Contemporary
challenges
in
chemotherapy
for
triple
negative
breast
cancer
(TNBC)
are
inadequate
specificity
towards
malignant
cells,
constraints
imposed
by
dose-related
toxicities,
and
side
effects
on
normal
cells.
To
address
these
bottlenecks,
our
study
introduces,
a
drug-free
“trojan
horse-like”
folate
functionalized,
L-arginine-coated
ceria
(FA-L-arg-CeO2)
nanoplatform
treating
metastatic
TNBC.
We
show
that
this
engineered
nanozyme
exhibiting
enhanced
surface
oxygen
vacancies
(VO●)
facilitated
band
structure
reconstruction
amplified
the
photothermal/photodynamic
therapeutic
(PTT/PDT)
efficacy
under
single
laser
irradiation
(808
nm)
through
reactive
species
(ROS)
production,
thereby
outperforming
defect-free
commercial
nano-CeO2
rapid
tumour
ablation
(86%
48
h).
This
low-cost
targeted
therapy
substantial
receptor-mediated
endocytosis
accumulation
of
biostable
nanozymes
MDA-MB-231
cells
(84%
These
VO●-rich
FA-L-arg-CeO2
nanostructures
were
found
to
exhibit
distinctive
pH-active
multi-enzyme
mimicking
characteristics,
imparting
exceptional
potential
effectively
inhibited
cell
metastasis
(62%
within
12
Mechanistically,
we
observed
electrons
generated
at
during
modulate
pH-responsive
intracellular
redox
balance,
synergistically
killing
safeguarding
benign
L929
Unlike
drug-loaded
CeO2-based
nanoplatforms,
protected
healthy
from
radiation
damage
photo-triggered-ROS
scavenging
catalase.
novel,
nanozyme-based
leads
way
smart,
bio-inspired
multi-modal
treatments,
ensuring
bio-safety.
Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
Ferroptosis,
as
novel
type
of
regulated
cell
death
that
has
garnered
widespread
attention
over
the
past
decade,
witnessed
continuous
discovery
an
increasing
number
regulatory
mechanisms.
Trace
metal
elements
play
a
multifaceted
and
crucial
role
in
oncology.
Interestingly,
it
been
increasingly
evident
these
elements,
such
copper,
are
involved
regulation
iron
accumulation,
lipid
peroxidation
antiferroptotic
systems,
suggesting
existence
“nonferrous”
mechanisms
ferroptosis.
In
this
review,
comprehensive
overview
composition
mechanism
ferroptosis
is
provided.
The
interaction
between
copper
metabolism
(including
cuproptosis)
cancer,
well
roles
other
trace
(such
zinc,
manganese,
cobalt,
molybdenum)
specifically
focused.
Furthermore,
applications
nanomaterials
based
on
metals
cancer
therapy
also
reviewed
potential
strategies
for
co‐targeting
cuproptosis
explored.
Nevertheless,
light
intricate
ambiguous
nature
interactions,
ongoing
research
essential
to
further
elucidate
ferroptosis,
thereby
facilitating
development
therapeutic
targets
approaches
treatment.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Lung
cancer
has
high
metastasis
and
drug
resistance.
The
prognosis
of
lung
patients
is
poor
the
patients’
survival
chances
are
easily
neglected.
Ferroptosis
a
programmed
cell
death
proposed
in
2012,
which
differs
from
apoptosis,
necrosis
autophagy.
novel
type
regulated
driven
by
iron-dependent
lipid
peroxidation
subsequent
plasma
membrane
ruptures.
It
broad
prospects
field
tumor
disease
treatment.
At
present,
multiple
studies
have
shown
that
biological
compounds
can
induce
ferroptosis
cells,
exhibits
significant
anti-cancer
effects,
they
advantages
safety,
minimal
side
less
possibility
to
In
this
review,
we
summarize
used
for
treatment
focusing
on
its
mechanism.
addition,
systematically
review
current
research
status
combining
nanotechnology
with
treatment,
shed
new
light
targeting
pathways
applying
compounds-based
therapies.
Contemporary
challenges
in
chemotherapy
for
triple
negative
breast
cancer
(TNBC)
are
inadequate
specificity
towards
malignant
cells,
constraints
imposed
by
dose-related
toxicities,
and
side
effects
on
normal
cells.
To
address
these
bottlenecks,
our
study
introduces,
a
drug-free
“trojan
horse-like”
folate
functionalized,
L-arginine-coated
ceria
(FA-L-arg-CeO2)
nanoplatform
treating
metastatic
TNBC.
We
show
that
this
engineered
nanozyme
exhibiting
enhanced
surface
oxygen
vacancies
(VO●)
facilitated
band
structure
reconstruction
amplified
the
photothermal/photodynamic
therapeutic
(PTT/PDT)
efficacy
under
single
laser
irradiation
(808
nm)
through
reactive
species
(ROS)
production,
thereby
outperforming
defect-free
commercial
nano-CeO2
rapid
tumour
ablation
(86%
48
h).
This
low-cost
targeted
therapy
substantial
receptor-mediated
endocytosis
accumulation
of
biostable
nanozymes
MDA-MB-231
cells
(84%
These
VO●-rich
FA-L-arg-CeO2
nanostructures
were
found
to
exhibit
distinctive
pH-active
multi-enzyme
mimicking
characteristics,
imparting
exceptional
potential
effectively
inhibited
cell
metastasis
(62%
within
12
Mechanistically,
we
observed
electrons
generated
at
during
modulate
pH-responsive
intracellular
redox
balance,
synergistically
killing
safeguarding
benign
L929
Unlike
drug-loaded
CeO2-based
nanoplatforms,
protected
healthy
from
radiation
damage
photo-triggered-ROS
scavenging
catalase.
novel,
nanozyme-based
leads
way
smart,
bio-inspired
multi-modal
treatments,
ensuring
bio-safety.
