Exosomes of different cellular origins: prospects and challenges in the treatment of acute lung injury after burns DOI
Shuo Zhang, Xinyu Zhao, Yang Lv

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 14, 2024

The unique properties of exosomes and their applications in ALI, particularly the delivery diverse drug molecules, are summarized. Additionally, current challenges use treatment ALI proposed.

Language: Английский

Inflammation-targeting nanoparticles impede neutrophil infiltration and scavenge ROS for acute lung injury alleviation DOI
Ling Ma, Fang Chen, Shuang Chen

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 673, P. 125359 - 125359

Published: Feb. 13, 2025

Language: Английский

Citations

1
The potential therapeutic effect of human umbilical cord mesenchymal stem cell-derived exosomes in bronchopulmonary dysplasia DOI

Tianyu Cheng,

Min Mao, Yang Liu

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 357, P. 123047 - 123047

Published: Sept. 12, 2024

Language: Английский

Citations

5
Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles DOI Creative Commons
Jingqi Li, Zhaoyu Wang,

Yongchun Wei

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: 3(3), P. 137 - 168

Published: Feb. 2, 2025

Mesenchymal stem-cell-derived extracellular vesicles (MSC-EVs) are nanoscale lipid bilayer secreted by mesenchymal stem cells. They inherit the parent cell's attributes, facilitating tissue repair and regeneration, promoting angiogenesis, modulating immune response, while offering advantages like reduced immunogenicity, straightforward administration, enhanced stability for long-term storage. These characteristics elevate MSC-EVs as highly promising in cell-free therapy with notable clinical potential. It is critical to delve into their pharmacokinetics thoroughly elucidate intracellular vivo trajectories. A detailed summary evaluation of existing tracing strategies needed establish standardized protocols. Here, we have summarized anticipated research progress various biomedical imaging techniques, including fluorescence imaging, bioluminescence nuclear (PET, SPECT), tomographic (CT, MRI), photoacoustic imaging. The challenges prospects MSC-EV strategies, particular emphasis on translation, been analyzed, solutions proposed.

Language: Английский

Citations

0
Extracellular vesicles as natural nanocarriers: From in vitro engineering to in situ generation in cancer therapy DOI
Teng Zhang,

Zimai Liu,

Yuanyuan Wei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161653 - 161653

Published: March 1, 2025

Language: Английский

Citations

0
NAC-Grafted ROS-Scavenging Polymer Nanoparticles for Modulation of Acute Lung Injury Microenvironment In Vivo DOI
Wali Muhammad, Min Liang,

Beiduo Wang

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 528 - 540

Published: Dec. 27, 2024

N-Acetyl cysteine (NAC) is an essential molecule that boosts acute lung injury (ALI) defense via its direct antioxidant capability. Nevertheless, the therapeutic use of NAC limited due to poor bioavailability and short half-life. In this study, was grafted polyurethane consisting poly(propylene fumarate), poly(thioketal), 1,6-hexamethylene diisocyanate (PFTU) reduce excessive oxidative stress inflammatory factors in ALI. The NAC-grafted polymer nanoparticles (NPT@NPs) were prepared as a drug delivery system, which could effectively scavenge free radicals inflammation vitro. administration NPT@NPs exhibited notable efficacy ameliorating pulmonary edema, attenuating presence cells, suppressing myeloperoxidase expression, diminishing levels pro-inflammatory cytokines, reversing cell apoptosis ALI model induced by lipopolysaccharide (LPS). demonstrated significantly better compared mitigating deleterious effects LPS on tissue, thereby providing more effective protection against inflammation.

Language: Английский

Citations

1
Exosomes of different cellular origins: prospects and challenges in the treatment of acute lung injury after burns DOI
Shuo Zhang, Xinyu Zhao, Yang Lv

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 14, 2024

The unique properties of exosomes and their applications in ALI, particularly the delivery diverse drug molecules, are summarized. Additionally, current challenges use treatment ALI proposed.

Language: Английский

Citations

0