Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Ноя. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Язык: Английский

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Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(10), С. 849 - 868

Опубликована: Июль 18, 2024

Язык: Английский

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Manganese‐Based Immunomodulatory Nanocomposite with Catalase‐Like Activity and Microwave‐Enhanced ROS Elimination Ability for Efficient Rheumatoid Arthritis Therapy

Small, Год журнала: 2023, Номер 19(50)

Опубликована: Авг. 26, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease commonly associated with the accumulation of hyperactive immune cells (HICs), particularly macrophages pro-inflammatory (M1) phenotype, accompanied by elevated level reactive oxygen species (ROS), decreased pH and O2 content in joint synovium. In this work, an immunomodulatory nanosystem (IMN) developed for RA therapy modulating restoring function HICs inflamed tissues. Manganese tetraoxide nanoparticles (Mn3 O4 ) anchored on UiO-66-NH2 are designed, then hybrid coated Mn-EGCG film, further wrapped HA to obtain final nanocomposite @Mn3 /Mn-EGCG@HA (termed as UMnEH). When UMnEH diffuses inflammatory site synovium, stimulation microwave (MW) irradiation low trigger slow dissociation film. Then endogenously overexpressed hydrogen peroxide (H2 disintegrates exposed Mn3 NPs promote ROS scavenging generation. Assisted MW irradiation, microenvironment down-regulates expression hypoxia-inducible factor-1α (HIF-1α). Coupled clearance ROS, it promotes re-polarization M1 phenotype into anti-inflammatory (M2) macrophages. Therefore, multifunctional nanoplatform, IMN, exhibits promising potential modulate restore has exciting prospect treatment RA.

Язык: Английский

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Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis

Advanced Materials, Год журнала: 2024, Номер 36(48)

Опубликована: Окт. 6, 2024

Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, posing a serious public health problem. Here, advanced theranostic probe is introduced integrates activatable second near-infrared (NIR-II) fluorescence imaging for precise RA diagnosis with multi-pronged treatments. A novel molecular comprising long-wavelength aggregation-induced emission unit manganese carbonyl cage motif synthesized, which enables NIR-II activation concurrently releasing therapeutic carbon monoxide (CO) gas in inflamed microenvironment. This self-assembles into biocompatible nanoprobe, subsequently conjugated anti-IL-6R antibody to afford active-targeting ability of RA. The nanoprobe exhibits significant turn-on signal at lesion, enabling highly sensitive real-time monitoring. combination ROS scavenging, on-demand CO release, IL-6 signaling blockade results potent effect synergistic immunomodulation impact, significantly alleviating symptoms preventing destruction. research introduces paradigm development high-performance, strategies facilitate detection enhanced treatment RA-related diseases.

Язык: Английский

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Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Theranostics, Год журнала: 2024, Номер 14(6), С. 2490 - 2525

Опубликована: Янв. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Язык: Английский

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Graphene oxide quantum dots-loaded sinomenine hydrochloride nanocomplexes for effective treatment of rheumatoid arthritis via inducing macrophage repolarization and arresting abnormal proliferation of fibroblast-like synoviocytes

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 1, 2024

The characteristic features of the rheumatoid arthritis (RA) microenvironment are synovial inflammation and hyperplasia. Therefore, there is a growing interest in developing suitable therapeutic strategy for RA that targets macrophages fibroblast-like synoviocytes (FLSs). In this study, we used graphene oxide quantum dots (GOQDs) loading anti-arthritic sinomenine hydrochloride (SIN). By combining with hyaluronic acid (HA)-inserted hybrid membrane (RFM), successfully constructed new nanodrug system named HA@RFM@GP@SIN NPs target therapy inflammatory articular lesions. Mechanistic studies showed nanomedicine was effective against by facilitating transition M1 to M2 inhibiting abnormal proliferation FLSs vitro. vivo potential investigation demonstrated its effects on macrophage polarization hyperplasia, ultimately preventing cartilage destruction bone erosion preclinical models adjuvant-induced collagen-induced rats. Metabolomics indicated were mainly associated regulation steroid hormone biosynthesis, ovarian steroidogenesis, tryptophan metabolism, tyrosine metabolism. More notably, transcriptomic analyses revealed suppressed cell cycle pathway while inducing apoptosis pathway. Furthermore, protein validation disrupted excessive growth RAFLS interfering PI3K/Akt/SGK/FoxO signaling cascade, resulting decline cyclin B1 expression arrest G2 phase. Additionally, considering favorable biocompatibility biosafety, these multifunctional nanoparticles offer promising approach patients RA.

