ACS Nano,
Год журнала:
2024,
Номер
18(51), С. 34884 - 34901
Опубликована: Дек. 11, 2024
Periodontitis
is
characterized
by
dysbiotic
biofilms,
gingival
inflammation,
and
bone
resorption,
highlighting
the
urgent
need
for
a
comprehensive
approach
to
drug
combination
therapy.
In
this
study,
we
introduce
dynamic
covalent
nanonetworks
(dcNNWs)
synthesized
through
one-pot,
four-component
reaction-induced
self-assembly
method
using
polyamines,
2-formylphenylboronic
acid,
epigallocatechin
gallate,
alendronate.
The
formation
of
iminoboronate
bonds
drives
creation
dcNNWs,
allowing
controlled
release
in
periodontitis
microenvironment.
inclusion
catechol
bisphosphonate
imparts
exceptional
bioadhesive
properties
enhancing
their
efficacy
preventing
pathogenic
bacterial
biofilm
eliminating
mature
biofilms.
Moreover,
dcNNWs
efficiently
absorb
pathogen-associated
molecular
patterns
scavenge
excess
reactive
oxygen
species,
regulating
local
immune
response
demonstrating
anti-inflammatory
effects.
Additionally,
released
polyphenol
alendronate
from
alleviated
inflammation
enhanced
osteogenesis
significantly.
detailed
synergistic
effects
eradication,
anti-inflammation,
remodeling,
with
minimal
impact
on
healthy
tissues,
are
confirmed
rat
model
periodontitis.
With
facile
synthesis
process,
excellent
treatment,
biocompatibility,
our
present
promising
translational
solution
effective
management
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(3)
Опубликована: Ноя. 1, 2023
Abstract
Antimicrobial‐resistant
bacterial
infections
threaten
to
become
the
number
one
cause
of
death
by
year
2050.
Since
speed
at
which
antimicrobial‐resistance
develops
is
exceeding
pace
new
antimicrobials
come
market,
this
threat
cannot
be
countered
making
more,
and
stronger
antimicrobials.
Promising
should
not
only
kill
antimicrobial‐resistant
bacteria,
but
also
prevent
development
resistance
mechanisms
in
strains
still
susceptible.
Here,
PAMAM‐dendrimers
are
clustered
using
glutaraldehyde
form
megamers
that
core‐loaded
with
ciprofloxacin
functionalized
HA‐SNO.
Megamers
enzymatically
disintegrated
an
acidic
pH,
as
infectious
biofilms,
yielding
release
NO‐generation
does
contribute
killing
planktonic
Gram‐positive
Staphylococcus
aureus
Gram‐negative
Pseudomonas
aeruginosa
,
a
biofilm‐mode
growth
short‐lived
NO‐assisted
both
ciprofloxacin‐susceptible
ciprofloxacin‐resistant
released.
Repeated
sub‐culturing
bacteria
presence
ciprofloxacin‐loaded
HA‐SNO
PAMAM‐megamers
result
variants
repeated
culturing
ciprofloxacin.
Healing
wounds
infected
S.
variant
treated
ciprofloxacin‐loaded,
proceed
faster
through
infecting
stimulation
angiogenesis.
Biotechnology Journal,
Год журнала:
2024,
Номер
19(2)
Опубликована: Фев. 1, 2024
Biofilms
of
the
foodborne
pathogen
Staphylococcus
aureus
show
improved
resistance
to
antibiotics
and
are
difficult
eliminate.
To
enhance
antibacteria
biofilm
dispersion
via
extracellular
matrix
diffusion,
a
new
lipid
nanoparticle
was
prepared,
which
employed
mixture
phospholipids
0.8%
surfactin
shell.
In
nanoparticle,
31.56
μg
mL
ACS Materials Letters,
Год журнала:
2024,
Номер
6(7), С. 2582 - 2590
Опубликована: Май 28, 2024
Nanodrugs
composed
of
pure
pharmacologically
active
molecules
have
been
extensively
researched
as
emerging
nanomedicines
for
cancer
treatment.
However,
traditional
preparation
approaches
are
generally
limited
by
low
production
rates,
complicated
processes,
and
high
costs.
Here,
we
presented
a
simple
strategy
constructing
drug-based
nanoparticles
(2′F-ASO/CPT
NPs)
consisting
therapeutic
utilizing
2′-fluoro-substituted
antisense
oligonucleotide
(2′F-ASO)-mediated
self-assembly
with
the
anticancer
agent
camptothecin
(CPT).
The
2′F-substitution
could
enhance
intermolecular
interactions
between
DNA
CPT
through
electrostatic
dispersion
interactions.
resulting
2′F-ASO/CPT
NPs
had
drug
loading
capacity
improved
stability.
specifically
respond
to
P-glycoprotein
(P-gp)
mRNA
inhibit
expression
P-gp,
protecting
from
P-gp-mediated
efflux.
Therefore,
synergistic
effect
caused
be
successfully
achieved.
This
work
new
2′F-ASO-mediated
carrier-free
chemotherapy–gene
therapy
potential
treatment
efficacy.
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(45), С. 10778 - 10792
Опубликована: Янв. 1, 2023
Bacterial
sepsis
is
a
life-threatening
condition
caused
by
bacteria
entering
the
bloodstream
and
triggering
an
immune
response,
underscoring
importance
of
early
recognition
prompt
treatment.
Nanomedicine
holds
promise
for
addressing
through
improved
diagnostics,
nanoparticle
biosensors
detection
imaging,
enhanced
antibiotic
delivery,
combating
resistance,
modulation.
However,
challenges
remain
in
ensuring
safety,
regulatory
compliance,
scalability,
cost-effectiveness
before
clinical
implementation.
Further
research
needed
to
optimize
design,
efficacy,
strategies
effective
utilization
nanomedicines
bacterial
diagnosis
This
review
highlights
significant
potential
nanomedicines,
including
drug
immunomodulation
sepsis.
It
also
emphasizes
need
further
safety
profiles,
address
facilitate
translation.
ACS Nano,
Год журнала:
2024,
Номер
18(51), С. 34884 - 34901
Опубликована: Дек. 11, 2024
Periodontitis
is
characterized
by
dysbiotic
biofilms,
gingival
inflammation,
and
bone
resorption,
highlighting
the
urgent
need
for
a
comprehensive
approach
to
drug
combination
therapy.
In
this
study,
we
introduce
dynamic
covalent
nanonetworks
(dcNNWs)
synthesized
through
one-pot,
four-component
reaction-induced
self-assembly
method
using
polyamines,
2-formylphenylboronic
acid,
epigallocatechin
gallate,
alendronate.
The
formation
of
iminoboronate
bonds
drives
creation
dcNNWs,
allowing
controlled
release
in
periodontitis
microenvironment.
inclusion
catechol
bisphosphonate
imparts
exceptional
bioadhesive
properties
enhancing
their
efficacy
preventing
pathogenic
bacterial
biofilm
eliminating
mature
biofilms.
Moreover,
dcNNWs
efficiently
absorb
pathogen-associated
molecular
patterns
scavenge
excess
reactive
oxygen
species,
regulating
local
immune
response
demonstrating
anti-inflammatory
effects.
Additionally,
released
polyphenol
alendronate
from
alleviated
inflammation
enhanced
osteogenesis
significantly.
detailed
synergistic
effects
eradication,
anti-inflammation,
remodeling,
with
minimal
impact
on
healthy
tissues,
are
confirmed
rat
model
periodontitis.
With
facile
synthesis
process,
excellent
treatment,
biocompatibility,
our
present
promising
translational
solution
effective
management
