Inflammation-targeting nanoparticles impede neutrophil infiltration and scavenge ROS for acute lung injury alleviation

International Journal of Pharmaceutics, Год журнала: 2025, Номер 673, С. 125359 - 125359

Опубликована: Фев. 13, 2025

Язык: Английский

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The potential therapeutic effect of human umbilical cord mesenchymal stem cell-derived exosomes in bronchopulmonary dysplasia

Life Sciences, Год журнала: 2024, Номер 357, С. 123047 - 123047

Опубликована: Сен. 12, 2024

Язык: Английский

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Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles

Chemical & Biomedical Imaging, Год журнала: 2025, Номер 3(3), С. 137 - 168

Опубликована: Фев. 2, 2025

Mesenchymal stem-cell-derived extracellular vesicles (MSC-EVs) are nanoscale lipid bilayer secreted by mesenchymal stem cells. They inherit the parent cell's attributes, facilitating tissue repair and regeneration, promoting angiogenesis, modulating immune response, while offering advantages like reduced immunogenicity, straightforward administration, enhanced stability for long-term storage. These characteristics elevate MSC-EVs as highly promising in cell-free therapy with notable clinical potential. It is critical to delve into their pharmacokinetics thoroughly elucidate intracellular vivo trajectories. A detailed summary evaluation of existing tracing strategies needed establish standardized protocols. Here, we have summarized anticipated research progress various biomedical imaging techniques, including fluorescence imaging, bioluminescence nuclear (PET, SPECT), tomographic (CT, MRI), photoacoustic imaging. The challenges prospects MSC-EV strategies, particular emphasis on translation, been analyzed, solutions proposed.

Язык: Английский

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Extracellular vesicles as natural nanocarriers: From in vitro engineering to in situ generation in cancer therapy

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161653 - 161653

Опубликована: Март 1, 2025

Язык: Английский

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NAC-Grafted ROS-Scavenging Polymer Nanoparticles for Modulation of Acute Lung Injury Microenvironment In Vivo

Biomacromolecules, Год журнала: 2024, Номер 26(1), С. 528 - 540

Опубликована: Дек. 27, 2024

N-Acetyl cysteine (NAC) is an essential molecule that boosts acute lung injury (ALI) defense via its direct antioxidant capability. Nevertheless, the therapeutic use of NAC limited due to poor bioavailability and short half-life. In this study, was grafted polyurethane consisting poly(propylene fumarate), poly(thioketal), 1,6-hexamethylene diisocyanate (PFTU) reduce excessive oxidative stress inflammatory factors in ALI. The NAC-grafted polymer nanoparticles (NPT@NPs) were prepared as a drug delivery system, which could effectively scavenge free radicals inflammation vitro. administration NPT@NPs exhibited notable efficacy ameliorating pulmonary edema, attenuating presence cells, suppressing myeloperoxidase expression, diminishing levels pro-inflammatory cytokines, reversing cell apoptosis ALI model induced by lipopolysaccharide (LPS). demonstrated significantly better compared mitigating deleterious effects LPS on tissue, thereby providing more effective protection against inflammation.

Язык: Английский

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Exosomes of different cellular origins: prospects and challenges in the treatment of acute lung injury after burns

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Дек. 14, 2024

The unique properties of exosomes and their applications in ALI, particularly the delivery diverse drug molecules, are summarized. Additionally, current challenges use treatment ALI proposed.

Язык: Английский

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