New insights into the reproductive hazards posed by polystyrene nanoplastics

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138210 - 138210

Опубликована: Апрель 1, 2025

Язык: Английский

---

Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 20, 2025

Migrasomes are newly identified organelles that were first discovered in 2015. Since then, their biological structure, formation process, and physiological functions have been gradually elucidated. Research recent years has expanded our understanding of these aspects, highlighting significance various pathological processes. found to play crucial roles normal functions, including embryonic development, vascular homeostasis, material transport, mitochondrial quality control. Additionally, emerging evidence suggests involvement diseases; however, clinical research on remains limited. Current studies indicate migrasomes may contribute disease pathogenesis hold potential for diagnostic therapeutic applications. This review consolidates existing migrasomes, focusing role mechanisms use medical By examining structure function, this aims generate insights encourage further research, ultimately contributing advancements prevention treatment.

Язык: Английский

---

BaP/BPDE suppresses human trophoblast cell migration/invasion and induces unexplained miscarriage by up-regulating a novel lnc-HZ11 in extracellular vesicles: An intercellular study

Environment International, Год журнала: 2024, Номер 188, С. 108750 - 108750

Опубликована: Май 21, 2024

Extracellular vesicles (EVs) mediate the intercellular crosstalk by transferring functional cargoes. Recently, we have discovered that BaP/BPDE exposure suppresses trophoblast cell migration/invasion and induces miscarriage, which are also regulate lncRNAs at intracelluar levels. However, EVs-mediated regulatory mechanisms completely unexplored. Specifically, whether EVs might transfer BPDE-induced toxic lncRNA to fresh recipient cells suppress their further induce miscarriage is unknown. In this study, find BPDE up-regulates a novel lnc-HZ11, EGR1/NF-κB/CXCL12 pathway of cells. Intercellular studies show EV-HZ11 (lnc-HZ11 in EVs), highly expressed BPDE-exposed donor cells, lnc-HZ11 through EVs. Analysis villous tissues collected from UM (unexplained miscarriage) patients HC (healthy control) group shows levels BPDE-DNA adducts, or EV-lnc-HZ11, all associated with miscarriage. Mouse assays BaP lnc-Hz11 EV-Hz11, Egr1/Nf-κb/Cxcl12 pathway, eventually Knockdown injecting EV-AS-Hz11 could effectively alleviate BaP-exposed mice. Furthermore, serum samples well predict risk Collectively, study not only discovers EVs-HZ11-mediated but provides new approach for treatment against unexplained EV-HZ11.

Язык: Английский

---

Micro/Nanoplastic Exposure on Placental Health and Adverse Pregnancy Risks: Novel Assessment System Based upon Targeted Risk Assessment Environmental Chemicals Strategy

Toxics, Год журнала: 2024, Номер 12(8), С. 553 - 553

Опубликована: Июль 30, 2024

Micro/nanoplastics (MNPs), as emerging pollutants, have been detected in both the maternal and fetal sides of placenta pregnant women, their reproductive toxicity has demonstrated vivo vitro experimental models. The Targeted Risk Assessment Environmental Chemicals (TRAEC) strategy innovatively devised to facilitate valid risk assessment, encompassing a comprehensive evaluation reliability, correlation, outcome fitness, integrity across four dimensions based on included published evidence our own findings. This study serves an application case TRAEC, with 40 items research MNPs placenta, which were rigorously screened incorporated into final scoring system. score for this TRAEC is 5.63, suggesting moderate-to-low associated may potentially increase decreasing particle size. It essential emphasize that findings also report original data from assays indicating exposure high-dose groups (100 μg/mL, 200 μg/mL) 50 nm polystyrene nanoplastics (PS-NPs) induces HTR8/SVneo cell cycle arrest apoptosis, lead by disrupting mitochondrial function. Overall, employed provide insight potential health effects ubiquitous MNPs.

Язык: Английский

---

Fabrication of novel metal oxide nanosheets-decorated carbon nanofibers for highly efficient removal of ultra-small nanoplastics

Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(5), С. 114094 - 114094

Опубликована: Сен. 12, 2024

Язык: Английский

---