Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 30, 2024
The
application
of
oncolytic
peptides
has
become
a
powerful
approach
to
induce
complete
and
long-lasting
remission
in
multiple
types
carcinomas,
as
affirmed
by
the
appearance
tumor-associated
antigens
adenosine
triphosphate
(ATP)
large
quantities,
which
jumpstarts
cancer-immunity
cycle.
However,
ATP
breakdown
product
is
significant
contributor
forming
immunosuppressive
tumor
microenvironment,
substantially
weakens
peptide-driven
immunotherapy.
In
this
study,
lipid-coated
micelle
(CA@TLM)
loaded
with
stapled
peptide
(PalAno)
an
2A
receptor
(A2AR)
inhibitor
(CPI-444)
devised
enact
tumor-targeted
immunotherapy
overcome
adenosine-mediated
immune
suppression
simultaneously.
CA@TLM
accumulates
tumors
high
efficiency,
acidic
microenvironment
prompts
rapid
release
PalAno
CPI-444.
Subsequently,
induces
swift
membrane
lysis
cells
antigenic
materials.
Meanwhile,
CPI-444
blocks
activation
adenosine-A2AR
signaling
pathway.
This
combined
exhibits
pronounced
synergy
at
stalling
growth
metastasis
animal
models
for
triple-negative
breast
cancer
melanoma,
providing
novel
strategy
enhanced
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(10), С. 12951 - 12964
Опубликована: Фев. 29, 2024
Combining
immune
checkpoint
blockade
(ICB)
therapy
with
chemotherapy
can
enhance
the
efficacy
of
ICB
and
expand
its
indications.
However,
limited
tumor
specificity
drugs
results
in
severe
adverse
reactions.
Additionally,
low
tissue
penetration
immune-related
events
associated
monoclonal
antibodies
restrict
their
widespread
application.
To
address
challenges
faced
by
traditional
combination
therapies,
we
design
a
dual-responsive
engineered
nanoparticle
based
on
ferritin
(denoted
as
CMFn@OXA),
achieving
tumor-targeted
delivery
controlled
release
anti-PD-L1
peptide
CLP002
oxaliplatin
(OXA).
Our
demonstrate
that
CMFn@OXA
not
only
exhibits
tumor-specific
accumulation
but
also
responds
to
matrix
metalloproteinase-2/9
(MMP-2/9),
facilitating
block
PD-1/PD-L1
interaction.
Simultaneously,
it
ensures
precise
OXA
cells
subsequent
within
acidic
environment
lysosomes,
thereby
fostering
synergistic
therapeutic
effect.
Compared
demonstrates
superior
performance
inhibiting
growth,
extending
survival
tumor-bearing
mice,
exhibiting
excellent
biocompatibility.
Collectively,
our
highlight
novel
promising
strategy
field
cancer
immunotherapy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Фев. 7, 2024
Cancer
nanovaccines
have
attracted
widespread
attention
by
inducing
potent
cytotoxic
T
cell
responses
to
improve
immune
checkpoint
blockade
(ICB)
therapy,
while
the
lack
of
co-stimulatory
molecules
limits
their
clinical
applications.
Here,
a
genetically
engineered
cancer
cytomembrane
nanovaccine
is
reported
that
simultaneously
overexpresses
molecule
CD40L
and
inhibitor
PD1
elicit
robust
antitumor
immunity
for
immunotherapy.
The
tumor
antigens
inherited
from
cytomembranes
effectively
stimulate
dendritic
(DC)-mediated
activation
cells,
on
significantly
blocks
PD1/PD-L1
signaling
pathway,
synergistically
stimulating
responses.
Benefiting
targeting
ability
cytomembranes,
this
formula
shows
an
enhanced
lymph
node
trafficking
retention.
Compared
with
original
induces
twofold
DC
maturation
satisfactory
precaution
efficacy
in
breast
mouse
model.
This
offers
simple,
safe,
strategy
incorporating
components
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(27)
Опубликована: Март 7, 2024
Abstract
Nucleic
acid
drugs
are
widely
used
in
biomedical
fields.
However,
one
of
the
main
challenges
vivo
is
to
selectively
deliver
nucleic
subcellular
compartments.
To
solve
this
problem,
an
oncolytic
virus‐like
nanoparticle,
OV@FN,
constructed
that
can
directly
acids
cytoplasm
through
membrane
fusion
response
slightly
acidic
environment
tumor.
OV@FN
composed
a
nano‐core
(NA‐Zn@G)
accurately
release
high
concentrations
glutathione
tumor
cells
and
hybrid
vesicle
(FN)
expressing
virus
glycoprotein
(mVSV‐G).
The
study
findings
suggest
efficiently
delivers
cells,
as
compared
normal
cells.
Importantly,
FN
effectively
induces
form
syncytium,
thus
promoting
intracellular
drug
diffusion,
enhancing
gene
therapy
effect.
In
silencing
test
shows
OV
siR
@FN
has
significant
delivery
performance.
melanoma
model,
3pdsR
remarkable
ablation
ability
improves
immunosuppressive
microenvironment
site.
offers
novel
approach
designing
platforms.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 30, 2024
The
application
of
oncolytic
peptides
has
become
a
powerful
approach
to
induce
complete
and
long-lasting
remission
in
multiple
types
carcinomas,
as
affirmed
by
the
appearance
tumor-associated
antigens
adenosine
triphosphate
(ATP)
large
quantities,
which
jumpstarts
cancer-immunity
cycle.
However,
ATP
breakdown
product
is
significant
contributor
forming
immunosuppressive
tumor
microenvironment,
substantially
weakens
peptide-driven
immunotherapy.
In
this
study,
lipid-coated
micelle
(CA@TLM)
loaded
with
stapled
peptide
(PalAno)
an
2A
receptor
(A2AR)
inhibitor
(CPI-444)
devised
enact
tumor-targeted
immunotherapy
overcome
adenosine-mediated
immune
suppression
simultaneously.
CA@TLM
accumulates
tumors
high
efficiency,
acidic
microenvironment
prompts
rapid
release
PalAno
CPI-444.
Subsequently,
induces
swift
membrane
lysis
cells
antigenic
materials.
Meanwhile,
CPI-444
blocks
activation
adenosine-A2AR
signaling
pathway.
This
combined
exhibits
pronounced
synergy
at
stalling
growth
metastasis
animal
models
for
triple-negative
breast
cancer
melanoma,
providing
novel
strategy
enhanced
