Flexible and Stretchable Light-Emitting Diodes and Photodetectors for Human-Centric Optoelectronics

Chemical Reviews, Год журнала: 2024, Номер 124(3), С. 768 - 859

Опубликована: Янв. 19, 2024

Optoelectronic devices with unconventional form factors, such as flexible and stretchable light-emitting or photoresponsive devices, are core elements for the next-generation human-centric optoelectronics. For instance, these deformable can be utilized closely fitted wearable sensors to acquire precise biosignals that subsequently uploaded cloud immediate examination diagnosis, also used vision systems human-interactive robotics. Their inception was propelled by breakthroughs in novel optoelectronic material technologies device blueprinting methodologies, endowing flexibility mechanical resilience conventional rigid devices. This paper reviews advancements soft technologies, honing on various materials, manufacturing techniques, design strategies. We will first highlight general approaches fabrication, including appropriate selection substrate, electrodes, insulation layers. then focus materials diodes, their integration strategies, representative application examples. Next, we move photodetectors, highlighting state-of-the-art fabrication methods, followed At end, a brief summary given, potential challenges further development of functional discussed conclusion.

Язык: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Год журнала: 2023, Номер 32, С. 66 - 97

Опубликована: Сен. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Язык: Английский

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Advances in Hydrogel-Based Drug Delivery Systems

Gels, Год журнала: 2024, Номер 10(4), С. 262 - 262

Опубликована: Апрель 13, 2024

Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability hydrogels to absorb and retain significant volumes water, coupled structural integrity responsiveness environmental stimuli, renders them ideal for drug delivery, tissue engineering, wound healing. This review delves into the classification based on cross-linking methods, providing insights synthesis, properties, We further discuss recent advancements in hydrogel-based delivery systems, including oral, injectable, topical, ocular approaches, highlighting significance enhancing therapeutic outcomes. Additionally, we address challenges faced clinical translation propose future directions leveraging potential personalized medicine regenerative healthcare solutions.

Язык: Английский

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Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Bioactive Materials, Год журнала: 2024, Номер 38, С. 1 - 30

Опубликована: Апрель 23, 2024

Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.

Язык: Английский

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Next-Generation Cardiac Interfacing Technologies Using Nanomaterial-Based Soft Bioelectronics

ACS Nano, Год журнала: 2024, Номер 18(19), С. 12025 - 12048

Опубликована: Май 6, 2024

Cardiac interfacing devices are essential components for the management of cardiovascular diseases, particularly in terms electrophysiological monitoring and implementation therapies. However, conventional cardiac typically composed rigid bulky materials thus pose significant challenges effective long-term with curvilinear surface a dynamically beating heart. In this regard, recent development intrinsically soft bioelectronic using nanocomposites, which fabricated by blending conductive nanofillers polymeric elastomeric matrices, has shown great promise. The bioelectronics not only endure dynamic motion heart maintain stable performance but also enable conformal, reliable, large-area target tissue, allowing high-quality mapping, feedback electrical stimulations, even mechanical assistance. Here, we explore next-generation strategies based on that utilize elastic nanocomposites. We first discuss used to manage diseases explain their undesired limitations. Then, introduce restraint utilizing materials. After discussion fabrication functionalization nanomaterials, introduction nanocomposites application therapy follow. Finally, comments future prospects technologies discussed.

Язык: Английский

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Fundamentals and Advances in Stimuli-Responsive Hydrogels and Their Applications: A Review

Gels, Год журнала: 2025, Номер 11(1), С. 30 - 30

Опубликована: Янв. 2, 2025

This review summarizes the fundamental concepts, recent advancements, and emerging trends in field of stimuli-responsive hydrogels. While numerous reviews exist on this topic, continues to evolve dynamically, certain research directions are often overlooked. To address this, we classify hydrogels based their response mechanisms provide an in-depth discussion key properties mechanisms, including swelling kinetics, mechanical properties, biocompatibility/biodegradability. We then explore hydrogel design, synthesis, structural engineering, followed by overview applications that relatively well established from a scientific perspective, biomedical uses (biosensing, drug delivery, wound healing, tissue engineering), environmental (heavy metal phosphate removal environment polluted water), soft robotics actuation. Additionally, highlight unconventional such as local micro-thermometers cell mechanotransduction. concludes with current challenges future prospects field, aiming inspire further innovations advancements bring them closer societal needs.

