Springer proceedings in physics, Год журнала: 2025, Номер unknown, С. 285 - 288
Опубликована: Янв. 1, 2025
Язык: Английский
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Comorbid anxiety in chronic pain is clinically common, with a comorbidity rate of over 50%. The main treatments are based on pharmacological, interventional, and implantable approaches, which have limited efficacy carry risk side effects. Here, we report terahertz (THz, 10 12 Hz) wave stimulation (THS) technique, exerts nonthermal, long-term modulatory effects neuronal activity by reducing the binding between nano-sized glutamate molecules GluA2, leading to relief comorbid anxiety-like behaviors mice. In mice co-occurring induced complete Freund’s adjuvant (CFA) injection, hyperactivity was observed glutamatergic neurons anterior cingulate cortex (ACC Glu ). Using whole-cell recording ACC slices, demonstrated that THS (34 THz) effectively inhibited excitability . Moreover, molecular dynamics simulations showed reduced number hydrogen bonds bound GluA2. Furthermore, target CFA-treatment suppressed and, as result, alleviated behaviors. Consistently, inhibition chemogenetics mimics THS-induced antinociceptive antianxiety behavior. Together, our study provides evidence for an intervention technique modulating viable clinical treatment strategy anxiety.
Язык: Английский
Процитировано
28
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Окт. 22, 2024
Abstract Mammalian voltage‐gated calcium channels (Ca V ) play critical roles in cardiac excitability, synaptic transmission, and gene transcription. Dysfunctions Ca are implicated a variety of neurodevelopmental disorders. Current pharmacological approaches to enhance activity limited by off‐target effects, drug metabolism issues, cytotoxicity, imprecise modulation. Additionally, genetically‐encoded channel activators optogenetic tools restricted delivery challenges biosafety concerns. Here novel terahertz (THz) wave‐based method upregulate 1.2, key subtype , boost 1‐mediated 2+ signaling neurons without introducing exogenous DNA is presented. Using molecular dynamics simulations, it shown that 42.5 THz (7.05 µm, 1418 cm −1 waves conductance 1.2 resonating with the stretching mode ‐COO − group selectivity filter. Electrophysiological recordings imaging confirm these rapidly, reversibly, non‐thermally increase influx HEK293 cells induce acute signals neurons. Furthermore, this irradiation upregulates 1 signals, including CREB phosphorylation c‐Fos expression, vitro vivo, raising significant risks. This DNA‐free, non‐invasive approach offers promising for modulating gating treating diseases characterized deficits functions.
Язык: Английский
Процитировано
27
Measurement, Год журнала: 2025, Номер unknown, С. 117318 - 117318
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
3
The Analyst, Год журнала: 2024, Номер 149(18), С. 4605 - 4614
Опубликована: Янв. 1, 2024
L-Glutamic acid (L-Glu) is a basic unit of proteins and also serves as an important neurotransmitter in the central nervous system. Its structural properties are critical for biological functions selective receptor recognition. Although this molecule has been extensively studied, low frequency vibrational behavior that closely related to conformational changes intermolecular interactions between L-Glu its receptors still unclear. In study, we acquired fingerprint spectrum by using air plasma terahertz (THz) time-domain spectroscopy 0.5-18 THz range. The characteristics were investigated through density functional theory (DFT) calculations. responses ligand binding domain NMDAR-L-Glu complex studied ONIOM method, with focus on discussing normal modes water molecules. results illustrate exhibits sensitive response influence structure NMDAR. molecules have various strong vibration band, showing specificity, diversity complexity behavior. There potential influencing regulating stability
Язык: Английский
Процитировано
8
Frontiers in Plant Science, Год журнала: 2024, Номер 15
Опубликована: Апрель 8, 2024
Bulbil is an important asexual reproductive structure of bulbil plants. It mainly grows in leaf axils, forks, tubers and the upper near ground ends flower stems They play a significant role reproduction numerous herbaceous plant species by serving as agents propagation, energy reserves, survival mechanisms adverse environmental conditions. Despite extensive research on bulbil-plants regarding their resources, development mechanisms, utilisation, comprehensive review lacking, hindering progress exploiting resources. This paper provides systematic overview research, including bulbil-plant identification stages maturity bulbils, cellular molecular development, factors influencing gene related to multi-bulbil phenomenon its significance, medicinal value breeding application tissue culture technology production. The Temporary Immersion Bioreactor System (TIBS) Terahertz (THz) also discussed, offering blueprint for further resource development. Additionally, additive, seven areas that require attention are proposed: (1) Utilization modern network technologies, such recognition apps or websites, collect identify bulbous resources efficiently extensively; (2) Further cell structures influence bulb development; (3) Investigation regulatory relationship between genes, proteins, metabolites, epigenetics (4) Exploration potential utilization multiple sprouts, medicinal, ecological, horticultural applications; (5) Innovation optimization system bulbils; (6) Comprehensive TIBS large-scale expansion production; (7) To find out common share genetics bulbils flowers.