Язык: Английский

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Nanotechnology-empowered combination therapy for rheumatoid arthritis: principles, strategies, and challenges

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 22, 2024

Abstract Rheumatoid arthritis (RA) is an autoimmune disease with multifactorial etiology and intricate pathogenesis. In RA, repeated monotherapy frequently associated inadequate efficacy, drug resistance, severe side effects. Therefore, a shift has occurred in clinical practice toward combination therapy. However, conventional therapy encounters several hindrances, including low selectivity to arthritic joints, short half-lives, varying pharmacokinetics among coupled drugs. Emerging nanotechnology offers incomparable opportunity for developing advanced against RA. First, it allows co-delivering multiple drugs augmented physicochemical properties, targeted delivery capabilities, controlled release profiles. Second, enables therapeutic nanomaterials development, thereby expanding regimens include multifunctional nanomedicines. Lastly, facilitates the construction of all-in-one nanoplatforms assembled modalities, such as phototherapy, sonodynamic therapy, imaging. Thus, promising solution current bottleneck both RA treatment diagnosis. This review summarizes rationale, advantages, recent advances nano-empowered It also discusses safety considerations, drug–drug interactions, potential translation. Additionally, provides design tips outlook on future developments The objective this achieve comprehensive understanding mechanisms underlying unlock maximum nanotechnology, facilitating smooth transition research findings from laboratory practice.

Язык: Английский

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Mitochondrial-Targeted Ratiometric Near-Infrared Fluorescence Probe for Monitoring Nitric Oxide in Rheumatoid Arthritis

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(5), С. 4026 - 4035

Опубликована: Фев. 15, 2024

Rheumatoid arthritis (RA) is a destructive autoimmune disease, where nitric oxide (NO) closely implicated in the inflammatory processes of RA. Therefore, direct visualization NO essential to assess pathological changes Herein, mitochondrial-targeted near-infrared ratiometric fluorescent probe (NFL-NH2), based on intramolecular charge transfer effect, was synthesized and applied monitor content early Specially, NFL-NH2 showed 44-fold intensity ratio (I705/I780) response toward with detection limit 0.536 nM, enabling qualitative quantitative analysis NO. Additionally, can accurately target mitochondria sensitively detect exogenous endogenous RAW 264.7 cells. Notably, vivo RA monitoring assays demonstrated that rapidly levels associated damage degree mice models by fluorescence imaging. These results validate holds significant potential for diagnosing NO-mediated diseases.

Язык: Английский

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Tailored Covalent Organic Framework Platform: From Multistimuli, Targeted Dual Drug Delivery by Architecturally Engineering to Enhance Photothermal Tumor Therapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28245 - 28262

Опубликована: Май 21, 2024

Engineering bulk covalent organic frameworks (COFs) to access specific morphological structures holds paramount significance in boosting their functions cancer treatment; nevertheless, scant effort has been dedicated exploring this realm. Herein, silica core–shell templates and multifunctional COF-based reticulated hollow nanospheres (HCOFs) are novelly designed as a versatile nanoplatform investigate the simultaneous effect of dual-drug chemotherapy photothermal ablation. Taking advantage distinct structural properties template, resulting two-dimensional (2D) HCOF, featuring large internal voids peripheral interconnected mesoporous shell, presents intriguing benefits over its counterparts for treatment, including well-defined morphology, an outstanding drug loading capability (99.6%) attributed ultrahigh surface area (2087 m2/g), great crystallinity, improved tumor accumulation, adjustable release profile. After being loaded with hydrophilic doxorubicin remarkable capacity, obtained drug-loaded HCOFs were coated gold nanoparticles (Au NPs) confer them three properties, pore entrance blockage, active-targeting capability, biocompatibility via secondary modification, besides high near infrared (NIR) absorption efficient hyperthermia suppression. The resultant structure was functionalized mono-6-thio-β-cyclodextrin (β-CD) second pocket load docetaxel hydrophobic anticancer agent (combination index = 0.33). dual-drug-loaded HCOF displayed both pH- near-infrared-responsive on-demand release. In vitro vivo evaluations unveiled prominent synergistic performance coloaded elimination upon NIR light irradiation. This work opens up new avenue exciting applications structurally engineered hydrophobic/hydrophilic carriers well multimodal treatment agents.

Язык: Английский

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