Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Янв. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Язык: Английский

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Engineered MXene Biomaterials for Regenerative Medicine

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Язык: Английский

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Regulation of T Cell Glycosylation by MXene/β‐TCP Nanocomposite for Enhanced Mandibular Bone Regeneration

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Immune-mediated bone regeneration driven by biomaterials offers a therapeutic strategy for repairing defects. Among 2D nanomaterials, Ti3C2Tx MXenes have garnered substantial attention their potential in tissue regeneration. This investigation concentrates on the role of MXene nanocomposites modulating immune microenvironment within defects to facilitate restoration. are synthetized, incorporated into beta-tricalcium phosphate ceramics (β-TCP) (T-MXene), and osteoinductive immunomodulatory effects evaluated. The T-MXene-treated T-cells marrow stromal cells (BMSCs) explored. In addition, its is assessed vivo using critical-sized mandibular defect model. underlying mechanisms which T-MXene regulates T-cell differentiation explored via whole-transcriptome RNA sequencing. scaffolds activate N-glycosylation T cells, possess anti-inflammatory antioxidant effects, thereby inducing pro-regenerative response. increased proportion IL-4+ among primary lymph nodes, ultimately promoting osteogenesis BMSCs injured mandibles. distinctive function MXene-based osteoimmunomodulation provides solid foundation further exploration application as response modulators, potentially advancing use regenerative medicine.

Язык: Английский

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Advances in conducting nanocomposite hydrogels for wearable biomonitoring

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Recent advancements in wearable biosensors and bioelectronics highlight biocompatible conducting nanocomposite hydrogels as key components for personalized health devices soft electronics.

Язык: Английский

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Hydrogels and hydrogel-based drug delivery systems for promoting refractory wound healing: Applications and prospects

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138098 - 138098

Опубликована: Ноя. 1, 2024

Язык: Английский

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Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Март 2, 2024

Abstract Surgical resection of bone tumors is the primary approach employed in treatment cancer. Simultaneously, perioperative interventions, particularly postoperative adjuvant anticancer strategies, play a crucial role achieving satisfactory therapeutic outcomes. However, occurrence tumor recurrence, metastasis, extensive defects, and infection are significant risks that can result unfavorable prognoses or even failure. In recent years, there has been progress development biomaterials, leading to emergence new options for therapy regeneration. This report aims comprehensively analyze strategic unique biomaterials with inherent healing properties bioactive capabilities tissue These composite classified into metallic, inorganic non‐metallic, organic types, thoroughly investigated their responses external stimuli such as light magnetic fields, internal interventions including chemotherapy catalytic therapy, combination well Additionally, an overview self‐healing materials osteogenesis provided potential applications combating osteosarcoma promoting formation explored. Furthermore, safety concerns integrated current limitations addressed, while also discussing challenges future prospects.

Язык: Английский

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Single‐Atom Cu Nanozyme‐Loaded Bone Scaffolds for Ferroptosis‐Synergized Mild Photothermal Therapy in Osteosarcoma Treatment

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(15)

Опубликована: Март 1, 2024

Abstract The rapid multiplication of residual tumor cells and poor reconstruction quality new bone are considered the major challenges in postoperative treatment osteosarcoma. It is a promising candidate for composite scaffold which combines photothermal therapy (PTT) regeneration induction local However, it inevitable to damage normal tissues around due hyperthermia PTT, while mild heat shows limited effect on antitumor as can be easily repaired by stress‐induced shock proteins (HSP). This study reports type single‐atom Cu nanozyme‐loaded scaffolds, exhibit exceptional conversion properties well peroxidase glutathione oxidase mimicking activities vitro experiments. leads lipid peroxidation (LPO) reactive oxygen species (ROS) upregulation, ultimately causing ferroptosis. accumulation LPO ROS also contributes HSP70 inactivation, maximizing PTT efficiency against tumors at an appropriate therapeutic temperature minimizing surrounding tissues. Further, promotes via continuous release bioactive ions (Ca 2+ , P 5+ Si 4+ ). results vivo experiments reveal that scaffolds inhibit growth promote repair.

Язык: Английский

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Enhanced interfacial interactions and enriched active sites in self-assembly amino-functionalized bacterial cellulose/MXene composite for wastewater treatment

Chemical Engineering Journal, Год журнала: 2024, Номер 488, С. 151078 - 151078

Опубликована: Апрель 7, 2024

Язык: Английский

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Endogenous electric field coupling Mxene sponge for diabetic wound management: haemostatic, antibacterial, and healing

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 2, 2024

Improper management of diabetic wound effusion and disruption the endogenous electric field can lead to passive healing damaged tissue, affecting process tissue cascade repair. This study developed an extracellular matrix sponge scaffold (K1P6@Mxene) by incorporating Mxene into acellular dermal stroma-hydroxypropyl chitosan interpenetrating network structure. is designed couple with promote precise remodelling in wounds. The fibrous structure closely resembles that a natural matrix, providing conducive microenvironment for cells adhere grow, exchange oxygen. Additionally, inclusion enhances antibacterial activity(98.89%) electrical conductivity within scaffold. Simultaneously, K1P6@Mxene exhibits excellent water absorption (39 times) porosity (91%). It actively interacts guide cell migration growth on surface upon absorbing exudate. In vivo experiments, reduced inflammatory response wounds, increased collagen deposition arrangement, promoted microvascular regeneration, Facilitate expedited re-epithelialization minimize scar formation, accelerate wounds 7 days. Therefore, this scaffold, combined field, presents appealing approach comprehensive repair

Язык: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101553 - 101553

Опубликована: Фев. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Язык: Английский

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