An acoustically controlled helical microrobot

Science Advances, Год журнала: 2023, Номер 9(38)

Опубликована: Сен. 20, 2023

As a next-generation toolkit, microrobots can transform wide range of fields, including micromanufacturing, electronics, microfluidics, tissue engineering, and medicine. While still in their infancy, acoustically actuated are becoming increasingly attractive. However, the interaction acoustics with microstructure geometry is poorly understood, its study necessary for developing powered microrobots. We present an driven helical microrobot length 350 μm diameter 100 that capable locomotion using fin-like double-helix microstructure. This responds to sound stimuli at ~12 19 kHz mimics spiral motion natural microswimmers such as spirochetes. The asymmetric double helix interacts incident acoustic field, inducing propulsion torque causes rotate around long axis. Moreover, our has unique feature directionality being switchable by simply tuning frequency. demonstrate this 2D 3D artificial vasculatures single source.

Язык: Английский

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Metal organic framework-loaded biohybrid magnetic microrobots for enhanced antibacterial treatment

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 685, С. 133295 - 133295

Опубликована: Янв. 23, 2024

Язык: Английский

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Intelligent micro/nanomotors: Fabrication, propulsion, and biomedical applications

Nano Today, Год журнала: 2024, Номер 55, С. 102212 - 102212

Опубликована: Фев. 26, 2024

Язык: Английский

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Manipulation with sound and vibration: A review on the micromanipulation system based on sub-MHz acoustic waves

Ultrasonics Sonochemistry, Год журнала: 2023, Номер 96, С. 106441 - 106441

Опубликована: Май 15, 2023

Manipulation of micro-objects have been playing an essential role in biochemical analysis or clinical diagnostics. Among the diverse technologies for micromanipulation, acoustic methods show advantages good biocompatibility, wide tunability, a label-free and contactless manner. Thus, micromanipulations widely exploited micro-analysis systems. In this article, we reviewed micromanipulation systems that were actuated by sub-MHz waves. contrast to high-frequency range, microsystems operating at frequency are more accessible, whose sources low cost even available from daily devices (e.g. buzzers, speakers, piezoelectric plates). The broad availability, with addition make promising variety biomedical applications. Here, review recent progresses technologies, focusing on their applications fields. These based basic phenomenon, such as cavitation, radiation force, streaming. And categorized applications, introduce these mixing, pumping droplet generation, separation enrichment, patterning, rotation, propulsion actuation. hold great promise range enhancements biomedicines attract increasing interest further investigation.

Язык: Английский

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Dual‐Responsive Nanorobot‐Based Marsupial Robotic System for Intracranial Cross‐Scale Targeting Drug Delivery

Advanced Materials, Год журнала: 2023, Номер 36(9)

Опубликована: Окт. 30, 2023

Nanorobots capable of active movement are an exciting technology for targeted therapeutic intervention. However, the extensive motion range and hindrance blood-brain barrier impeded their clinical translation in glioblastoma therapy. Here, a marsupial robotic system constructed by integrating chemical/magnetic hybrid nanorobots (child robots) with miniature magnetic continuum robot (mother robot) intracranial cross-scale targeting drug delivery is reported. For primary on macroscale, enters cranial cavity through minimally invasive channel (e.g., Ommaya device) skull transports to pathogenic regions. Upon circumventing barrier, released perform secondary microscale further enhance spatial resolution delivery. In vitro experiments against cells derived from different patients conducted personalized treatment guidance. The operation feasibility within organisms shown ex vivo swine brain experiments. biosafety suggested Owing hierarchical method, rate, accuracy, efficacy have improved greatly. offers novel local strategy constitutes key milestone development platforms.

Язык: Английский

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Medical Microrobots

Annual Review of Biomedical Engineering, Год журнала: 2024, Номер 26(1), С. 561 - 591

Опубликована: Апрель 10, 2024

Scientists around the world have long aimed to produce miniature robots that can be controlled inside human body aid doctors in identifying and treating diseases. Such microrobots hold potential access hard-to-reach areas of through natural lumina. Wireless has overcome drawbacks systemic therapy, as well enable completely new minimally invasive procedures. The aim this review is fourfold: first, provide a collection valuable anatomical physiological information on target working environments together with engineering tools for design medical microrobots; second, comprehensive updated survey technological state art relevant classes third, analyze currently available tracking closed-loop control strategies compatible in-body environment; fourth, explore challenges still place, steer inspire future research.

Язык: Английский

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Chemical Micromotors Move Faster at Oil–Water Interfaces

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(6), С. 4221 - 4233

Опубликована: Фев. 2, 2024

Many real-world scenarios involve interfaces, particularly liquid–liquid that can fundamentally alter the dynamics of colloids. This is poorly understood for chemically active colloids release chemicals into their environment. We report here surprising discovery chemical micromotors─colloids convert fuels self-propulsion─move significantly faster at an oil–water interface than on a glass substrate. Typical speed increases ranged from 3 to 6 times up order magnitude and were observed different types motors interfaces made with oils. Such are likely caused by reactions glass–water interface, but exact mechanism remains unknown. Our results provide valuable insights complex interactions between micromotors environments, which important applications in human body or removal organic pollutants water. In addition, this study also suggests occur serve as probe such effect.

Язык: Английский

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Urease-Powered Black TiO₂ Micromotors for Photothermal Therapy of Bladder Cancer

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(3), С. 3019 - 3030

Опубликована: Янв. 13, 2024

Urease-powered nano/micromotors can move at physiological urea concentrations, making them useful for biomedical applications, such as treating bladder cancer. However, their movement in biological environments is still challenging. Herein, Janus micromotors based on black TiO2 with urease asymmetric catalytic coating were designed to take benefit of the optical properties under near-infrared light and capability simulated (urea). The microspheres half-coated a thin layer Au, l-Cysteine was utilized attach enzyme Au surface using its thiol group. Biocatalytic hydrolysis through biologically relevant concentrations provided driving force micromotors. A variety parameters, fuel concentration, viscosity, ionic character environment, used investigate how moved different water, PBS, NaCl, urine. results indicate that are propelled self-diffusiophoresis caused by enzymatic catalysis. Due low toxicity vitro anticancer effect, effective agents photothermal therapy, which help kill cancer cells. These promising suggest biocompatible hold great potential improving treatment facilitating diagnosis.

Язык: Английский

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External power-driven micro/nanorobots: Design, fabrication, and functionalization for tumor diagnosis and therapy

Progress in Materials Science, Год журнала: 2023, Номер 140, С. 101204 - 101204

Опубликована: Окт. 9, 2023

Язык: Английский

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Navigating micro- and nano-motors/swimmers with machine learning: Challenges and future directions

ChemPhysMater, Год журнала: 2024, Номер 3(3), С. 273 - 283

Опубликована: Июнь 20, 2024

Micro-/nano-motors (MNMs) or swimmers are minuscule machines that can convert various forms of energy, such as chemical, electrical, magnetic into motion. These devices have attracted significant attention owing to their potential application in a wide range fields drug delivery, sensing, and microfabrication. However, diverse shapes, sizes, structural/chemical compositions, the development MNMs faces several challenges, understanding structure-function relationships, which is crucial for achieving precise control over motion within complex environments. In recent years, machine learning techniques shown promise addressing these challenges improving performance MNMs. Machine analyze large amounts data, learn from patterns, make predictions, thereby enabling navigate environments, avoid obstacles, perform tasks with higher efficiency reliability. This review introduces current state-of-the-art MNM research, particular focus on employing understand manipulate navigation locomotion Finally, we discuss opportunities this field suggest future research directions.

Язык: Английский

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