Co-delivery of three synergistic chemotherapeutics in a core-shell nanoscale coordination polymer for the treatment of pancreatic cancer DOI Creative Commons
Xiaomin Jiang, Morten J. Lee, Taokun Luo

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122235 - 122235

Published: July 1, 2023

Language: Английский

NIR-IIb fluorescence antiangiogenesis copper nano-reaper for enhanced synergistic cancer therapy DOI Creative Commons
Wenling Li,

Huan Xin,

Wenjuan Gao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 19, 2024

The formation of blood vessel system under a relatively higher Cu

Language: Английский

Citations

4
Discovery of Novel Tofacitinib–ADTOH Molecular Hybridization Derivatives for the Treatment of Ulcerative Colitis DOI Creative Commons
Yi Mou,

Shuai Wen,

Yan Wang

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 325 - 325

Published: March 8, 2025

The treatment of ulcerative colitis (UC) has been a major medical challenge due to the lack safe and effective drugs. Molecular hybridization is promising strategy for development drugs with pleiotropic activity, which demonstrated in wide range diseases. Tofacitinib exhibited significant effects on remission UC, but series adverse have occurred during its clinical application. Herein, we propose utilize molecular link tofacitinib cytoprotective H2S donor (ADTOH) obtain hybridized molecules ZX-4C~ZX-6C. Among them, ZX-4C best performance release rate against dextran sulfate sodium (DSS)-induced injury. vivo studies showed that could effectively alleviate DSS-induced by enhancing oxidative stress defense reducing inflammatory response, demonstrating it more potent than parent data from present study support this provides avenue UC.

Language: Английский

Citations

0
Characterization and Evaluation Techniques for Core-Shell Nanoconstructs for Cancer Theragnostics DOI
Ashish Kumar Parashar, Gaurav K. Saraogi, Vandana Arora Sethi

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multi-functional lipid nanoformulations for enhancing the efficacy of mRNA tumor vaccines by reversing tumor immunosuppressive microenvironment DOI
Yufeng Zhang, Liuwei Zhang, Hui Gao

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102757 - 102757

Published: April 14, 2025

Language: Английский

Citations

0
Co-delivery of three synergistic chemotherapeutics in a core-shell nanoscale coordination polymer for the treatment of pancreatic cancer DOI Creative Commons
Xiaomin Jiang, Morten J. Lee, Taokun Luo

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 301, P. 122235 - 122235

Published: July 1, 2023

Language: Английский

Citations

10