ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(49), С. 67028 - 67044
Опубликована: Март 18, 2024
Bacterial
infection
and
insufficient
osteogenic
activity
are
the
main
causes
of
orthopedic
implant
failure.
Conventional
surface
modification
methods
difficult
to
meet
requirements
for
long-term
placement.
In
order
better
regulate
function
surfaces,
especially
improve
both
antibacterial
activity,
external
stimuli-responsive
(ESR)
strategies
have
been
employed
implants.
External
stimuli
act
as
"smart
switches"
interactions
with
bacteria
cells.
The
balance
between
capabilities
surfaces
can
be
achieved
through
these
specific
ESR
manifestations,
including
temperature
changes,
reactive
oxygen
species
production,
controlled
release
bioactive
molecules,
functional
ions,
etc.
This
Review
summarizes
recent
progress
on
different
(based
light,
ultrasound,
electric,
magnetic
fields)
that
effectively
performance
capability
Furthermore,
current
limitations
challenges
implants
well
future
development
direction
also
discussed.
Theranostics,
Год журнала:
2025,
Номер
15(8), С. 3490 - 3516
Опубликована: Фев. 24, 2025
Rationale:
Dental
implant
restoration
is
essential
for
rehabilitating
dentition
defects.
However,
peri-implantitis
(PI)
seriously
threatens
the
long-term
stability
of
implants.
Treating
PI
requires
complete
eradication
plaque
biofilm
and
meticulous
modulation
inflammatory
responses.
Antibacterial
photodynamic
therapy
(aPDT)
presents
a
promising
potential
in
antibacterial
realm.
Nonetheless,
traditional
aPDT
faces
challenges
such
as
inadequate
penetration
distribution
photosensitizers,
well
lack
precise
bacteria
targeting.
Moreover,
excessive
ROS
generated
by
will
aggravate
oxidative
stress
peri-implant
tissues,
this
issue
cannot
be
neglected.
Methods:
The
CuTA-Por@ε-PL
nanoplatforms
(CPP
NPs)
were
synthesized
characterized
using
dynamic
light
scattering,
transmission
electron
microscopy,
dye
probes
detail.
anti-inflammatory
activities
CPP
NPs
evaluated
both
vitro
vivo.
vivo
therapeutic
efficacy
was
successively
analyzed
through
micro-CT,
hematoxylin
eosin
staining,
Masson's
immunofluorescence
colony
formation
units
(CFU),
among
other
techniques.
Results:
Porphyrin
(Por),
CuTA
nanozyme
with
SOD/CAT
activities,
ε-Polylysine
(ε-PL)
combined
to
fabricate
via
straightforward
approach.
notable
positive
charge
facilitated
penetration,
Then,
irradiation
660
nm
laser
triggered
burst
elimination.
After
aPDT,
scavenged
residual
modulated
host
immunity
regulating
macrophage
polarization.
As
result,
CPP-treated
groups
demonstrated
most
outstanding
performance
rat
model.
Conclusions:
Given
pathogenesis
PI,
strategy
rationally
designed
multifunctional
NP
functions
spatiotemporal
regulation.
It
provides
potentially
novel
approach
treatment,
which
may
have
profound
impact
on
improving
prognosis
patients
advancing
field
dentistry.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(49), С. 67028 - 67044
Опубликована: Март 18, 2024
Bacterial
infection
and
insufficient
osteogenic
activity
are
the
main
causes
of
orthopedic
implant
failure.
Conventional
surface
modification
methods
difficult
to
meet
requirements
for
long-term
placement.
In
order
better
regulate
function
surfaces,
especially
improve
both
antibacterial
activity,
external
stimuli-responsive
(ESR)
strategies
have
been
employed
implants.
External
stimuli
act
as
"smart
switches"
interactions
with
bacteria
cells.
The
balance
between
capabilities
surfaces
can
be
achieved
through
these
specific
ESR
manifestations,
including
temperature
changes,
reactive
oxygen
species
production,
controlled
release
bioactive
molecules,
functional
ions,
etc.
This
Review
summarizes
recent
progress
on
different
(based
light,
ultrasound,
electric,
magnetic
fields)
that
effectively
performance
capability
Furthermore,
current
limitations
challenges
implants
well
future
development
direction
also
discussed.
