NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Фев. 19, 2024

The formation of blood vessel system under a relatively higher Cu

Язык: Английский

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Discovery of Novel Tofacitinib–ADTOH Molecular Hybridization Derivatives for the Treatment of Ulcerative Colitis

Antioxidants, Год журнала: 2025, Номер 14(3), С. 325 - 325

Опубликована: Март 8, 2025

The treatment of ulcerative colitis (UC) has been a major medical challenge due to the lack safe and effective drugs. Molecular hybridization is promising strategy for development drugs with pleiotropic activity, which demonstrated in wide range diseases. Tofacitinib exhibited significant effects on remission UC, but series adverse have occurred during its clinical application. Herein, we propose utilize molecular link tofacitinib cytoprotective H2S donor (ADTOH) obtain hybridized molecules ZX-4C~ZX-6C. Among them, ZX-4C best performance release rate against dextran sulfate sodium (DSS)-induced injury. vivo studies showed that could effectively alleviate DSS-induced by enhancing oxidative stress defense reducing inflammatory response, demonstrating it more potent than parent data from present study support this provides avenue UC.

Язык: Английский

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Characterization and Evaluation Techniques for Core-Shell Nanoconstructs for Cancer Theragnostics

Опубликована: Янв. 1, 2025

Язык: Английский

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Multi-functional lipid nanoformulations for enhancing the efficacy of mRNA tumor vaccines by reversing tumor immunosuppressive microenvironment

Nano Today, Год журнала: 2025, Номер 63, С. 102757 - 102757

Опубликована: Апрель 14, 2025

Язык: Английский

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Co-delivery of three synergistic chemotherapeutics in a core-shell nanoscale coordination polymer for the treatment of pancreatic cancer

Biomaterials, Год журнала: 2023, Номер 301, С. 122235 - 122235

Опубликована: Июль 1, 2023

Язык: Английский

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