Protein nanoparticles as drug delivery systems for cancer theranostics

Journal of Controlled Release, Год журнала: 2024, Номер 371, С. 429 - 444

Опубликована: Июнь 8, 2024

Язык: Английский

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Radiotherapy-sensitized cancer immunotherapy via cGAS-STING immune pathway by activatable nanocascade reaction

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Май 9, 2024

Abstract Radiotherapy-induced immune activation holds great promise for optimizing cancer treatment efficacy. Here, we describe a clinically used radiosensitizer hafnium oxide (HfO 2 ) that was core coated with MnO shell followed by glucose oxidase (GOx) doping nanoplatform @MnO @GOx, HMG) to trigger ferroptosis adjuvant effects glutathione depletion and reactive oxygen species production. This cascade potentiation further sensitized radiotherapy enhancing DNA damage in 4T1 breast tumor cells. The combination of HMG nanoparticles effectively activated the damaged Mn 2+ -mediated cGAS-STING pathway vitro vivo. process had significant inhibitory on progression initiating an anticancer systemic response prevent distant recurrence achieve long-lasting suppression both primary tumors. Furthermore, as-prepared “turned on” spectral computed tomography (CT)/magnetic resonance dual-modality imaging signals, demonstrated favorable contrast enhancement capabilities under GSH microenvironment. result highlighted potential as theranostic achieving molecular guided sensitization induced synergistic immunotherapy.

Язык: Английский

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Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective

Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 215969 - 215969

Опубликована: Июнь 10, 2024

Язык: Английский

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Tumor Microenvironment Reprogrammed Bimetallic Hybrid Nanostimulator for Triggering Radio‐Cuproptosis‐Immunotherapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(30)

Опубликована: Авг. 13, 2024

Radio-immunotherapy driven by radiation-induced immunogenic cell death (ICD) is emerging as a potential opportunity to address conventional radiotherapy (RT) that only applicable localized tumor treatment. However, the effective activation of ICD during RT severely limited radiation dose, weak immunogenicity, and radio-resistance caused microenvironment (TME). Herein, novel bimetallic hybrid nanoscale coordination nanostimulator first proposed phosphate backbone doped with copper ions (Cu

Язык: Английский

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Cancer Radiosensitization Nanoagent to Activate cGAS‐STING Pathway for Molecular Imaging Guided Synergistic Radio/Chemo/Immunotherapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(14)

Опубликована: Фев. 23, 2024

Abstract Immunotherapy has emerged as an innovative strategy with the potential to improve outcomes in cancer patients. Recent evidence indicates that radiation‐induced DNA damage can activate cyclic‐GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) pathway enhance antitumor immune response. Even so, only a small fraction patients currently benefits from radioimmunotherapy due radioresistance and inadequate activation cGAS‐STING pathway. Herein, this work integrates hafnium oxide (HfO 2 ) nanoparticles (radiosensitizer) 7‐Ethyl‐10‐hydroxycamptothecin (SN38, chemotherapy drug, STING agonist) into polydopamine (PDA)‐coated core‐shell nanoplatform @PDA/Fe/SN38) achieve synergistic chemoradiotherapy immunotherapy. The co‐delivery HfO /SN38 greatly enhances radiotherapy efficacy by effectively activating pathway, which then triggers dendritic cells maturation CD8 + T recruitment. Consequently, growth both primary abscopal tumors tumor‐bearing mice is efficiently inhibited. Moreover, @PDA/Fe/SN38 complexes exhibit favorable magnetic resonance imaging (MRI)/photoacoustic (PA) bimodal molecular properties. In summary, these developed multifunctional have intensify realize simultaneous Radio/Chemo/Immunotherapy for clinical translation.

Язык: Английский

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Robust and Sustained STING Pathway Activation via Hydrogel-Based In Situ Vaccination for Cancer Immunotherapy

ACS Nano, Год журнала: 2024, Номер 18(43), С. 29439 - 29456

Опубликована: Окт. 15, 2024

The stimulator of interferon genes (STING) pathway is crucial for tumor immunity, leading to the exploration STING agonists as potential immunotherapy adjuvants. However, their clinical application faces obstacles including poor pharmacokinetics, transient activation, and an immunosuppressive microenvironment (TME). Addressing these limitations, our study aims develop injectable silk fibroin hydrogel-based in situ vaccine. It incorporates a nanoscale agonist, immunogenic cell death (ICD) inducer, immunomodulator ensure controlled sustained release. cGAMP nanoparticles (cGAMPnps) with core–shell structure optimal delivery dendritic cells (DCs), thereby activating fostering DC maturation. ICD-associated damage-associated molecular patterns amplify prolong activation via enhanced type I IFN other inflammatory pathways, along delayed degradation STING. Furthermore, STING-driven vascular normalization by cGAMPnps ICD, conjunction immunomodulators like antiprogrammed protein 1 antibody (anti-PD-1 Ab) or OX40 ligand (OX40L), effectively remodels TME. This gel vaccine, when used independently surgery neoadjuvant/adjuvant immunotherapy, enhances CD8+ T-cell suppressing progression recurrence across various immunologically cold models. revolutionizes cancer offering substantial promise improving outcomes broad spectrum malignancies.

Язык: Английский

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Application of nanoparticles with activating STING pathway function in tumor synergistic therapy

International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114013 - 114013

Опубликована: Янв. 18, 2025

Язык: Английский

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A dual-warhead high-density lipoprotein mimetic nanomedicine simultaneously regulates stromal extracellular matrix and cGAS/STING activation for potent immunotherapy of cancer

Nano Today, Год журнала: 2025, Номер 61, С. 102656 - 102656

Опубликована: Фев. 5, 2025

Язык: Английский

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Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy

Journal of Controlled Release, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Dual‐Functional Hafnium Oxide Nanoplatform Combining High‐Z Radiosensitization With Bcl‐2 Gene Silencing for Enhanced Cancer Radiotherapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract The efficacy of radiotherapy is often limited by insufficient radiosensitization and tumor radioresistance. This study reports a dual‐functional hafnium oxide nanoplatform that combines high‐Z with Bcl‐2 gene silencing for enhanced cancer radiotherapy. developed surface modification nanoparticles polyethyleneimine, enabling efficient siRNA delivery while maintaining inherent radiosensitizing properties. Comprehensive physicochemical characterization confirmed the successful stable complexation. Upon radiation exposure, reactive oxygen species generation DNA damage simultaneously delivering to suppress radioresistance mechanisms. In vitro studies revealed significant enhancement radiation‐induced cell death through synergistic effects silencing, evidenced increased γ‐H2AX expression apoptotic population. murine colon model, achieved remarkable growth inhibition (80%) when combined exhibiting favorable biocompatibility in major organs. Mechanistic effective downregulation tissues, validating this therapeutic approach. presents promising strategy improving outcomes simultaneous suppression radioresistance, potentially advancing field

Язык: Английский

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