Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(13), С. 2049 - 2067
Опубликована: Июль 12, 2024
Cartilage
tissue
engineering
holds
great
promise
for
efficient
cartilage
regeneration.
However,
early
inflammatory
reactions
to
seed
cells
and/or
scaffolds
impede
this
process.
Consequently,
managing
inflammation
is
of
paramount
importance.
Moreover,
due
the
body's
restricted
chondrogenic
capacity,
inducing
regeneration
becomes
imperative.
Thus,
a
controlled
platform
essential
establish
an
anti-inflammatory
microenvironment
before
initiating
In
study,
we
utilized
fifth-generation
polyamidoamine
dendrimers
(G5)
as
vehicle
drugs
create
composite
nanoparticles
known
G5-Dic/Sr.
These
were
generated
by
surface
modification
with
diclofenac
(Dic),
its
potent
effects,
and
encapsulating
strontium
(Sr),
which
effectively
induces
chondrogenesis,
within
core.
Our
findings
indicated
that
G5-Dic/Sr
nanoparticle
exhibited
selective
Dic
release
during
initial
9
days
gradual
Sr
from
3
15.
Subsequently,
these
incorporated
into
gelatin
methacryloyl
(GelMA)
hydrogel,
resulting
in
GelMA@G5-Dic/Sr.
Abstract
Chronic
wounds
pose
a
significant
clinical
challenge
worldwide,
which
is
characterized
by
impaired
tissue
regeneration
and
excessive
scar
formation
due
to
over‐repair.
Most
studies
have
focused
on
developing
wound
repair
materials
that
either
facilitate
the
healing
process
or
control
hyperplastic
scars
caused
over‐repair,
respectively.
However,
there
are
limited
reports
can
both
promote
prevent
hyperplasia
at
same
time.
In
this
study,
VR23‐loaded
dendritic
mesoporous
bioglass
nanoparticles
(dMBG)
synthesized
electrospun
in
poly(ester‐curcumin‐urethane)urea
(PECUU)
random
composite
nanofibers
(PCVM)
through
synergistic
effects
of
physical
adsorption,
hydrogen
bond,
electrospinning.
The
physicochemical
characterization
reveals
PCVM
presented
matched
mechanical
properties,
suitable
porosity,
wettability,
enabled
sustained
temporal
release
VR23
BDC
with
degradation
PCVM.
vitro
experiments
demonstrated
modulate
functions
polarization
macrophages
under
an
inflammatory
environment,
possess
effective
anti‐scarring
potential
reliable
cytocompatibility.
Animal
further
confirmed
efficiently
re‐epithelialization
angiogenesis
reduce
inflammation,
thereby
remarkably
accelerating
while
preventing
scarring.
These
findings
suggest
prepared
holds
promise
as
bidirectional
regulatory
dressing
for
effectively
promoting
scar‐free
chronic
wounds.
Advanced Engineering Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Over
the
past
two
decades,
remarkable
advancements
have
been
achieved
in
stimulus‐responsive
shape‐memory
polymers
(SMPs),
which
exhibit
desirable
properties
such
as
characteristics,
deformability,
and
biocompatibility,
while
responding
to
external
stimuli.
The
development
of
polymer
composites
(SMPCs)
leads
high
recovery
forces
novel
functionalities,
including
electrical
actuation,
magnetic
biocompatibility.
enhanced
remotely
controllable
functionality
further
expand
application
SMPs
biomedical
areas,
surgical
applications
for
replacing
handheld
instruments
drug
delivery
systems.
In
this
review,
device
SMPCs
are
focused
on
their
recent
bone
tissue
scaffolds,
lumen
stents,
carriers
examined.
Furthermore,
bottlenecks
challenges
encountered
by
devices
elucidated.
future
trend
is
also
discussed,
aiming
provide
valuable
insights
broadening
fields.
Journal of Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
ABSTRACT
Shape
memory
polymers
(SMPs)
are
novel
kinds
of
smart
materials
whose
shape
can
be
changed
in
external
conditions
such
as
heat
stimulus.
Due
to
their
excellent
structural
versatility
and
high
elastic
strain,
they
have
important
applications
the
field
biomaterials.
Here,
a
series
amorphous
polymer
prepared
properties
glass
transition
temperature
(
T
g
)
also
investigated.
A
special
kind
epoxy
polymer,
at
around
physiological
temperature,
is
synthesized
by
regulating
crosslinking
density
introducing
flexible
aliphatic
chains.
The
function
this
studied
deformation
test.
In
addition,
explore
application
biomedical
materials,
biocompatibility
evaluated,
including
effects
on
erythrocyte
hemolysis
rate
cell
activity.
experimental
results
show
that
has
good
biocompatibility.
Bioactive Materials,
Год журнала:
2024,
Номер
39, С. 354 - 374
Опубликована: Май 28, 2024
Osteoporosis
is
majorly
caused
by
an
imbalance
between
osteoclastic
and
osteogenic
niches.
Despite
the
development
of
nationally
recognized
first-line
anti-osteoporosis
drugs,
including
alendronate
(AL),
their
low
bioavailability,
poor
uptake
rate,
dose-related
side
effects
present
significant
challenges
in
treatment.
This
calls
for
urgent
need
more
effective
bone-affinity
drug
delivery
systems.
In
this
study,
we
produced
hybrid
structures
with
bioactive
components
stable
fluffy
topological
morphology
cross-linking
calcium
phosphorus
precursors
based
on
mesoporous
silica
to
fabricate
nanoadjuvants
AL
delivery.
The
subsequent
grafting
-PEG-DAsp8
ensured
superior
biocompatibility
bone
targeting
capacity.
RNA
sequencing
revealed
that
these
effectively
activated
adhesion
pathways
through
CARD11
CD34
molecular
mechanisms,
hence
promoting
cellular
intracellular
AL.
Experiments
showed
small-dose
suppress
osteoclast
formation
potentially
promote
osteogenesis.
vivo
results
restored
balance
niches
against
osteoporosis
as
well
consequent
recovery
mass.
Therefore,
study
constructed
a
nanoadjuvant
peculiar
high
capacities,
efficient
bioactivity.
provides
novel
perspective
treatment
strategies
other
diseases.
