bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 21, 2024
Abstract
Wound
healing
presents
a
significant
challenge
in
biomedical
science,
requiring
precise
therapeutic
delivery
and
real-time
monitoring.
Bioelectronic
systems
offer
promising
solution
but
remain
largely
unexplored
for
wound
care,
particularly
large
animal
models
that
reflect
human
dynamics.
This
study
introduces
remote
controlled
wireless
bioelectronic
platform
equipped
with
an
iontophoretic
pump
to
deliver
fluoxetine,
selective
serotonin
reuptake
inhibitor
promotes
repair.
In
vitro
ex-vivo
testing
validated
efficient
on
demand
fluoxetine
delivery.
vivo
experiments
porcine
model
demonstrated
clear
efficacy
over
3-day
7-day
periods.
The
system
enhanced
outcomes,
increasing
re-epithelialization
by
37%
(H&E
staining),
reducing
the
M1/M2
macrophage
ratio
33%,
stimulating
neuronal
growth
at
site.
delivers
controlled,
remotely-controlled
manner
while
allowing
direct
imaging
can
be
used
monitor
progress.
Additionally,
it
allows
dose
temporal
of
treatment
enhance
outcome
future
studies.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(15), С. 7960 - 7982
Опубликована: Янв. 1, 2024
This
review
discusses
the
advancements,
sensor
design,
and
challenges
in
creating
wearable
implantable
nucleic
acid-based
sensors
for
personalized
healthcare
through
real-time
biomarker
analysis
biofluids.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Bioelectronic
implantable
devices
are
adept
at
facilitating
continuous
monitoring
of
health
and
enabling
the
early
detection
diseases,
offering
insights
into
physiological
conditions
various
bodily
organs.
Furthermore,
these
advanced
systems
have
therapeutic
capabilities
in
neuromodulation,
demonstrating
their
efficacy
addressing
diverse
medical
through
precise
delivery
stimuli
directly
to
specific
targets.
This
comprehensive
review
explores
developments
applications
bioelectronic
within
biomedical
field.
Special
emphasis
is
placed
on
evolution
closed‐loop
systems,
which
stand
out
for
dynamic
treatment
adjustments
based
real‐time
feedback.
The
integration
Artificial
Intelligence
(AI)
edge
computing
technologies
discussed,
significantly
bolster
diagnostic
functions
devices.
By
elemental
analyses,
current
challenges,
future
directions
devices,
aims
guide
pathway
advances
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Янв. 9, 2025
Abstract
Recent
advancements
in
passive
wireless
sensor
technology
have
significantly
extended
the
application
scope
of
sensing,
particularly
challenging
environments
for
monitoring
industry
and
healthcare
applications.
These
systems
are
equipped
with
battery-free
operation,
connectivity,
designed
to
be
both
miniaturized
lightweight.
Such
features
enable
safe,
real-time
industrial
support
high-precision
physiological
measurements
confined
internal
body
spaces
on
wearable
epidermal
devices.
Despite
exploration
into
diverse
environments,
development
a
systematic
comprehensive
research
framework
system
architecture
remains
elusive,
which
hampers
further
optimization
these
systems.
This
review,
therefore,
begins
an
examination
scenarios,
progresses
evaluate
current
architectures,
discusses
function
each
component—specifically,
module,
communication
model,
readout
module—within
context
key
implementations
target
sensing
Furthermore,
we
present
case
studies
that
demonstrate
feasibility
proposed
classified
components
derived
from
this
approach.
By
outlining
trajectory
technologies,
paper
aims
establish
foundation
more
advanced,
user-friendly
Nano Trends,
Год журнала:
2024,
Номер
7, С. 100042 - 100042
Опубликована: Июнь 18, 2024
Piezoelectricity
has
emerged
as
a
pivotal
platform
technology
in
bioengineering
to
advance
cardiac
healthcare.
Unlike
common
pacemakers,
these
devices
capitalize
on
the
mechanical
energy
derived
from
movements
power
themselves,
presenting
sustainable
alternative
battery
constraints
faced
by
current
implantable
devices.
This
review
explores
advances
piezoelectric
nanogenerators
for
monitoring
and
therapy,
highlighting
their
capabilities
not
only
track
activity,
but
also
provide
therapeutic
interventions
reliable
pacemakers.
It
discusses
electric
stimulation
effects
biocompatible
integration
with
human
biology,
positioning
at
forefront
of
healthcare
solutions,
thereby
enhancing
effectiveness,
durability,
personalized
care.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 16, 2025
Abstract
Traditional
intracranial
pressure
(ICP)
monitoring
methods,
using
intraventricular
catheters,
face
significant
limitations,
including
high
invasiveness,
discrete
data,
calibration
complexities,
and
drift
issues,
which
hinder
long‐term
stable
monitoring.