Язык: Английский
Процитировано
6
Analytical Chemistry, Год журнала: 2024, Номер 96(20), С. 8078 - 8090
Опубликована: Апрель 16, 2024
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTAmplified Biosensors Powered by Endogenous Molecules for Intracellular Fluorescence ImagingYibo Zhou*Yibo ZhouHunan Provincial Key Laboratory of Cytochemistry, School Chemistry and Chemical Engineering, Changsha University Science Technology, 410114, P.R. China*[email protected]More Yibo ZhouView Biographyhttps://orcid.org/0000-0003-1862-9926, Jun ZhangJun ZhangHunan ChinaMore ZhangView Biography, Shuanghong SunShuanghong SunHunan SunView Weiju ChenWeiju ChenHunan ChenView Yuping WangYuping WangHunan WangView Huiqiu ShiHuiqiu ShiHunan ShiView Ronghua Yang*Ronghua YangLaboratory Biology & Traditional Chinese Medicine Research, Ministry Education, College Hunan Normal University, 410081, YangView Biographyhttps://orcid.org/0000-0001-7873-6892, Zhihe Qing*Zhihe QingHunan QingView Biographyhttps://orcid.org/0000-0002-6268-225XCite this: Anal. Chem. 2024, 96, 20, 8078–8090Publication Date (Web):April 15, 2024Publication History Received17 January 2024Accepted8 April 2024Revised7 2024Published online16 inissue 21 May 2024https://pubs.acs.org/doi/10.1021/acs.analchem.4c00329https://doi.org/10.1021/acs.analchem.4c00329review-articleACS PublicationsCopyright © 2024 American SocietyRequest reuse permissionsArticle Views388Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fluorescence,Genetics,Nanoprobes,Noncovalent probes,Peptides proteins Get e-Alerts
Язык: Английский
Процитировано
5
Fundamental Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
3
Research, Год журнала: 2025, Номер 8
Опубликована: Янв. 1, 2025
The study of many phenomena in the terahertz (THz) frequency spectral range has emerged as a promising playground modern science and technology, with extensive applications high-speed communication, imaging, sensing, biosensing. Many THz metamaterial designs explore quantum physics embedded into classical framework exhibiting various unexpected behaviors. For spatial waves, effects inspired by include electromagnetically induced transparency (EIT), Fano resonance, bound states continuum (BICs), exceptional points (EPs) non-Hermitian systems. They facilitate realization functional metadevices applications. on-chip physics-inspired topological metamaterials, photonic analogs insulators, can ensure robust, low-loss propagation suppressed backscattering. These trends open new pathways for data transmission integrated circuits, being crucial upcoming 6G 7G wireless communication technologies. Here, we summarize underlying principles metamaterials highlight latest advances their application band, encompassing both metadevice realizations.
Язык: Английский
Процитировано
0
ACS Materials Letters, Год журнала: 2025, Номер unknown, С. 947 - 953
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
0
Biomedical Optics Express, Год журнала: 2025, Номер 16(4), С. 1546 - 1546
Опубликована: Март 14, 2025
Terahertz biosensors are employed to detect proteins in cancer cells facilitate early diagnosis and monitoring of treatments. By optimizing the design functionality black phosphorus-based sensors, it is possible enhance their sensitivity specificity for specific biomarkers, leading more accurate diagnostic outcomes. The application externally applied magnetic field 455 nm continuous-wave laser further augments cellular responses THz waves, with influences typically surpassing those light fields by 10%-80%. Our results examine photonic properties phosphorus, improve its interaction terahertz create prototypes that can selectively identify associated cells. Additionally, stability reproducibility these sensors have been greatly improved, boosting potential widespread use clinical environments.
Язык: Английский
Процитировано
0