Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles DOI Creative Commons

Tenesha Connor,

Hemal Weerasinghe, Justin D. Lathia

et al.

Photonics, Journal Year: 2024, Volume and Issue: 12(1), P. 3 - 3

Published: Dec. 24, 2024

Quantum dots (QDs) have emerged as promising tools in advancing multiphoton microscopy (MPM) for deep brain imaging, addressing long-standing challenges resolution, penetration depth, and light–tissue interactions. MPM, which relies on nonlinear photon absorption, enables fluorescence imaging within defined volumes, effectively reducing background noise photobleaching. However, achieving greater depths remains limited by light scattering compounded the need balanced laser power to avoid tissue damage. QDs, nanoscale semiconductor particles with unique optical properties, offer substantial advantages over traditional fluorophores, including high quantum yields, large absorption cross-sections, superior photostability, tunable emission spectra. These properties enhance signal ratio at increased reduce effects, making QDs ideal subcortical regions like hippocampus without extensive microscope modifications. Studies demonstrated capability of achieve up 2100 μm, far exceeding that conventional fluorophores. Beyond structural facilitate functional applications, such high-resolution tracking hemodynamic responses neural activity, supporting investigations neuronal dynamics blood flow vivo. Their stability long-term, targeted drug delivery photodynamic therapy, presenting potential therapeutic applications treating tumors, Alzheimer’s disease, traumatic injury. This review highlights impact their effectiveness overcoming attenuation tissue, expanding role diagnosing neurological disorders, positioning them transformative agents both intervention.

Language: Английский

Ultrabright contrast agents with synergistic Raman enhancements for precise intraoperative imaging and photothermal ablation of orthotopic tumor models DOI Creative Commons
Yiqun Ma, Shujie Xia,

Annan Hu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 19, 2025

Intraoperative imaging is critical for achieving precise cancer resection. Among available techniques, Raman spectral emerges as a promising modality due to its high spatial resolution and signal stability. However, clinical application in vivo limited by the inherently weak scattering signal. To address this challenge, we developed novel strategy that integrates two enhancement mechanisms into single contrast agent. This agent exploits synergistic effects of an anisotropic gold nanorod polypyrrole-polydopamine hybrid, resulting substantial amplification signals. Consequently, enables clear delineation malignant tissues both orthotopic subcutaneous tumor models. Beyond capability, also facilitates photothermal ablation, providing long-term solution suppressing recurrence. study systematically evaluates performance synthesized agents across different models highlights role optimizing aspect ratio imaging. By offering dual-function agent, research advances potential intraoperative applications translation.

Language: Английский

Citations

3
Advances in spectroscopic detection of traumatic brain injury biomarkers: Potential for diagnostic applications DOI
Yowhan Son,

Moon‐Young Jeong,

Jong Min Lim

et al.

Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 30

Published: April 4, 2025

Language: Английский

Citations

1
Nanomaterial Technologies for Precision Diagnosis and Treatment of Brain Hemorrhage DOI
Peisen Zhang,

Y. Ran,

Lei Han

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123269 - 123269

Published: March 1, 2025

Language: Английский

Citations

0
Near‐Infrared Excitation/Emission Metal‐Free Probe with Frequency Up‐Conversion for Dual‐Modality Imaging DOI

Yong Guo,

Hao Li, Luwei Wang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract A multimodal fluorescent probe with near‐infrared excitation/emission, exceptional photostability, and superior biocompatibility is essential for exploring complex life science challenges significant diseases. Carbon dots (CDs), due to their rich optical properties favorable biocompatibility, have garnered growing interest in the field of bioimaging. Here, it demonstrated first time that nitrogen‐doped CDs (N‐CDs) exhibit frequency up‐conversion luminescence (FUCL) excitation (λ = 740–820 nm) emission 723 S(NIR) region. These N‐CDs also possess outstanding ability target biomolecules, such as nucleic acids. Utilizing a self‐developed imaging microscope, probes enable multifunctional imaging, including visualization mitosis process corresponding changes chromosome diameter onion root tip cells; dual‐modality (fluorescence intensity lifetime) multicolor mouse kidney tissue structure; monitoring cortical vascular distribution blood flow dynamics mice.

Language: Английский

Citations

0
Traumatic Brain Injury: Novel Experimental Approaches and Treatment Possibilities DOI Creative Commons
Kristina Pilipović, Tamara Janković,

Jelena Rajič Bumber

et al.

Life, Journal Year: 2025, Volume and Issue: 15(6), P. 884 - 884

Published: May 30, 2025

Traumatic brain injury (TBI) remains a critical global health issue with limited effective treatments. Traditional care of TBI patients focuses on stabilization and symptom management without regenerating damaged tissue. In this review, we analyze the current state treatment TBI, focus novel therapeutic approaches aimed at reducing secondary promoting recovery. There are few innovative strategies that break away from traditional, biological target-focused approaches. Precision medicine includes personalized treatments based biomarkers, genetics, advanced imaging, artificial intelligence tools for prognosis monitoring. Stem cell therapies used to repair tissue, regulate immune responses, support neural regeneration, ongoing development in gene-enhanced Nanomedicine uses nanomaterials targeted drug delivery, neuroprotection, diagnostics by crossing blood–brain barrier. Brain–machine interfaces enable brain-device communication restore lost motor or neurological functions, while virtual rehabilitation neuromodulation use augmented reality as well stimulation techniques improve outcomes. While these show great potential, most still require more clinical testing confirm safety effectiveness. The future therapy looks promising, likely transform care.

Language: Английский

Citations

0
Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles DOI Creative Commons

Tenesha Connor,

Hemal Weerasinghe, Justin D. Lathia

et al.

Photonics, Journal Year: 2024, Volume and Issue: 12(1), P. 3 - 3

Published: Dec. 24, 2024

Quantum dots (QDs) have emerged as promising tools in advancing multiphoton microscopy (MPM) for deep brain imaging, addressing long-standing challenges resolution, penetration depth, and light–tissue interactions. MPM, which relies on nonlinear photon absorption, enables fluorescence imaging within defined volumes, effectively reducing background noise photobleaching. However, achieving greater depths remains limited by light scattering compounded the need balanced laser power to avoid tissue damage. QDs, nanoscale semiconductor particles with unique optical properties, offer substantial advantages over traditional fluorophores, including high quantum yields, large absorption cross-sections, superior photostability, tunable emission spectra. These properties enhance signal ratio at increased reduce effects, making QDs ideal subcortical regions like hippocampus without extensive microscope modifications. Studies demonstrated capability of achieve up 2100 μm, far exceeding that conventional fluorophores. Beyond structural facilitate functional applications, such high-resolution tracking hemodynamic responses neural activity, supporting investigations neuronal dynamics blood flow vivo. Their stability long-term, targeted drug delivery photodynamic therapy, presenting potential therapeutic applications treating tumors, Alzheimer’s disease, traumatic injury. This review highlights impact their effectiveness overcoming attenuation tissue, expanding role diagnosing neurological disorders, positioning them transformative agents both intervention.

Language: Английский

Citations

0