Rational Design of NIR‐II Ratiometric Fluorescence Probes for Accurate Bioimaging and Biosensing In Vivo

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Март 12, 2024

Abstract Intravital fluorescence imaging in the second near‐infrared window (NIR‐II, 900–1700 nm) has emerged as a promising method for non‐invasive diagnostics complex biological systems due to its advantages of less background interference, high tissue penetration depth, contrast, and sensitivity. However, traditional NIR‐II imaging, which is characterized by “always on” or “turn mode, lacks ability quantitative detection, leading low reproducibility reliability during bio‐detection. In ratiometric can realize reliable analysis detection vivo providing reference signals correction, generating new opportunities prospects bioimaging biosensing. this review, current design strategies sensing mechanisms probes biosensing applications are systematically summarized. Further, challenges, future perspectives designing also discussed. It hoped that review provide effective guidance promote adoption vivo.

Язык: Английский

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Metal-organic frameworks based fluorescent sensing: Mechanisms and detection applications

Coordination Chemistry Reviews, Год журнала: 2025, Номер 529, С. 216470 - 216470

Опубликована: Янв. 28, 2025

Язык: Английский

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Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer

Exploration, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

ABSTRACT The advancements in early stratification and timely evaluation of therapeutic effects have revolutionized the ability to assess curative outcomes promptly. separation between diagnosis/treatment assessment treatment response, along with delays evaluating therapy efficacy, are significant contributors failures. Traditional approaches for face challenges posed by tumor heterogeneity resistance, making it challenging determine effectiveness a given regimen at an stage clinical practice. However, molecular imaging using activatable probes has overcome these obstacles transformed field shifting focus towards developing functional visualizing tumors as well enabling or effects. In this article, we emphasize importance diverse provide insights into various therapies’ Finally, discuss faced propose future research directions.

Язык: Английский

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Frontiers in Fluorescence imaging: Tools for the In-Situ Sensing of Disease Biomarkers

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

A comprehensive overview of recent advancements in fluorescence imaging techniques for situ sensing various biomarkers, emphasizing the transformative potential artificial intelligence shaping future bioimaging.

Язык: Английский

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Enzyme-Free Nano-Sensor for High-Sensitivity miRNA Detection and Tumor Imaging Based on Multicolor Silver Nanoclusters Pair and DNA-Mediated CHA Reactions

Sensors and Actuators B Chemical, Год журнала: 2025, Номер 427, С. 137222 - 137222

Опубликована: Янв. 5, 2025

Язык: Английский

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Polypyrrole@MnO2 fluorescence nanocomposites as a multifunctional architecture for glutathione sensing and synergistic therapy of cancer

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 112852 - 112852

Опубликована: Янв. 1, 2025

Язык: Английский

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Functional Nucleic Acid-based Fluorescence Imaging for Tumor Microenvironment Monitoring: A Review

Analytica Chimica Acta, Год журнала: 2025, Номер 1350, С. 343794 - 343794

Опубликована: Фев. 13, 2025

Язык: Английский

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A NIR and ratiometric fluorescent probe for quantitative detection of SO2 derivatives in Chinese medicinal materials and bioimaging in vivo

Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110979 - 110979

Опубликована: Фев. 1, 2025

Язык: Английский

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Development of a Mitochondria-Targeted Ruthenium(II)-Based Phosphorescent Probe for Hypochlorite Detection in Acute Inflammatory Model

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

The uncontrolled acute inflammatory response triggers dysregulation of the immunoinflammatory system, contributing to development and progression various diseases (AIDs). Hypochlorite (ClO–), as a crucial oxidative mediator in AIDs, accumulates environment, leading direct cytotoxicity, secondary injury, tissue dysfunction. However, achieving rapid detection, accurate tracking, situ monitoring, real-time imaging ClO– vivo remains significant challenge. To address these issues, we developed mitochondria-targeted phosphorescent probe (RuDM), which introduces ligand containing C═N bond recognition site precisely identify AIDs. It responds rapidly (6 s) exhibits long-lived luminescence (471 ns), with 190-fold enhancement monitoring ClO–. Meanwhile, density functional theory (DFT) indicates that RuCOOH is attributed removal an electron-withdrawing group (diaminomaleonitrile) from RuDM, leads increase intersystem crossing rate greater probability radiative transition T1 state. Finally, RuDM used monitor levels exogenous endogenous cells using confocal microscopy evaluate its capability for detection over time model. above results suggest novel molecular platform detect ClO–, has potential practical tool research on pathogenesis diseases.

Язык: Английский

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A portable photoelectrochemical aptasensor based on voltage−resolved dual−signal output for the determination of chloramphenicol

Journal of Hazardous Materials, Год журнала: 2025, Номер 490, С. 137748 - 137748

Опубликована: Фев. 27, 2025

Язык: Английский

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