Nanosystems for targeted drug Delivery: Innovations and challenges in overcoming the Blood-Brain barrier for neurodegenerative disease and cancer therapy

International Journal of Pharmaceutics, Год журнала: 2024, Номер 666, С. 124800 - 124800

Опубликована: Окт. 5, 2024

Язык: Английский

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A review on brain-targeting nano-based drug delivery

Chinese Science Bulletin (Chinese Version), Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Nanomedicines for the treatment of ischemic stroke: an overview of recent advances

Precision medicine and engineering., Год журнала: 2025, Номер unknown, С. 100022 - 100022

Опубликована: Фев. 1, 2025

Язык: Английский

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Nanoparticles Designed Based on the Blood‐Brain Barrier for the Treatment of Cerebral Ischemia‐Reperfusion Injury

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Cerebral ischemia-reperfusion injury (CI/RI) is currently considered a significant factor affecting the prognosis of ischemic stroke. The blood-brain barrier (BBB) plays multiple roles in treatment ofCI/RI. BBB leakage allows bloodborne toxins to exacerbate stroke pathology. Yet as physiological that separates blood from brain, also poses obstacle therapeutic drug delivery. Therefore, it essential consider both crossing and repairing process CI/RI. Leveraging exceptional benefits nanoparticles (NPs) for penetration targeted repair, numerous NPs are developed promising delivery platforms. Considering complex role CI/RI, this review delves into strategies designing cross BBB, focusing on peptide-modified NPs, cell-mediated cell membrane-derived BBB-modulating NPs. Additionally, summarizes design targeting endothelial cells (ECs), astrocytes, those aimed at regulating microenvironment repair BBB. On basis, reveals prospects challenges designed around CI/RI treatment. And highlights need combine permeability promotion nanoparticle based achieve more effective

Язык: Английский

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Hierarchical Targeting Nanoplatform for NIR‐II Photoacoustic Imaging and Photo‐Activated Synergistic Immunotherapy of Glioblastoma

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Abstract Glioblastoma (GBM) stands as the most aggressive malignant brain tumor, characterized by poor prognosis, high recurrence rate, and resistance to multiple therapies, posing a significant clinical challenge. Here, hierarchical targeting platform is presented for NIR‐II photoacoustic (PA) imaging‐guided photo‐chemo synergistic immunotherapy of GBM. A new molecular probe developed with exceptional light‐harvesting capabilities enhanced motion, boosting both photothermal conversion PA signal. This probe, combined thermo‐responsive prodrug, assembled into nanoparticles that are further camouflaged tumor cell membranes bioorthogonally modified transferrin‐mimicking peptide, facilitating blood‐brain barrier penetration GBM targeting. High‐contrast imaging allows precise detection delineation GBM, providing accurate guidance subsequent treatment. The light‐triggered effect, coupled hyperthermia‐activated significantly induces immunogenic death, enhancing tumor‐killing efficiency amplifying anti‐tumor immune response. self‐synergistic not only stimulates robust immunity inhibits primary growth but also prevents post‐surgical recurrence, prolonging survival time. work exemplifies novel paradigm tackling diagnostic therapeutic challenges posed deeply seated poorly tumors.

Язык: Английский

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Myricetin induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Myricetin is a natural flavonol glycoside that widely found in the fruits, bark and leaves of plant. have been reported to possess variety biological activi-ties, such as antioxidant properties, anti-inflammatory effects, antitumor activity. In this study, we demonstrated for hyperoside inhibited prolifer-ation bladder cancer cells vitro vivo. Moreover, could not only induce cell cycle arrest, but also apoptosis cells. Bioinformat-ics analysis showed myricetin may act mainly through EGFR-Ras Fas sig-naling pathways. experiments activated signaling pathways, up-regulated protein levels EGFR, Ras Fas. Then further downstream proteins MAPK Akt. Through interac-tion signaling, it ultimately promotes its anticancer effects on This study suggests be promising therapeutic clinical candidate cancer.

Язык: Английский

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CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Abstract The damage of blood spinal cord barrier (BSCB) is contributing to the disruption immune microenvironment within central nervous system during progression multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE). Nevertheless, underlying mechanisms responsible for impairment remain inadequately understood. Here, by analyzing protein profiles in peripheral serum, chemokine (C‐X‐C motif) ligand 13 (CXCL13) was identified be increased with MS EAE. absence CXCL13 resulted alleviation EAE symptoms, as evidenced a reduced clinical score, decreased damage, well diminished demyelination inflammatory response cord. In BSCB model, found impair structure function dose‐ time‐dependent manner, which associated exacerbated autophagy endothelial cells, while application inhibitors partially mitigated this damage. Mechanistically, enhanced expression RNF6, an E3 ubiquitin‐protein ligase, facilitating conjugation Sqstm1 ubiquitination at K314 residue. These findings suggest that significantly contributes promoting RNF6/Sqstm1‐ubiquitination‐induced EAE, thereby offering promising diagnostic therapeutic target MS.

Язык: Английский

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Curcumin-Loaded Gelatin Nanoparticles Cross the Blood-Brain Barrier to Treat Ischemic Stroke by Attenuating Oxidative Stress and Neuroinflammation

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11633 - 11649

Опубликована: Ноя. 1, 2024

Ischemic stroke is a medical emergency for which effective treatment remains inadequate. Curcumin (Cur) natural polyphenolic compound that regarded as potent neuroprotective agent. Compared to synthetic pharmaceuticals, Cur possesses minimal side effects and exhibits multiple mechanisms of action, offering significant advantages in the ischemic stroke. However, drawbacks such poor water solubility transmembrane permeability limit efficacy Cur. In recent years, nano-delivery systems have attracted great interest field therapy an method improve drug cross blood-brain barrier (BBB).

Язык: Английский

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Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 27, 2024

Abstract Background Ulcerative colitis (UC) is a chronic intestinal inflammation, resulting in global healthcare challenge with no real specific medicine. Natural medicines are recognized as potential clinical alternative therapy, but their applications limited by poor solubility and low bioavailability. Results In this work, inspired the natural of ancient China, novel functional carbon dots derived from Magnetite Medicated Leaven (MML-CDs) were synthesized hydrothermal method, confirmed ultrasmall nano-size (3.2 ± 0.6 nm) Fe doped surface structure, thereby excellent gastrointestinal stability, remarkable capabilities eliminating ROS, highly biocompatibility. With external stimuli, oral administration MML-CDs demonstrated obvious alleviation to UC. Further experiments pointed that could improve hemostasis capability, suppress inflammation reactions oxidative stress, up-regulate expression tight junction proteins. Furthermore, also showed well regulation dysbiosis flora. Conclusion Overall, above evidence reveals green-synthesized can significantly alleviate bleeding, inhibit colon repair colonic barrier damage, further regulating flora microenvironment. Our findings provide an efficient therapy strategy for ulcerative colitis. Graphical

Язык: Английский

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Curcumin-Loaded Gelatin Nanoparticles Cross the Blood-Brain Barrier to Treat Stroke by Attenuating Oxidative Stress and Neuroinflammation

Опубликована: Янв. 1, 2024

Язык: Английский

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