Bioinspired Bimetallic Ions Functionalized MOF SAzyme Nanocomposites for Synergistic Ferroptosis/Cuproptosis-Enhanced Immune Checkpoint Therapy DOI Creative Commons

Linjiao Yang,

Mengmeng Pan,

Haofan Hu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

Abstract Immune checkpoint blockade (ICB) generates sustained responses in immunogenic cancers, but its effectiveness is limited tumors lacking immune activity. Here, we construct a bioinspired bimetallic ions functionalized nanoscale metal-organic framework (NMOF) single-atom nanozyme (SAzyme) loaded with doxorubicin (Dox) (NMOF-Fe/Cu-Dox nanocomposite) to effectively trigger anti-tumor while addressing the immunosuppressive tumor microenvironment (TME). The NMOF-Fe/Cu-Dox nanocomposite has been demonstrated efficiently reverse TME by generating reactive oxygen species and oxidizing glutathione. Camouflaging nanocomposites cancer cell membrane (NMOF-Fe/Cu-Dox@M) enables navigation region through homologous targeting. highly efficient uptaken cells selectively induced synergistic ferroptosis cuproptosis these cells. Furthermore, vitro vivo experiments demonstrate that can polarize tumor-associated macrophages (TAMs) towards anti-tumoral M1 phenotype significantly diminish pro-tumoral M2 phenotype. We find NMOF-Fe/Cu-Dox@M could induce of macrophages, no effect macrophages. In addition, significant increase infiltrating CD8 + T cells, remarkable decrease CD4 regulatory were observed. These findings suggested modulate TME, enhance tumoricidal immunity elevate therapeutic efficiency ICB. Moreover, combination αPD-1 eradicated hepatocellular carcinoma , outperforming use either or alone. summary, our study presents strategy leverages coordinated ICB, underscoring promise combined chemoimmunotherapy.

Язык: Английский

Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy DOI
Yuanying Yang, Chen Dong, Xuehua Ma

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Язык: Английский

Процитировано

2
Redox-manipulating nanocarriers for anticancer drug delivery: a systematic review DOI Creative Commons
Xuan Meng,

Yongli Shen,

Huanyu Zhao

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 28, 2024

Язык: Английский

Процитировано

15
Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy DOI

Qiuhong Ouyang,

Ying Zhao, Kunyao Xu

и другие.

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Июль 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Язык: Английский

Процитировано

14
The Role of Copper Ions in Mediating the Anti‐Cancer Effects Using Nanomaterials DOI Open Access

Irfan Mehmud,

Song Wu, Shaohua Zhang

и другие.

Advanced Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Copper plays a pivotal role in human physiology, particularly oncology, acting both as facilitator of progression and also potential avenue for advanced therapeutic approaches. Maintaining copper homeostasis is crucial. The dysregulation implicated tumor growth through its involvement critical processes angiogenesis, proliferation, metastasis. elevation level the microenvironment (TME) activates oncogenic pathways to drive neovascularization sustained malignancies. However, same reliance on offers unique weakness that can be leveraged innovative interventions. recent advances nanomedicine enable synthesis nanostructures help modulate with precision offering multifaceted approaches copper‐based cancer therapy controlled release mechanism, optimized structures induce cuproptosis, selective eradication cells minimum systemic toxicity. This review explores dual biology, emphasizing contribution tumors emerging application targeted therapy. highlights harnessing therapies their transformative from bench bed side novel, highly effective, clinical safety.

Язык: Английский

Процитировано

1
Single-atom–doped piezocatalyst induces copper-free cuproptosis in tumor therapy DOI Creative Commons
M. Zhang, Xinran Song, Yu Qin

и другие.

Science Advances, Год журнала: 2025, Номер 11(7)

Опубликована: Фев. 14, 2025

Cuproptosis, a distinct cell death pathway, has been integrated into nanomedicine for disease theranostics. However, current nanosystems inducing cuproptosis rely on exogenous toxic copper ions, limiting the scope of biomaterials. Developing nanoplatforms that induce without holds substantial promise. Here, we engineered two-dimensional iron (Fe) single-atom–doped molybdenum disulfide (MoS 2 ) piezocatalyst (Fe-MoS tumor therapy. Incorporating single Fe atoms enhances MoS piezoelectric polarization via charge redistribution and modulates Mo oxidation states, enabling multifaceted enzymatic activities, including peroxidase-, glutathione oxidase–, oxidase-, catalase-like activities. Upon ultrasound stimulation, Fe-MoS nanocatalyst generates reactive oxygen species depletes synergistic piezocatalytic enzyocatalytic effects, disrupting ion homeostasis cuproptosis, concurrently triggering ferroptosis ferritinophagy, which collectively suppression. This study represents first paradigm to introduce copper-free initiating substantially advancing applications in

Язык: Английский

Процитировано

1
Zweifach–Fung Microfluidic Device for Efficient Microparticle Separation: Cost-Effective Fabrication Using CO2 Laser-Ablated PMMA DOI Creative Commons
Cristian F. Rodríguez,

Mateo Báez-Suárez,

Carolina Muñoz-Camargo

и другие.

