Abstract
Rational
design
of
highly
active
and
stable
catalysts
for
dopamine
oxidation
is
still
a
great
challenge.
Herein,
inspired
by
the
catalytic
pocket
natural
enzymes,
an
iodine
(I)‐doped
single
Fe‐site
catalyst
(I/Fe
SA
NC)
synthesized
to
mimic
center
heme
enzymes
in
both
geometrical
electronic
structures,
aiming
enhance
(DA)
oxidation.
Experimental
studies
theoretical
calculations
show
that
communication
between
I
FeN
5
effectively
modulates
structure
site,
greatly
optimizing
overlap
Fe
3d
O
2p
orbitals,
thereby
enhancing
OH
adsorption.
In
addition,
induced
doping
attenuates
attack
proton
hydrogen
on
center,
stability
I/Fe
NC.
This
work
provides
new
insights
into
single‐atom
enhances
understanding
mechanisms
DA
at
atomic
scale.
ECS Sensors Plus,
Год журнала:
2024,
Номер
3(2), С. 020601 - 020601
Опубликована: Апрель 1, 2024
Dopamine
is
an
essential
neurotransmitter
for
daily
cognitive
functions
controlling
many
neurophysiological
processes
including
memory,
cognition,
and
physical
control.
Development
of
analytical
methods
sensors
to
detect
dopamine
important
health
monitoring
neurological
research.
This
review
provides
overview
recent
advances
in
the
development
electrochemical
catalytic
biosensors
based
on
enzyme
enzyme-mimetic
materials
discusses
their
potential
applications
measurements
biological
fluids.
The
first
part
summarizes
critically
assesses
different
types
enzymes
mimetic
that
can
be
used
catalytically
convert
dopamine,
followed
by
a
discussion
biosensor’s
fabrication,
key
design
parameters,
detection
mechanism
various
electrode
platforms
ranging
from
single-use
screen-printed
electrodes
microneedles
implantable
microelectrodes.
second
examples
samples,
saliva,
urine,
serum,
cell
cultures,
brain
tissue.
We
conclude
with
summary
advantages
limitations
these
devices
clinical
field,
outlook
future
research
towards
implementation
broader
adoption
neurophysiology,
pharmacology,
field.
Chemical Reviews,
Год журнала:
2024,
Номер
124(5), С. 2205 - 2280
Опубликована: Фев. 21, 2024
Advances
in
soft
materials,
miniaturized
electronics,
sensors,
stimulators,
radios,
and
battery-free
power
supplies
are
resulting
a
new
generation
of
fully
implantable
organ
interfaces
that
leverage
volumetric
reduction
mechanics
by
eliminating
electrochemical
storage.
This
device
class
offers
the
ability
to
provide
high-fidelity
readouts
physiological
processes,
enables
stimulation,
allows
control
over
organs
realize
therapeutic
diagnostic
paradigms.
Driven
seamless
integration
with
connected
infrastructure,
these
devices
enable
personalized
digital
medicine.
Key
advances
carefully
designed
material,
electrophysical,
electrochemical,
electromagnetic
systems
form
implantables
mechanical
properties
closely
matched
target
deliver
functionality
supports
sensors
stimulators.
The
elimination
operation,
anywhere
from
acute,
lifetimes
matching
subject
physical
dimensions
imperceptible
operation.
review
provides
comprehensive
overview
basic
building
blocks
related
topics
such
as
implantation,
delivery,
sterilization,
user
acceptance.
State
art
examples
categorized
system
an
outlook
interconnection
advanced
strategies
for
computation
leveraging
consistent
influx
elevate
this
current
battery-powered
is
highlighted.
ACS Nano,
Год журнала:
2024,
Номер
18(15), С. 10596 - 10608
Опубликована: Апрель 1, 2024
Continuously
monitoring
neurotransmitter
dynamics
can
offer
profound
insights
into
neural
mechanisms
and
the
etiology
of
neurological
diseases.
Here,
we
present
a
miniaturized
implantable
fluorescence
probe
integrated
with
metal-organic
frameworks
(MOFs)
for
deep
brain
dopamine
sensing.
The
is
assembled
from
physically
thinned
light-emitting
diodes
(LEDs)
phototransistors,
along
functional
surface
coatings,
resulting
in
total
thickness
120
μm.
