The
initial
delivery
of
small-scale
magnetic
devices
such
as
microrobots
is
a
key,
but
often
overlooked,
aspect
for
their
use
in
clinical
applications.
deployment
these
within
the
dynamic
environment
human
body
presents
significant
challenges
due
to
dispersion
caused
by
circulatory
flows.
Here,
method
introduced
effectively
deliver
swarm
nanoparticles
fluidic
This
approach
integrates
magnetically
navigated
robotic
microcatheter
equipped
with
reservoir
storing
nanoparticles.
microfluidic
flow
facilitates
injection
into
fluid
stream,
and
field
gradient
guides
through
oscillatory
target
site.
are
engineered
enable
steering
To
demonstrate
this
approach,
experiments
conducted
utilizing
spinal
cord
phantom
simulating
intrathecal
catheter
applications
central
nervous
system.
These
results
that
proposed
successfully
concentrates
near
desired
location
precise
manipulation
gradients,
offering
promising
solution
controlled
untethered
micro-/nanodevices
complex
physiological
systems
body.
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Апрель 3, 2024
Abstract
Glioblastoma
(GBM)
is
the
most
aggressive
and
prevalent
primary
malignant
tumor
of
central
nervous
system.
Traditional
chemotherapy
has
poor
therapeutic
effects
significant
side
due
to
drug
resistance,
natural
blood‐brain
barrier
(BBB),
nonspecific
distribution,
leading
a
lack
clinically
effective
drugs.
Here,
1430
small
molecule
compounds
are
screened
based
on
high‐throughput
screening
platform
novel
anti‐GBM
drug,
lomitapide
(LMP)
obtained.
Furthermore,
bionic
nanodrug
delivery
system
(RFA
NPs)
actively
targeting
GBM
constructed,
which
mainly
consists
tetrahedral
DNA
nanocages
(tFNA
loaded
with
LMP
as
core
folate‐modified
erythrocyte–cancer
cell–macrophage
hybrid
membrane
(FRUR)
shell.
FRUR
camouflage
conferred
unique
features
tFNA
NPs,
including
excellent
biocompatibility,
improved
pharmacokinetic
profile,
efficient
BBB
permeability,
ability.
The
results
show
that
RFA
NPs
exhibited
superior
specific
activities,
reduced
off‐target
delivery,
prolonged
lifespan,
negligible
in
tumor‐bearing
mice.
This
study
combines
biomimetic
technology
provide
theoretical
practical
basis
for
development
optimization
clinical
treatment
strategies
treatment.
ACS Nano,
Год журнала:
2024,
Номер
18(26), С. 16359 - 16394
Опубликована: Июнь 11, 2024
Glioblastoma
(GBM)
remains
the
epitome
of
aggressiveness
and
lethality
in
spectrum
brain
tumors,
primarily
due
to
blood–brain
barrier
(BBB)
that
hinders
effective
treatment
delivery,
tumor
heterogeneity,
presence
treatment-resistant
stem
cells
contribute
recurrence.
Nanoparticles
(NPs)
have
been
used
overcome
these
obstacles
by
attaching
targeting
ligands
enhance
therapeutic
efficacy.
Among
ligands,
peptides
stand
out
their
ease
synthesis
high
selectivity.
This
article
aims
review
single
multiligand
strategies
critically.
In
addition,
it
highlights
other
integrate
effects
external
stimuli,
biomimetic
approaches,
chemical
approaches
as
nanocatalytic
medicine,
revealing
significant
potential
treating
GBM
with
peptide-functionalized
NPs.
Alternative
routes
parenteral
administration,
specifically
nose-to-brain
delivery
local
within
resected
cavity,
are
also
discussed.
Finally,
an
overview
them
discussed
provide
a
perspective
on
this
promising
field
therapy.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
Results in Engineering,
Год журнала:
2024,
Номер
23, С. 102473 - 102473
Опубликована: Июнь 28, 2024
This
study
investigated
the
use
of
magnetic
fluid
hyperthermia
(MFH)
for
treating
glioblastoma
multiforme
(GBM),
a
deadly
and
treatment-resistant
tumor.
It
considers
effects
nanoparticle
(MNP)
(different
sizes
materials),
alternating
field
(AMF)
characteristics
(frequency
strength
field),
MFH
duration,
injection
number,
using
realistic
brain
phantom,
considering
its
blood
circulation
system,
tumor,
healthy
tissue
properties.
Results
demonstrated
that
is
more
sensitive
to
frequency,
increasing
frequency
causing
greater
temperature
thermoablation
than
field.
The
can
be
increased
at
fixed
control
increase
in
mild
treatment
reliably.
size
MNP
significantly
impacts
when
exceeding
15.8
nm,
while
smaller
particles
do
not
affect
obtained.
Also,
tumor's
concentration
increases
uniformly
disperses
as
number
sites
increases.
examined
duration
(30–60
min),
it
important
optimize
prevent
irreparable
damage
cases
from
46
°C.
In
conclusion,
effectively
manage
generated
destruction
malignant
minimizing
tissue,
multiple
hyperthermia-related
parameters
must
adjusted
simultaneously.
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
14(12), С. 3494 - 3511
Опубликована: Май 13, 2024
Brain
drug
delivery
is
severely
hindered
by
the
presence
of
blood-brain
barrier
(BBB).
Its
functionality
relies
on
interactions
brain
endothelial
cells
with
additional
cellular
constituents,
including
pericytes,
astrocytes,
neurons,
or
microglia.
To
boost
delivery,
nanomedicines
have
been
designed
to
exploit
distinct
strategies,
magnetically
driven
nanocarriers
as
a
form
external
physical
targeting
BBB.
Herein,
lipid-based
magnetic
nanocarrier
prepared
low-energy
method
first
described.
Magnetic
nanocapsules
hydrodynamic
diameter
256.7
±
8.5
nm
(polydispersity
index:
0.089
0.034)
and
ξ-potential
-30.4
0.3
mV
were
obtained.
Transmission
electron
microscopy-energy
dispersive
X-ray
spectroscopy
analysis
revealed
efficient
encapsulation
iron
oxide
nanoparticles
within
oily
core
nanocapsules.
Both
thermogravimetric
phenanthroline-based
colorimetric
assay
showed
that
percentage
in
final
formulation
was
12
wt.%,
agreement
vibrating
sample
magnetometry
analysis,
specific
saturation
magnetization
12%
bare
nanoparticles.
non-toxic
range
50-300
μg/mL
over
72
h
against
both
human
cerebral
hCMEC/D3
Human
Vascular
Pericytes
cell
lines.
Interestingly,
higher
uptake
types
evidenced
an
field
than
absence
it
after
24
h.
This
increase
also
pericytes
only
3
Altogether,
these
results
highlight
potential
for
BBB
our
formulation.
Materials Advances,
Год журнала:
2024,
Номер
5(5), С. 2128 - 2139
Опубликована: Янв. 1, 2024
We
present
pH-sensitive
magnetic
nanofibers
for
thermo-chemotherapy.
This
approach
may
offer
a
versatile,
chemo-selective
method
targeted
drug
delivery
in
postsurgical
breast
cancer
treatment.