Micromachines, Год журнала: 2024, Номер 15(7), С. 932 - 932

Опубликована: Июль 22, 2024

Microfluidic separators play a pivotal role in the biomedical and chemical industries by enabling precise fluid manipulations. Traditional fabrication of these devices typically requires costly cleanroom facilities, which limits their broader application. This study introduces novel microfluidic device that leverages passive Zweifach–Fung principle to overcome financial barriers. Through Lagrangian computational simulations, we optimized an eleven-channel configuration achieved perfect 100% recall rate for particles following specified normal distribution. Experimental evaluations determined 2 mL/h as optimal total flow (TFR), under showcased exceptional performance enhancements precision micrometer-sized particles, achieving overall accuracy 94% ± 3%. Fabricated using cost-effective, non-cleanroom method, this approach represents significant shift from conventional practices, dramatically reducing production costs while maintaining high operational efficacy. The cost each chip is less than USD 0.90 cents manufacturing process takes only 15 min. development not makes technology more accessible but also sets new standard future advancements field.

Язык: Английский

Процитировано

7
Copper-Based Nanomedicines for Cuproptosis-Mediated Effective Cancer Treatment DOI Creative Commons

Dahye Noh,

Hokyung Lee,

Sangmin Lee

и другие.

Biomaterials Research, Год журнала: 2024, Номер 28

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

5
Spatiotemporal Delivery of Dual Nanobodies by Engineered Probiotics to Reverse Tumor Immunosuppression via Targeting Tumor-Derived Exosomes DOI

Shurong Qin,

Yuta Liu,

Guanzhong He

и другие.

ACS Nano, Год журнала: 2024, Номер 18(39), С. 26858 - 26871

Опубликована: Сен. 23, 2024

The anti-PD-L1 and its bispecific antibodies have exhibited durable antitumor immunity but still elicit immunosuppression mainly caused by tumor-derived exosomes (TDEs), leading to difficulty in clinical transformation. Herein, engineered

Язык: Английский

Процитировано

4
Modulating the Electronic Structure of MnNi2S3 Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen‐Immunotherapy DOI
Jingrui Li, Gang Wang,

Zhaoyu Wen

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Hydrogen (H 2 ) therapy has demonstrated antitumor effect, but the therapeutic efficacy is restricted by low solubility and nontarget delivery of H . Electrolysis O electrocatalysts sustainably releases enormous amounts inspires precise for tumor therapy. Herein, manganese‐doped Ni S 3 nanoelectrodes (MnNi NEs) are designed electrocatalytic activation immunity to effectively potentiate ‐immunotherapy. atoms featuring empty 3d orbitals reduce initial energy barrier hydrogen evolution reaction (HER) promoting adsorption O. Moreover, Mn with different electronegativity modulate electronic structure facilitate desorption generated , thus enhancing HER activity MnNi NEs. Based on high activity, controllable (EHT) achieved in a voltage‐dependent manner. Mechanistically, NE‐mediated EHT induces mitochondrial dysfunction oxidative stress, which subsequently activates pyroptosis through typical ROS/caspase‐1/GSDMD signaling pathway. Furthermore, enhances infiltration CD8 + T lymphocytes into tumors reverses immunosuppressive microenvironment. This work demonstrates an electrocatalyst synergistic gas‐immunotherapy, may spark electrocatalyst‐based strategies.

Язык: Английский

Процитировано

4
Catalytic Biomaterials‐Activated In Situ Chemical Reactions: Strategic Modulation and Enhanced Disease Treatment DOI Open Access
Huijing Wang, Wenjin He, Jing Liao

и другие.

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Abstract Chemical reactions underpin biological processes, and imbalances in critical biochemical pathways within organisms can lead to the onset of severe diseases. Within this context, emerging field “Nanocatalytic Medicine” leverages nanomaterials as catalysts modulate fundamental chemical specific microenvironments This approach is designed facilitate targeted synthesis localized accumulation therapeutic agents, thus enhancing treatment efficacy precision while simultaneously reducing systemic side effects. The effectiveness these nanocatalytic strategies critically hinges on a profound understanding kinetics intricate interplay particular pathological ensure effective catalytic actions. review methodically explores situ their associated biomaterials, emphasizing regulatory that control responses. Furthermore, discussion encapsulates crucial elements‐reactants, catalysts, reaction conditions/environments‐necessary for optimizing thermodynamics reactions, rigorously addressing both biophysical dimensions disease enhance outcomes. It seeks clarify mechanisms underpinning biomaterials evaluate potential revolutionize across various conditions.

Язык: Английский

Процитировано

4