The Science of The Total Environment, Год журнала: 2024, Номер 957, С. 177582 - 177582
Опубликована: Ноя. 27, 2024
Язык: Английский
International Journal of Hydrogen Energy, Год журнала: 2024, Номер 82, С. 724 - 732
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
8
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Май 9, 2024
Abstract Radiotherapy-induced immune activation holds great promise for optimizing cancer treatment efficacy. Here, we describe a clinically used radiosensitizer hafnium oxide (HfO 2 ) that was core coated with MnO shell followed by glucose oxidase (GOx) doping nanoplatform @MnO @GOx, HMG) to trigger ferroptosis adjuvant effects glutathione depletion and reactive oxygen species production. This cascade potentiation further sensitized radiotherapy enhancing DNA damage in 4T1 breast tumor cells. The combination of HMG nanoparticles effectively activated the damaged Mn 2+ -mediated cGAS-STING pathway vitro vivo. process had significant inhibitory on progression initiating an anticancer systemic response prevent distant recurrence achieve long-lasting suppression both primary tumors. Furthermore, as-prepared “turned on” spectral computed tomography (CT)/magnetic resonance dual-modality imaging signals, demonstrated favorable contrast enhancement capabilities under GSH microenvironment. result highlighted potential as theranostic achieving molecular guided sensitization induced synergistic immunotherapy.
Язык: Английский
Процитировано
7
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(4)
Опубликована: Июль 1, 2024
Abstract Radiotherapy is an invaluable tool in the treatment of cancer. However, when used as a monotherapy, it fails to provide curative outcomes. Chemotherapy drugs are often included boost effects radiation. Key classes radiosensitizing include platinum compounds, anthracyclines, antimetabolites, taxanes, topoisomerase inhibitors, alkylating agents, and DNA damage repair inhibitors. Chemoradiotherapy suffers from not only systemic toxicities chemotherapy but also synergistic radiation toxicity well. It critical deliver molecules tumor cells while avoiding adjacent healthy tissues. Currently, nanomedicine provides avenue for specific delivery radiosensitizers. Nanoscale vehicles can be synthesized lipids, polymers, or inorganic materials. Additionally, encompasses stimuli responsive particles including prodrug formulation activation. Clinically, radiotherapy intertwined with approved DOXIL Abraxane. Though many challenges remain, ongoing progress evidences promising future both chemoradiotherapy. This article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Cardiovascular Emerging Technologies
Язык: Английский
Процитировано
4
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Bioimaging technology has been broadly used in biomedicine, and the growth of multimodal imaging based on synergistic advantages can overcome shortcomings traditional single-modal bioimaging methods attain high specificity sensitivity fields biosensing. The analysis low-abundance microRNAs (miRNAs) complex organisms is importance for early-stage diagnosis clinical treatment tumors. In our current study, a biosensing nanoplatform Tf-AuNCs MnO2 nanosheets was developed tumor cells. First, oxidizable provided smart tool use as nanocarriers contrast agents intracellular glutathione (GSH)-activated magnetic resonance (MRI). Then, delivered Tf-AuNC-based nanoplatforms into cells through endocytosis. Endogenous GSH degraded Mn2+, released functional nucleic acid probes perform specific responses to miR-21 exhibiting including two-photon near-infrared fluorescence (TP-NIRFI), lifetime (FLIM), MRI. Finally, achieved satisfactory results tissues by TP-NIRFI (300.0 μm penetration depth), FLIM (τ ≈ 50.0 ns), Therefore, show great potential detection
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract The complex composition of traditional Chinese medicines (TCMs) has posed challenges for in‐depth study and global application, despite their abundance bioactive compounds that make them valuable resources disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise This involves elucidating the structure‐activity relationships within compositions, ensuring accurate in vivo delivery, monitoring delivery process. review discusses research progress precision treatment from three perspectives: spatial multi‐omics technology therapeutic activity, carrier systems medical imaging visualizing aim establish a novel paradigm advances therapy TCMs.
Язык: Английский
Процитировано
0
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 1, 2025
ABSTRACT The clinical availability of photon‐counting computed tomography (PCCT) has ushered in a new era CT imaging. Spectral imaging coupled with superior contrast resolution, and ultrahigh spatial resolution (200 μm) offered by PCCT the potential to revolutionize value‐driven multicolor generated excitement, renewed interest, novel agent development for comprehensive disease interrogation, prediction monitoring treatment outcomes. Nanoparticles provide versatile powerful platform next generation agents spectral PCCT. In this article, we review recent developments use nanoparticle We also discuss future research translational opportunities nanoparticle‐based enabled advent describe key considerations their translation.
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2024, Номер 36(29)
Опубликована: Май 1, 2024
DNA double-strand breaks (DSBs) yield highly determines radiotherapy efficacy. However, improving the inherent radiosensitivity of tumor to promote radiation-induced DSBs remains a challenge. Using theoretical and experimental models, underexplored impact Z-DNA conformations on radiosensitivity, yielding higher than other conformations, is discovered. Thereout, radiosensitization strategy focused inducing conformation, utilizing CBL@HfO
Язык: Английский
Процитировано
3
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Окт. 7, 2024
Utilizing metal nanoprobes with unique K-edge identities to visualize complementary biological activities simultaneously can provide valuable information about complex processes. This study describes the design and preparation of an innovative pair demonstrates feasibility their simultaneous quantitative detection using spectral photon-counting computed tomography (SPCCT). Glycosaminoglycan (GAG) capped nanoparticles (ca. 15-20 nm) targeting two distinct components cartilage tissue, namely, aggrecan (acan) aggrecanase (acanase) are designed synthesized. These targeted comprised praseodymium (Pr) hafnium (Hf), well-separated energies, enable ratiometric imaging dual biomarkers in tissue. Following extensive physico-chemical characterization ligand-targeted particles, homing vitro is demonstrated. The material discrimination quantification these particles also achieved corroborated inductively coupled plasmon spectroscopy. For first time, use reported as a contrast agent for SPCCT ability it multicontrast diseases. Importantly, potential molecular tracking osteoarthritis (OA) progression shown based approach.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10386 - 10386
Опубликована: Сен. 26, 2024
Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) cells form essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, function. Understanding these mechanisms involves creating an appropriate support elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed mimic characteristics of ECM, thereby triggering responsive closely resemble those induced by a natural physiological system. The generated specific stimuli depend on different or synthetic origins polymers, chemical composition, assembly structure, physical surface properties biomaterials. This review discusses most widely used their customization develop with tailored properties. It examines how biomaterials-based be harnessed replicate functions biological cells, making them suitable biomedical biotechnological applications.
Язык: Английский
Процитировано
2
Materials Letters, Год журнала: 2024, Номер 373, С. 137141 - 137141
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
1