Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles DOI Creative Commons

Tenesha Connor,

Hemal Weerasinghe, Justin D. Lathia

и другие.

Photonics, Год журнала: 2024, Номер 12(1), С. 3 - 3

Опубликована: Дек. 24, 2024

Quantum dots (QDs) have emerged as promising tools in advancing multiphoton microscopy (MPM) for deep brain imaging, addressing long-standing challenges resolution, penetration depth, and light–tissue interactions. MPM, which relies on nonlinear photon absorption, enables fluorescence imaging within defined volumes, effectively reducing background noise photobleaching. However, achieving greater depths remains limited by light scattering compounded the need balanced laser power to avoid tissue damage. QDs, nanoscale semiconductor particles with unique optical properties, offer substantial advantages over traditional fluorophores, including high quantum yields, large absorption cross-sections, superior photostability, tunable emission spectra. These properties enhance signal ratio at increased reduce effects, making QDs ideal subcortical regions like hippocampus without extensive microscope modifications. Studies demonstrated capability of achieve up 2100 μm, far exceeding that conventional fluorophores. Beyond structural facilitate functional applications, such high-resolution tracking hemodynamic responses neural activity, supporting investigations neuronal dynamics blood flow vivo. Their stability long-term, targeted drug delivery photodynamic therapy, presenting potential therapeutic applications treating tumors, Alzheimer’s disease, traumatic injury. This review highlights impact their effectiveness overcoming attenuation tissue, expanding role diagnosing neurological disorders, positioning them transformative agents both intervention.

Язык: Английский

Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models DOI Creative Commons
Yiqun Ma, Shujie Xia,

Annan Hu

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 19, 2025

Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral emerges as a promising modality due to its high spatial resolution and signal stability. However, clinical application in vivo limited by the inherently weak scattering signal. To address this challenge, we developed novel strategy that integrates two enhancement mechanisms into single contrast agent. This agent exploits synergistic effects of an anisotropic gold nanorod polypyrrole-polydopamine hybrid, resulting substantial amplification signals. Consequently, enables clear delineation malignant tissues both orthotopic subcutaneous tumor models. Beyond capability, also facilitates photothermal ablation, providing long-term solution suppressing recurrence. study systematically evaluates performance synthesized agents across different models highlights role optimizing aspect ratio imaging. By offering dual-function agent, research advances potential intraoperative applications translation.

Язык: Английский

Процитировано

0
Nanomaterial Technologies for Precision Diagnosis and Treatment of Brain Hemorrhage DOI
Peisen Zhang,

Y. Ran,

Lei Han

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123269 - 123269

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Advances in spectroscopic detection of traumatic brain injury biomarkers: Potential for diagnostic applications DOI
Yowhan Son,

Moon‐Young Jeong,

Jong Min Lim

и другие.

Applied Spectroscopy Reviews, Год журнала: 2025, Номер unknown, С. 1 - 30

Опубликована: Апрель 4, 2025

Язык: Английский

Процитировано

0
Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles DOI Creative Commons

Tenesha Connor,

Hemal Weerasinghe, Justin D. Lathia

и другие.

Photonics, Год журнала: 2024, Номер 12(1), С. 3 - 3

Опубликована: Дек. 24, 2024

Quantum dots (QDs) have emerged as promising tools in advancing multiphoton microscopy (MPM) for deep brain imaging, addressing long-standing challenges resolution, penetration depth, and light–tissue interactions. MPM, which relies on nonlinear photon absorption, enables fluorescence imaging within defined volumes, effectively reducing background noise photobleaching. However, achieving greater depths remains limited by light scattering compounded the need balanced laser power to avoid tissue damage. QDs, nanoscale semiconductor particles with unique optical properties, offer substantial advantages over traditional fluorophores, including high quantum yields, large absorption cross-sections, superior photostability, tunable emission spectra. These properties enhance signal ratio at increased reduce effects, making QDs ideal subcortical regions like hippocampus without extensive microscope modifications. Studies demonstrated capability of achieve up 2100 μm, far exceeding that conventional fluorophores. Beyond structural facilitate functional applications, such high-resolution tracking hemodynamic responses neural activity, supporting investigations neuronal dynamics blood flow vivo. Their stability long-term, targeted drug delivery photodynamic therapy, presenting potential therapeutic applications treating tumors, Alzheimer’s disease, traumatic injury. This review highlights impact their effectiveness overcoming attenuation tissue, expanding role diagnosing neurological disorders, positioning them transformative agents both intervention.

Язык: Английский

Процитировано

0