Язык: Английский

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Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 215 - 215

Опубликована: Фев. 7, 2025

Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability difficulties in ensuring patient adherence. These challenges have driven the development of advanced systems (DDS), with hydrogels especially nanogels emerging as promising materials overcome these limitations. Hydrogels, their biocompatibility, high water content, stimuli-responsive properties, provide controlled targeted release. This review explores evolution, classifications versus applications delivery, detailing synthesis methods, chemical crosslinking, physical self-assembly, techniques such microfluidics 3D printing. It also examines drug-loading mechanisms (e.g., encapsulation electrostatic interactions) release strategies diffusion, stimuli-responsive, enzyme-triggered). gels demonstrate significant advantages addressing limitations traditional DDS, offering improved stability, sustained release, specificity. Their adaptability extends various routes administration, topical, oral, injectable forms, while further enhance targeting through nanoscale precision stimuli responsiveness. Although transformative potential personalized medicine, remain scalable manufacturing, regulatory approval, delivery. Future include integrating biosensors for real-time monitoring, developing dual-stimuli-responsive systems, optimizing surface functionalization advancements aim establish cornerstones next-generation solutions, revolutionizing paving way innovative, patient-centered treatments.

Язык: Английский

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Design of oxide nanoparticles for biomedical applications

Nature Reviews Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Язык: Английский

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Drug-Loaded Lipid Magnetic Nanoparticles for Combined Local Hyperthermia and Chemotherapy against Glioblastoma Multiforme

ACS Nano, Год журнала: 2023, Номер 17(18), С. 18441 - 18455

Опубликована: Сен. 12, 2023

Glioblastoma multiforme (GBM) is a devastating tumor of the central nervous system, currently missing an effective treatment. The therapeutic gold standard consists surgical resection followed by chemotherapy (usually with temozolomide, TMZ) and/or radiotherapy. TMZ does not, however, provide significant survival benefit after completion treatment because development chemoresistance and heavy side effects systemic administration. Improvement conventional treatments complementary therapies are urgently needed to increase patient quality life. Stimuli-responsive lipid-based drug delivery systems offer promising prospects overcome limitations current treatments. In this work, multifunctional magnetic nanovectors functionalized peptide angiopep-2 loaded (Ang-TMZ-LMNVs) were tested enhance specific GBM therapy on in vivo model. Exposure alternating fields (AMFs) enabled hyperthermia be performed, that works synergy chemotherapeutic agent. Studies orthotopic human U-87 MG-Luc2 tumors nude mice have shown Ang-TMZ-LMNVs can accumulate remain local administration without crossing over into healthy tissue, effectively suppressing invasion proliferation significantly prolonging median time when combined AMF stimulation. This powerful synergistic approach has proven robust versatile nanoplatform for

Язык: Английский

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Micro/nanosystems for controllable drug delivery to the brain

The Innovation, Год журнала: 2023, Номер 5(1), С. 100548 - 100548

Опубликована: Ноя. 27, 2023

•Micro/nanosystems show their potential to address the challenges of precise drug delivery brain.•Microfluidic platforms enable creation biomimetic in vitro brain models.•Micro/nano materials is emerging as a key player controllable delivery.•The minimally invasive fiberbot microsystem reduces procedure's invasiveness.•Image tracking micro/nanosystems allows for controlled therapeutic interventions. Drug crucial treatment central nervous system disorders. While significant progress has been made recent years, there are still major achieving brain. Unmet clinical needs arise from various factors, including transport, handling large doses, methods crossing biological barriers, use imaging guidance, and effective models analyzing delivery. Recent advances have shown promise addressing some these challenges. These include utilization microfluidic test validate process setting, development novel micro/nanocarriers loads across blood-brain barrier, implementation micro-intervention systems delivering drugs through intraparenchymal or peripheral routes. In this article, we present review latest developments We also delve into relevant diseases, conventional methods. addition, discuss future prospects robotic equipped with directed transportation, real-time image closed-loop control.

Язык: Английский

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