A
fluorescent
MOF
that
specifically
binds
introduced,
enabling
highly
sensitive
measurement
detection
limit
79.9
nM.
compact
wireless
circuit
weighing
only
0.85
g
also
developed
interfaced
probe,
which
was
later
applied
to
continuously
monitor
real-time
levels
during
stimulation
rats,
providing
critical
information
on
dynamics.
Cytotoxicity
tests
immunofluorescence
analysis
further
suggest
favorable
biocompatibility
applications.
This
work
presents
fundamental
principles
techniques
integrating
MOFs
flexible
electronics
brain-computer
interfaces
may
provide
more
customized
platforms
applications
neuroscience,
disease
tracing,
smart
diagnostics.
Advanced Materials,
Год журнала:
2023,
Номер
35(23)
Опубликована: Март 10, 2023
3D
stretchable
electronics
attract
growing
interest
due
to
their
new
and
more
complex
functionalities
compared
1D
or
2D
counterparts.
Among
all
configuration
designs,
a
helical
structure
is
commonly
used
as
it
can
be
designed
achieve
outstanding
stretching
ratios
well
highly
robust
mechanical
performance.
However,
the
ratio
that
mainly
focuses
on
axis
direction
hinders
its
applications.
Inspired
by
hierarchies
in
tendon,
novel
structural
design
of
hierarchical
serpentine-helix
combination
proposed.
The
constructed
sequence
with
repeating
small
units
winding
manner
around
enable
large
forces
transferred
down
smaller
scale
dissipation
potentially
damaging
stresses
microscale
buckling,
thereby
endowing
electronic
components
made
from
high-performance
but
hard-to-stretch
materials
stretchability
(≥200%)
x-,
y-,
z-axis
direction,
high
stability,
extraordinary
electromechanical
Two
applications
including
wireless
charging
patch
an
epidermal
system
are
demonstrated.
several
combinations
allows
for
high-fidelity
monitoring
electrophysiological
signals,
galvanic
skin
response,
finger-movement-induced
electrical
which
good
tactile
pattern
recognition
when
combined
artificial
neural
network.
ACS Nano,
Год журнала:
2024,
Номер
18(10), С. 7485 - 7495
Опубликована: Фев. 28, 2024
Homovanillic
acid
(HVA)
is
a
major
dopamine
metabolite,
and
blood
HVA
considered
as
central
nervous
system
(CNS)
biomarker,
which
reflects
the
progression
of
dopamine-associated
CNS
diseases
behavioral
response
to
therapeutic
drugs.
However,
facing
various
active
substances
interference,
particularly
structurally
similar
catecholamines
their
metabolites,
real-time
accurate
monitoring
remains
challenge.
Herein,
highly
selective
implantable
electrochemical
fiber
sensor
based
on
molecularly
imprinted
polymer
reported
accurately
monitor
in
vivo.
The
exhibits
high
selectivity,
with
intensity
12.6
times
greater
than
that
achieving
97.8%
accuracy
injected
into
rat
caudal
vein
tracked
changes
HVA,
paralleled
brain
fluctuations
indicated
increase.
This
study
provides
universal
design
strategy
for
improving
selectivity
sensors.
Device,
Год журнала:
2024,
Номер
2(6), С. 100421 - 100421
Опубликована: Июнь 1, 2024
In
robotics
and
AI-based
systems,
there
is
a
demand
for
sensors
with
efficient
targeted
multifunctionalities.
The
emergence
of
triboelectric
presents
avenues
to
meet
these
demands.
This
study
introduces
an
approach
by
integrating
smart
thermosensitive
nanosensors
into
robotic
platform,
which
facilitates
material
recognition
through
the
contact
electrification
process.
Equipped
self-powered
tactile
awareness,
fingers
provide
accurate
identification
"touch
sense"
mechanism.
sensor
features
micropyramidal
structures
in
Ecoflex-based
encapsulation
layers,
NaCl
solution
as
electrolyte
conductor.
configuration
enhances
stretchability
sustains
sensitivity.
Moreover,
due
multifunctional
sensing
capability
sensors,
this
can
be
utilized
bionic
prosthesis
systems
receptors.
integration
employed
cost-effective
automated
sensing,
aiding
identification.