Here,
a
non‐surgical,
in‐stent
membrane
bioelectronic
system
is
presented
for
continuous
reliable
ICP
This
platform
integrates
capacitive
thin‐film
sensor
with
stent,
enabling
precise
real‐time
detection
of
fluctuations
directly
within
the
dural
venous
sinus
without
requiring
skull
penetration
or
frequent
recalibration.
The
demonstrates
sensitivity
0.052%/mmHg
broad,
readable
range
3–30
mmHg
while
maintaining
calibration‐free
drift‐free
performance.
A
series
in
vivo
studies
highlight
system's
superior
sensitivity,
rapid
sampling
rate,
stability
compared
to
conventional
microcatheters.
Statistical
analyses
reveal
strong
agreement
between
device
clinical
reference,
underscoring
its
potential
revolutionize
These
advancements
pave
way
broader
applications,
minimizing
complications
improving
patient
outcomes
neurocritical
care.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Abstract
Recent
advancements
in
wearable
photonic
sensors
have
marked
a
transformative
era
healthcare,
enabling
non‐invasive,
real‐time,
portable,
and
personalized
medical
monitoring.
These
leverage
the
unique
properties
of
light
toward
high‐performance
sensing
form
factors
optimized
for
real‐world
use.
Their
ability
to
offer
solutions
broad
spectrum
challenges
–
from
routine
health
monitoring
managing
chronic
conditions,
inspires
rapidly
growing
translational
market.
This
review
explores
design
development
various
healthcare
applications.
The
strategies
that
power
these
technologies
are
first
presented,
alongside
discussion
define
optimal
use‐cases
each
approach.
means
by
which
mechanisms
integrated
into
formats
then
discussed,
with
considerations
material
selection
comfort
functionality,
component
fabrication,
management.
developments
space
detailed,
accounting
both
physical
chemical
stimuli
detection
through
non‐invasive
biofluids.
Finally,
comprehensive
situational
overview
identifies
critical
translation,
promising
solutions.
Associated
future
outlooks
detail
emerging
trends
stand
enable
integration
mainstream
practice,
advancing
medicine
improving
patient
outcomes.
Applied Physics Reviews,
Год журнала:
2025,
Номер
12(1)
Опубликована: Фев. 12, 2025
Capacitive
tactile
sensors
have
garnered
significant
attention
due
to
their
simple
structure,
temperature
independence,
and
wide
applicability.
However,
with
the
continuous
evolution
of
intellectualization
process,
developing
that
can
compare
or
even
surpass
sensing
ability
human
skin
remains
a
challenge.
Consequently,
various
strategies
aimed
at
enhancing
performance
emerged,
introduction
morphological
structures
into
active
layer
being
most
effective.
In
light
this,
capacitive
based
on
structure
designs
gained
favor
among
researchers,
gradually
forming
“hundred
schools
thought
contend”
trend.
Nevertheless,
processes
applicability
yet
form
complete
system,
development
intelligence
morphological-engineering-based
reached
bottleneck
stage,
requiring
comprehensive
systematic
review
provide
inspiration
for
breakthroughs.
This
delves
deeply
impact
device
provides
overview
applicability,
advantages,
disadvantages
fabrication
technologies
derived
from
these
structures.
Finally,
progress
in
advanced
intelligent
systems
is
summarized,
challenges
prospects
faced
this
emerging
field
are
envisioned.
Chemical Product and Process Modeling,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Abstract
This
article
studies
the
application
of
biomimetic
triangular
non-smooth
surface
materials
in
automotive
acoustic
packaging
and
their
effects
on
sound
absorption
insulation
performance.
Firstly,
Statistical
Energy
Analysis
(SEA)
predicting
high-frequency
vibration
noise
automobiles
was
discussed.
Due
to
limitations
finite
element
method
noise,
SEA
has
gradually
been
widely
applied
continuously
improved
domestic
foreign
research.
establishes
models
for
front
panel
floor.
It
analyzes
performance
different
through
simulation,
focusing
materials.
The
experimental
results
show
that
material
with
a
three-layer
structure
excellent
range.
Specifically,
cowl
floor
adopts
composed
organic
fiber,
molded
felt,
polyurethane
foam
felt.
simulation
PU
bionic
wedge
coefficient
0.983
at
1,000
Hz,
significantly
better
than
traditional
smooth
material.
In
addition,
increased
by
2.9
dB
48.1
dB,
respectively,
5,000
Hz.
