International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125548 - 125548
Опубликована: Апрель 1, 2025
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(38)
Опубликована: Авг. 5, 2024
As a form of dementia, Alzheimer's disease (AD) suffers from no efficacious cure, yet AD treatment is still imperative, as it ameliorates the symptoms or prevents deteriorating maintains current status to longest extent. The human brain most sensitive and complex organ in body, which protected by blood-brain barrier (BBB). This induces difficulty curing drugs nanomaterials that are much inhibited reaching lesion site. Thus, BBB crossing capability drug delivery system remains significant challenge development neurological therapeutics. Fortunately, nano-enabled systems possess promising potential achieve multifunctional diagnostics/therapeutics against various targets owing their intriguing advantages nanocarriers, including easy multifunctionalization on surfaces, high surface-to-volume ratio with large payloads, ability cross BBB, making them capable conquering limitations conventional candidates. review, focuses diagnosis treatment, will provide an insightful vision conducive AD-related nanomaterials.
Язык: Английский
Процитировано
6
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134962 - 134962
Опубликована: Авг. 22, 2024
Язык: Английский
Процитировано
6
Pharmacological Research, Год журнала: 2024, Номер 206, С. 107308 - 107308
Опубликована: Июль 15, 2024
Glioma is the most common intracranial malignant tumor, with severe difficulty in treatment and a low patient survival rate. Due to heterogeneity invasiveness of tumors, lack personalized clinical design, physiological barriers, it often difficult accurately distinguish gliomas, which dramatically affects subsequent diagnosis, imaging treatment, prognosis. Fortunately, nano-delivery systems have demonstrated unprecedented capabilities diagnosing treating gliomas recent years. They been modified surface efficiently traverse BBB/BBTB, target lesion sites, intelligently release therapeutic or contrast agents, thereby achieving precise treatment. In this review, we focus on systems. Firstly, provide an overview standard emerging diagnostic technologies for glioma practice. After induction analysis, summarizing delivery methods drug systems, design nanoparticles, their new advances Finally, discussed prospects potential challenges drug-delivery glioma.
Язык: Английский
Процитировано
5
Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 9, 2025
Abstract Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its immunosuppressive microenvironment and the immune privilege. Immunotherapy activating system T lymphocyte infiltration holds great promise against GBM. However, brain’s low immunogenicity difficulty of crossing blood-brain barrier (BBB) hinder therapeutic efficacy. Recent advancements in immune-actuated particles for targeted drug delivery have shown potential overcome these obstacles. These interact with BBB by rapidly reversibly disrupting structure, thereby significantly enhancing targeting penetrating delivery. The also minimizes long-term damage. At GBM, demonstrated effective chemotherapy, chemodynamic therapy, photothermal therapy (PTT), photodynamic (PDT), radiotherapy, or magnetotherapy, facilitating tumor disruption promoting antigen release. Additionally, components retained autologous tumor-associated antigens presented them dendritic cells (DCs), ensuring prolonged activation. This review explores mechanisms existing strategies, role nanomaterials immunotherapy. We discuss innovative particle-based approaches designed traverse mimicking innate functions improve outcomes tumors. Graphical
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Treatment of tumor brain metastases remains challenging due to the ineffectiveness drugs in crossing blood–brain barrier (BBB). Here, we proposed a potential strategy target and modulate meningeal lymphatic system for immunotherapy breast cancer (BCBM) through peripheral administration. CT/fluorescence dual-modality imaging demonstrated that phospholipid nanoprobe (α-PLNPs) intracisternal magna injection effectively labeled long-range tracked pathway from vessels (MLVs) periphery drainage cervical lymph nodes (CLNs). Interestingly, reverse CLNs MLVs was also successfully with α-PLNPs subcutaneous injection, facilitating noninvasive delivery immunomodulators lymphatics. Given this, used melittin-carrying α-M-PLNPs trigger modulation pathway, which prevents BCBM prolongs survival mice activating antigen-presenting cells promoting migration CD8+ T into metastatic tumors. This study highlights BCBM, holds great promise central nervous disease therapy without need drug via BBB.
Язык: Английский
Процитировано
0
Neurochemical Research, Год журнала: 2025, Номер 50(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
0
Journal of Nanotheranostics, Год журнала: 2025, Номер 6(1), С. 4 - 4
Опубликована: Янв. 31, 2025
Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 532, С. 216527 - 216527
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
0
Drug Delivery and Translational Research, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Март 6, 2025
Monoclonal antibodies (mAbs) and antibody fragments have revolutionized medicine as highly specific binding agents inhibitors. At the same time, several types of nanomaterials, including liposomes, lipid nanoparticles (NPs), polymersomes, metal oxide NPs, protein nanostructures, are increasingly utilized explored for therapeutic potential due to their versatility, chemical physical properties, tunability. However, nanomaterials alone often lack specificity, leading relatively low efficacy and/or high toxicity. To address this problem, a rapidly emerging area is antibody-nanomaterial conjugates (ANCs), which combine precise targeting specificity with effector functionality nanomaterial. In review, we give brief introduction mAbs major conjugation techniques, describe classes being studied potential, review literature on ANCs each class. Special focus given applications addressing blood-brain barrier, delivering nucleic acids, light-activated ANCs. While many disease targets related cancer, also under development autoimmune, neurological, infectious diseases. important challenges remain, poised become next-generation technology.
Язык: Английский
Процитировано
0