An adaptive biodegradable zinc alloy with bidirectional regulation of bone homeostasis for treating fractures and aged bone defects
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 207 - 224
Опубликована: Май 6, 2024
Healing
of
fractures
or
bone
defects
is
significantly
hindered
by
overactivated
osteoclasts
and
inhibited
osteogenesis
in
patients
with
abnormal
metabolism.
Current
clinical
approaches
using
titanium
alloys
stainless
steel
provide
mechanical
support
but
have
no
biological
effects
on
regeneration.
Therefore,
designing
fabricating
degradable
metal
materials
sufficient
strength
bidirectional
regulation
both
osteoblasts
a
substantial
challenge.
Here,
this
study
first
reported
an
adaptive
biodegradable
Zn-0.8
Mg
alloy
homeostasis,
which
promotes
osteogenic
differentiation
activating
the
Pi3k/Akt
pathway
inhibits
osteoclast
inhibiting
GRB2/ERK
pathway.
The
Язык: Английский
Precisely targeted drug delivery by mesenchymal stem cells-based biomimetic liposomes to cerebral ischemia-reperfusion injured hemisphere
Journal of Controlled Release,
Год журнала:
2024,
Номер
371, С. 484 - 497
Опубликована: Июнь 11, 2024
Язык: Английский
Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
690, С. 137332 - 137332
Опубликована: Март 14, 2025
Язык: Английский
Neutrophil-Mediated Tumor Discrimination Biomimetic Nanodevice for Precise Tumor Eradication and Metastasis Cascade Perturbing
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 12, 2025
The
deficient
discrimination
of
tumor
cells,
limited
accumulation
therapeutic
agents
in
foci,
and
undesirable
metastasis
result
compromised
efficacy
antitumor
therapy.
Neutrophils,
the
most
abundant
circulating
leukocytes,
are
key
players
progression
have
a
high
affinity
to
tumors.
Herein,
biomimetic
nanodevice
(NL-FSB)
is
developed
by
harboring
pH-sensitive
Fenton
agent
(FSB)
an
activated
neutrophil
membrane-incorporated
liposome
for
tumor-specific
ablation.
Inheriting
biointerfacing
properties
neutrophils,
NL-FSB
endowed
with
On
one
hand,
can
be
recruited
acidic
sites
mediated
chemotaxis
attraction
selectively
generate
reactive
oxygen
species
via
amplified
chemical
reaction
specific
eradication.
other
also
target
bind
vascular
endothelium
or
cells
(CTCs)
circulation,
executing
pseudo
escort
perturb
CTC-neutrophil
cluster
formation
cascade.
Unprecedentedly,
neutrophil-mediated
nanoagent
effectively
inhibit
already-formed
prevent
specificity.
Our
study
represents
promising
yet
simple
strategy
killing
cascade
blockage
nanobioengineering
functionalization
strategy.
Язык: Английский
Blood Cell Membrane-Coated Nanomaterials as a Versatile Biomimetic Nanoplatform for Antitumor Applications
Nanomaterials,
Год журнала:
2024,
Номер
14(21), С. 1757 - 1757
Опубликована: Окт. 31, 2024
The
application
of
nanomaterials
in
tumor
therapy
is
increasingly
widespread,
offering
more
possibilities
for
enhanced
therapy.
However,
the
unclear
biological
distribution
and
metabolism
may
lead
to
immune
rejection
or
inflammatory
reactions,
posing
numerous
challenges
their
clinical
translation.
rich
diversity
multifaceted
functions
blood
cells
offer
promising
avenues
enhancing
nanoparticles
cancer
Blood
cell
membranes,
being
made
naturally
found
components
body,
exhibit
significant
biocompatibility,
which
can
reduce
body’s
response,
extend
drug’s
residence
time
bloodstream,
enhance
its
bioavailability.
Integrating
membranes
with
enhances
by
improving
targeted
delivery,
prolonging
circulation
time,
evading
responses.
This
review
summarizes
recent
advancements
membrane-coated
antitumor
therapy,
a
particular
focus
on
use
photodynamic
photothermal
treatments.
Additionally,
it
explores
potential
synergistic
effects
when
combined
other
therapeutic
modalities.
Язык: Английский
Knowledge landscape of tumor-associated neutrophil: a bibliometric and visual analysis from 2000-2024
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 4, 2024
Background
Neutrophils
have
long
been
consistently
adjudged
to
hold
a
dominant
position
in
acute
inflammation,
which
once
led
people
undervalue
their
role
chronic
malignancy.
It
is
now
acknowledged
that
neutrophils
also
infiltrate
into
the
tumor
microenvironment
substantial
quantities
and
form
highly
abundant
immune
population
within
tumor,
known
as
tumor-associated
(TANs).
There
has
surge
of
interest
researching
eminent
heterogeneity
plasticity
TANs
recent
years,
scholars
increasingly
cotton
on
multifaceted
functions
so
strenuous
endeavors
devoted
enunciating
potential
therapeutic
targets.
