Gels,
Год журнала:
2024,
Номер
10(3), С. 162 - 162
Опубликована: Фев. 21, 2024
Extracellular
vesicles
(EVs),
especially
exosomes,
have
shown
great
therapeutic
potential
in
the
treatment
of
diseases,
as
they
can
target
cells
or
tissues.
However,
effect
EVs
is
limited
due
to
susceptibility
immune
system
clearance
during
transport
vivo.
Hydrogels
become
an
ideal
delivery
platform
for
their
good
biocompatibility
and
porous
structure.
This
article
reviews
preparation
application
EVs-loaded
hydrogels
a
cell-free
therapy
strategy
diseases.
The
also
discusses
challenges
future
outlook
hydrogels.
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Дек. 7, 2023
Low
back
pain
caused
by
disc
herniation
and
spinal
stenosis
imposes
an
enormous
medical
burden
on
society
due
to
its
high
prevalence
refractory
nature.
This
is
mainly
the
long-term
inflammation
degradation
of
extracellular
matrix
in
process
intervertebral
degeneration
(IVDD),
which
manifests
as
loss
water
nucleus
pulposus
(NP)
formation
fibrous
fissures.
Biomaterial
repair
strategies
involving
hydrogels
play
important
role
treatment
degeneration.
Excellent
biocompatibility,
tunable
mechanical
properties,
easy
modification,
injectability,
ability
encapsulate
drugs,
cells,
genes,
etc.
make
good
candidates
scaffolds
cell/drug
carriers
for
treating
NP
other
aspects
IVDD.
review
first
briefly
describes
anatomy,
pathology,
current
treatments
IVDD,
then
introduces
different
types
addresses
"smart
hydrogels".
Finally,
we
discuss
feasibility
prospects
using
treat
Pharmaceutics,
Год журнала:
2024,
Номер
16(8), С. 979 - 979
Опубликована: Июль 24, 2024
Intervertebral
disc
degeneration
(IVDD)
stands
as
the
foremost
contributor
to
low
back
pain
(LBP),
imposing
a
substantial
weight
on
world
economy.
Traditional
treatment
modalities
encompass
both
conservative
approaches
and
surgical
interventions;
however,
former
falls
short
in
halting
IVDD
progression,
while
latter
carries
inherent
risks.
Hence,
quest
for
an
efficacious
method
reverse
onset
is
paramount.
Biomaterial
delivery
systems,
exemplified
by
hydrogels,
microspheres,
microneedles,
renowned
their
exceptional
biocompatibility,
biodegradability,
biological
efficacy,
mechanical
attributes,
have
found
widespread
application
bone,
cartilage,
various
tissue
engineering
endeavors.
Consequently,
IVD
has
emerged
burgeoning
field
of
interest.
This
paper
succinctly
introduces
intervertebral
(IVD)
structure
pathophysiology
IVDD,
meticulously
classifies
biomaterials
repair,
reviews
recent
advances
field.
Particularly,
strengths
weaknesses
are
emphasized,
potential
avenues
future
research
suggested.
Journal of Orthopaedic Surgery and Research,
Год журнала:
2024,
Номер
19(1)
Опубликована: Дек. 5, 2024
Low
back
pain
caused
by
intervertebral
disc
degeneration
(IDD)
has
emerged
as
a
significant
global
public
health
concern,
with
far-reaching
consequences
for
patients'
quality
of
life
and
healthcare
systems.
Although
previous
research
have
revealed
that
the
mechanisms
cell
apoptosis,
pyroptosis
necroptosis
can
aggravate
IDD
damage
mediating
inflammation
promoting
extracellular
matrix
degradation,
but
they
cannot
explain
connection
between
different
death
ion
metabolism
disorders.
The
latest
study
shows
such
cellular
senescence,
ferroptosis,
cuproptosis,
PANopotosis
similar
roles
in
progression
degeneration,
not
exactly
same
mechanism.
This
paper
summarizes
effects
various
patterns
on
disease
IDD,
related
molecular
signaling
pathways,
providing
new
perspectives
potential
clinical
intervention
strategies
prevention
treatment
IDD.
Gels,
Год журнала:
2024,
Номер
10(3), С. 162 - 162
Опубликована: Фев. 21, 2024
Extracellular
vesicles
(EVs),
especially
exosomes,
have
shown
great
therapeutic
potential
in
the
treatment
of
diseases,
as
they
can
target
cells
or
tissues.
However,
effect
EVs
is
limited
due
to
susceptibility
immune
system
clearance
during
transport
vivo.
Hydrogels
become
an
ideal
delivery
platform
for
their
good
biocompatibility
and
porous
structure.
This
article
reviews
preparation
application
EVs-loaded
hydrogels
a
cell-free
therapy
strategy
diseases.
The
also
discusses
challenges
future
outlook
hydrogels.
