Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Jan. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Language: Английский

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Regulation of T Cell Glycosylation by MXene/β‐TCP Nanocomposite for Enhanced Mandibular Bone Regeneration

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Immune-mediated bone regeneration driven by biomaterials offers a therapeutic strategy for repairing defects. Among 2D nanomaterials, Ti3C2Tx MXenes have garnered substantial attention their potential in tissue regeneration. This investigation concentrates on the role of MXene nanocomposites modulating immune microenvironment within defects to facilitate restoration. are synthetized, incorporated into beta-tricalcium phosphate ceramics (β-TCP) (T-MXene), and osteoinductive immunomodulatory effects evaluated. The T-MXene-treated T-cells marrow stromal cells (BMSCs) explored. In addition, its is assessed vivo using critical-sized mandibular defect model. underlying mechanisms which T-MXene regulates T-cell differentiation explored via whole-transcriptome RNA sequencing. scaffolds activate N-glycosylation T cells, possess anti-inflammatory antioxidant effects, thereby inducing pro-regenerative response. increased proportion IL-4+ among primary lymph nodes, ultimately promoting osteogenesis BMSCs injured mandibles. distinctive function MXene-based osteoimmunomodulation provides solid foundation further exploration application as response modulators, potentially advancing use regenerative medicine.

Language: Английский

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Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: March 2, 2024

Abstract Surgical resection of bone tumors is the primary approach employed in treatment cancer. Simultaneously, perioperative interventions, particularly postoperative adjuvant anticancer strategies, play a crucial role achieving satisfactory therapeutic outcomes. However, occurrence tumor recurrence, metastasis, extensive defects, and infection are significant risks that can result unfavorable prognoses or even failure. In recent years, there has been progress development biomaterials, leading to emergence new options for therapy regeneration. This report aims comprehensively analyze strategic unique biomaterials with inherent healing properties bioactive capabilities tissue These composite classified into metallic, inorganic non‐metallic, organic types, thoroughly investigated their responses external stimuli such as light magnetic fields, internal interventions including chemotherapy catalytic therapy, combination well Additionally, an overview self‐healing materials osteogenesis provided potential applications combating osteosarcoma promoting formation explored. Furthermore, safety concerns integrated current limitations addressed, while also discussing challenges future prospects.

Language: Английский

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Single‐Atom Cu Nanozyme‐Loaded Bone Scaffolds for Ferroptosis‐Synergized Mild Photothermal Therapy in Osteosarcoma Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(15)

Published: March 1, 2024

Abstract The rapid multiplication of residual tumor cells and poor reconstruction quality new bone are considered the major challenges in postoperative treatment osteosarcoma. It is a promising candidate for composite scaffold which combines photothermal therapy (PTT) regeneration induction local However, it inevitable to damage normal tissues around due hyperthermia PTT, while mild heat shows limited effect on antitumor as can be easily repaired by stress‐induced shock proteins (HSP). This study reports type single‐atom Cu nanozyme‐loaded scaffolds, exhibit exceptional conversion properties well peroxidase glutathione oxidase mimicking activities vitro experiments. leads lipid peroxidation (LPO) reactive oxygen species (ROS) upregulation, ultimately causing ferroptosis. accumulation LPO ROS also contributes HSP70 inactivation, maximizing PTT efficiency against tumors at an appropriate therapeutic temperature minimizing surrounding tissues. Further, promotes via continuous release bioactive ions (Ca 2+ , P 5+ Si 4+ ). results vivo experiments reveal that scaffolds inhibit growth promote repair.

Language: Английский

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Enhanced interfacial interactions and enriched active sites in self-assembly amino-functionalized bacterial cellulose/MXene composite for wastewater treatment

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 151078 - 151078

Published: April 7, 2024

Language: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

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Tissue‐Adhesive and Antibacterial Hydrogel Promotes MDR Bacteria‐Infected Diabetic Wound Healing via Disrupting Bacterial Biofilm, Scavenging ROS and Promoting Angiogenesis

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Effective treatment of diabetic wounds remains challenging because multidrug-resistant (MDR) bacterial infections, excessive oxidative stress, and impaired angiogenesis. In this study, a tissue-adhesive antibacterial hydrogel incorporating MXene deferoxamine (DFO)-loaded microspheres is developed for the MDR bacteria-infected wounds. The built based on covalent crosslinking between ε-poly(L-lysine) o-phthalaldehyde-terminated four-arm poly(ethylene glycol). exhibited excellent mechanical properties, tissue adhesion strength, biocompatibility, biodegradability. Under near-infrared (NIR) irradiation, converted light into heat elevated local temperature rapidly, enabling rapid disintegration biofilms. Simultaneously, exerted inherent activity, persistently killing planktonic bacteria, effectively controlling wound infections. encapsulated DFO then released from in sustained controlled manner, promoted angiogenesis during healing. Additionally, MXenes can scavenge reactive oxygen species alleviate inflammation. methicillin-resistant Staphylococcus aureus-infected model mice, composite along with NIR irradiation efficiently reduced infectious accelerated healing by promoting alleviating This has great clinical potential wounds, particularly environments involving motion infection.

Language: Английский

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Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated still poses significant challenges due lack concerns innervation. Design rationale multifunctional biomaterials both tissue-induction and neural induction activities shows great potential regeneration. Recently, research application inorganic attracts increasing attention in innervated multi-tissue such as central nerves, bone, skin, because its superior tunable chemical composition, topographical structures, physiochemical properties. More importantly, easily combined other organic materials, biological factors, external stimuli enhance their effects. This review presents a comprehensive overview recent advancements It begins introducing classification properties typical design inorganic-based material composites. Then, progresses regenerating various nerves nerve-innervated systematically reviewed. Finally, existing future perspectives proposed. may pave way direction offers new strategy regeneration combination

Language: Английский

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Controlled-Release of Cinnamaldehyde from MXene/ZIF8/Gelatin Composite Coatings: An Integrated Strategy to Combat Implant-Associated Infection

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 251, P. 114615 - 114615

Published: March 7, 2025

Language: Английский

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Engineered MXene Biomaterials for Regenerative Medicine

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing

Language: Английский

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