Yet
it
remains
much
left
translate
TAN-targeted
immunotherapies
clinical
practice.
Therefore,
there
great
significance
comprehensively
appraise
research
status,
focal
point,
evolution
trend
TAN
by
using
bibliometric
analysis.
Methods
Publications
related
from
2000
2024
are
extracted
Web
Science
Core
Collection.
Bibliometric
analysis
visualization
were
performed
tools
encompassing
Microsoft
Excel,
VOSviewer,
CiteSpace,
R-bibliometrix,
on.
Results
The
included
total
788
publications
authored
5291
affiliated
with
1000
institutions
across
58
countries/regions,
relevant
articles
published
324
journals.
Despite
China’s
maximum
quantity
top
10
institutions,
United
States
leading
country
most
high-quality
global
cooperation
center.
FRONTIERS
IN
IMMUNOLOGY
papers,
whereas
CANCER
RESEARCH
highest
co-cited
journal.
Israeli
professor
Fridlender,
Zvi
G.
founder,
pioneer,
cultivator
citation
counts
H-index
area.
Our
prefigures
future
trajectories:
heterogeneity,
neutrophil
extracellular
trap,
crosstalk
between
immunocytes,
immunotherapy
will
likely
be
focus
research.
Conclusion
A
comprehensive
visual
first
map
current
landscape
intellectual
structure
TAN,
proffers
fresh
perspectives
for
further
accurate
identification
distinct
subpopulations
precise
targeting
key
pro-tumor/anti-tumor
immense
develop
immunotherapy.
Язык: Английский
Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform
Weichong He,
Wei Lv,
Linfeng Liu
и другие.
ACS Nano,
Год журнала:
2024,
Номер
18(52), С. 35559 - 35574
Опубликована: Дек. 19, 2024
Glioblastoma,
the
most
prevalent
malignant
brain
tumor,
is
a
lethal
threat
to
human
health,
with
aggressive
and
infiltrative
growth
characteristics
that
compromise
clinical
treatment.
Herein,
we
developed
vitamin
D3-inserted
lipid
hybrid
neutrophil
membrane
biomimetic
multimodal
nanoplatform
(designated
as
NED@MnO2-DOX)
through
doxorubicin
(DOX)-loaded
manganese
dioxide
nanoparticles
(MnO2)
which
were
coated
membrane.
It
was
demonstrated
in
addition
chemotherapy
chemo-dynamic
therapy
efficacy,
NED@MnO2-DOX
exhibited
great
power
activate
amplify
immune
responses
related
cGAS
STING
pathway,
bolstering
secretion
of
type
I
interferon-β
proinflammatory
cytokines,
promoting
maturation
DC
cells
infiltration
CD8+T
into
glioma
tissue,
thereby
reversing
immunosuppressive
microenvironment
from
"cold"
tumor
"hot"
tumor.
The
has
potential
strategy
for
glioma-targeted
treatment,
especially
holding
considerable
promise
development
innate
glioma.
Язык: Английский
[
Xiaoqi Li,
Xiao Sun,
Hua Lin
и другие.
PubMed,
Год журнала:
2024,
Номер
41(3), С. 620 - 626
Опубликована: Июнь 25, 2024
Near-infrared
fluorescence
imaging
technology,
which
possesses
superior
advantages
including
real-time
and
fast
imaging,
high
spatial
temporal
resolution,
deep
tissue
penetration,
shows
great
potential
for
tumor
Язык: Английский
Developing Cell-Membrane-Associated Liposomes for Liver Diseases
Dongxue Ge,
Ran An,
Lingling Xue
и другие.
ACS Nano,
Год журнала:
2024,
Номер
18(43), С. 29421 - 29438
Опубликована: Окт. 15, 2024
Over
the
past
decade,
a
marked
escalation
in
prevalence
of
hepatic
pathologies
has
been
observed,
adversely
impacting
quality
life
for
many.
The
predominant
therapeutic
strategy
liver
diseases
pharmacological
intervention;
however,
its
efficacy
is
often
constrained.
Currently,
liposomes
are
tiny
structures
that
can
deliver
drugs
directly
to
targeted
areas,
enhancing
their
effectiveness.
Specifically,
cell
membrane-associated
have
gained
significant
attention.
Despite
this,
there
still
much
learn
about
binding
mechanism
this
type
liposome.
Thus,
review
comprehensively
summarizes
relevant
information
on
liposomes,
including
clinical
applications
and
future
development
directions.
First,
we
will
briefly
introduce
composition
types
liposomes.
We
provide
an
overview
structure
discuss
various
associated
with
membranes.
Second,
thoroughly
strategies
drug
delivery
using
these
Lastly,
application
challenges
treating
diseases.
explore
potential
benefits
while
also
addressing
obstacles
need
be
overcome.
Furthermore,
prospects
field.
In
summary,
underscores
promise
disease
treatment
highlights
further
research
optimize
utilization.
Язык: Английский