induced
self-assembling
glycyrrhizic
acid
photo-cross-linked
gelatin
methacryloyl
matrix.
Importantly,
effectively
decreases
ratio
conditions
drug-resistant
by
disrupting
iron
metabolism
scavenging
reactive
oxygen
species,
which
contributes
enhanced
treatment
results
wounds.
To
sum
up,
strategy
present
provides
straightforward,
safe,
highly
effective
therapeutic
avenue
managing
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 16, 2024
Abstract
Diabetic
wounds
are
difficult
to
heal,
and
the
key
wound
healing
is
exudate
management
effective
disinfection.
Inspired
by
asymmetric
wettability
of
Janus‐structured
lotus
leaves,
herein
study
has
presented
design
a
biomimetic
Janus
membrane
that
integrates
unidirectional
biofluid
drainage
photothermal‐enhanced
evaporation/sterilization
capabilities
for
accelerating
diabetic
healing.
This
prepared
electrospinning
polyacrylonitrile
(PAN)
nanofiber
containing
polydopamine
(PDA)
on
surface
polypropylene
(PP)
nonwoven
membrane.
Such
PP/PAN
x%PDA
enables
antigravity
“pumping”
water
from
hydrophobic
PP
layer
hydrophilic
PAN
within
22
s
through
contact
points
interface.
The
incorporation
30
wt%
PDA
in
imparts
high
photoabsorption
photothermal
responsiveness,
facilitating
continuous
volatilization
exudate,
achieving
twice
displacement
water,
causing
irreversible
damage
bacteria.
As
result,
it
effectively
alleviates
inflammation
cellular
fibrosis
while
promoting
collagen
deposition
due
its
structure
antibacterial
properties.
Impressively,
such
achieves
an
impressive
closure
rate
96.7%
wounds,
better
than
(59.8%)
conventional
bandages.
Therefore,
this
offers
promising
alternative
chronic
wounds.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Фев. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(15), С. 10478 - 10488
Опубликована: Апрель 5, 2024
During
biomedical
applications,
nanozymes,
exhibiting
enzyme-like
characteristics,
inevitably
come
into
contact
with
biological
fluids
in
living
systems,
leading
to
the
formation
of
a
protein
corona
on
their
surface.
Although
it
is
acknowledged
that
molecular
adsorption
can
influence
catalytic
activity
there
dearth
understanding
regarding
impact
nanozyme
and
its
determinant
factors.
In
order
address
this
gap,
we
employed
AuNR@Pt@PDDAC
[PDDAC,
poly(diallyldimethylammonium
chloride)]
nanorod
(NR)
as
model
multiple
activities,
including
peroxidase,
oxidase,
catalase-mimetic
investigate
inhibitory
effects
activity.
After
identification
major
components
plasma
NR,
observed
spherical
proteins
fibrous
induced
distinct
nanozymes.
To
elucidate
underlying
mechanism,
uncovered
adsorbed
assembled
surface
forming
networks
(PNs).
Notably,
PNs
derived
from
exhibited
screen
mesh-like
structure
smaller
pore
sizes
compared
those
formed
by
proteins.
This
structural
disparity
resulted
reduced
efficiency
for
permeation
substrate
molecules,
more
robust
inhibition
These
findings
underscore
significance
shape
crucial
factor
influencing
revelation
provides
valuable
insights
rational
design
application
nanozymes
fields.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Июль 2, 2024
Abstract
Chronic
diabetic
wounds
confront
a
significant
medical
challenge
because
of
increasing
prevalence
and
difficult-healing
circumstances.
It
is
vital
to
develop
multifunctional
hydrogel
dressings,
with
well-designed
morphology
structure
enhance
flexibility
effectiveness
in
wound
management.
To
achieve
these,
we
propose
self-healing
dressing
based
on
structural
color
microspheres
for
The
microsphere
comprised
photothermal-responsive
inverse
opal
framework,
which
was
constructed
by
hyaluronic
acid
methacryloyl,
silk
fibroin
methacryloyl
black
phosphorus
quantum
dots
(BPQDs),
further
re-filled
dynamic
hydrogel.
filler
formed
Knoevenagel
condensation
reaction
between
cyanoacetate
benzaldehyde-functionalized
dextran
(DEX-CA
DEX-BA).
Notably,
the
composite
can
be
applied
arbitrarily,
they
adhere
together
upon
near-infrared
irradiation
leveraging
BPQDs-mediated
photothermal
effect
thermoreversible
stiffness
change
Additionally,
eumenitin
vascular
endothelial
growth
factor
were
co-loaded
their
release
behavior
regulated
same
mechanism.
Moreover,
effective
monitoring
drug
process
achieved
through
visual
variations.
system
has
demonstrated
desired
capabilities
controllable
efficient
These
characteristics
suggest
broad
prospects
proposed
clinical
applications.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 6, 2024
Abstract
Nanozyme,
characterized
by
outstanding
and
inherent
enzyme-mimicking
properties,
have
emerged
as
highly
promising
alternatives
to
natural
enzymes
owning
their
exceptional
attributes
such
regulation
of
oxidative
stress,
convenient
storage,
adjustable
catalytic
activities,
remarkable
stability,
effortless
scalability
for
large-scale
production.
Given
the
potent
regulatory
function
nanozymes
on
stress
coupled
with
fact
that
reactive
oxygen
species
(ROS)
play
a
vital
role
in
occurrence
exacerbation
metabolic
diseases,
nanozyme
offer
unique
perspective
therapy
through
multifunctional
achieving
essential
results
treatment
diseases
directly
scavenging
excess
ROS
or
regulating
pathologically
related
molecules.
The
rational
design
strategies,
nanozyme-enabled
therapeutic
mechanisms
at
cellular
level,
therapies
several
typical
underlying
are
discussed,
mainly
including
obesity,
diabetes,
cardiovascular
disease,
diabetic
wound
healing,
others.
Finally,
pharmacokinetics,
safety
analysis,
challenges,
outlooks
application
also
presented.
This
review
will
provide
some
instructive
perspectives
promote
development
strategies
disease
therapy.
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