Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
The
emerged
apoptosis/ferroptosis
synergistic
platinum-based
therapy
has
attracted
a
lot
of
attention
but
is
far
from
clinic
use
due
to
high
systemic
toxicity.
Herein,
series
novel
precise
carrier-free
self-assembled
platinum(IV)
nanoparticles
with
lipid
regulation
effect
named
FSPNPs
(5NPs–8NPs)
were
constructed
via
connecting
fenofibrate
acid
(FA)
cisplatin
or
oxaliplatin-derived
platinum(IV)-intermediates
disulfide
bonds.
can
be
stimulated
by
high-glutathione/ascorbic
and
acidity
environment
produce
an
"explosion-like"
cascade
release
process.
Cell-activity
showed
precision
FSPNPs,
which
accumulated
more
in
tumor
cells
inhibited
cell
proliferation.
Especially,
5NPs
have
higher
selectivity
than
cisplatin.
downregulated
glutathione/glutathione
peroxidase
4,
increased
reactive
oxygen
species/lipid
peroxidation/malondialdehyde,
induced
DNA
damage/S-phase
arrest,
regulated
p53/Bcl-2/Bax
trigger
the
hybrid
pathway.
released
FA
derivates
docked
into
peroxisome
proliferator-activated
receptor
α
activating
cholesterol
metabolism
destroy
membrane
integrity.
also
good
biocompatibility
superior
antitumor
activity
no
observable
tissue
damage.
Gene
therapy
and
sonodynamic
therapy,
as
emerging
treatment
methods,
have
great
potential
in
cancer
treatment.
However,
there
are
significant
challenges
the
vivo
delivery
of
genes
sonosensitizers
during
process,
which
ultimately
affects
therapeutic
outcome.
In
this
study,
an
ultrasound-sensitive
targeted
liposome
nanoparticle
system
(MLip
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
20(2), С. 101016 - 101016
Опубликована: Янв. 5, 2025
Mitochondria
provides
adenosine
triphosphate
for
multiple
vital
movements
to
ensure
tumor
cell
proliferation.
Compared
the
broadly
used
method
of
inducing
DNA
replication
arrest
kill
cancer,
mitochondria
damage
cause
energy
shortage
is
quite
promising
as
it
can
inhibit
bioactivities,
increase
intracellular
accumulation
toxic
drugs,
eventually
sensitize
chemotherapy
and
even
reverse
drug
resistance.
Breaking
balance
glutathione
(GSH)
reactive
oxygen
species
(ROS)
contents
have
been
proven
efficient
in
destroying
respectively.
Herein,
apigenin,
a
GSH
efflux
reagent,
2'-deoxy-5-fluorouridine
5'-monophosphate
sodium
salt
(FdUMP)
that
could
induce
ROS
were
co-delivered
by
constructed
lipid
nanoparticles,
noted
Lip@AF.
An
immune-checkpoint
inhibition
reagent
CD276
antibody
was
modified
onto
surface
Lip@AF
with
high
reaction
specificity
(noted
αCD276-Lip@AF)
enhance
recognition
immune
cells
tumor.
Results
showed
redox
destroyed,
leading
severe
injury
membrane.
Furthermore,
synergistic
DNA/RNA
caused
inhibiting
function
thymidylate
synthase
observed.
Eventually,
significantly
enhanced
cytotoxicity
achieved
combining
mechanisms
including
ferroptosis,
apoptosis
pyroptosis.
In
vivo,
strengthen
growth
αCD276-Lip@AF
biosafety,
providing
new
sights
enhancing
sensitiveness
achieving
high-performance
chemo-immunotherapy.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Treatment
for
hepatocellular
carcinoma
(HCC)
may
be
improved
with
ferroptosis,
a
regulated
form
of
cell
death.
However,
the
sensitivity
HCC
to
ferroptosis
was
strongly
limited
by
lactic
acid.
In
this
study,
platelet
membrane
(PM)-engineered
nanoparticle
loaded
erastin,
superparamagnetic
iron
oxide
nanoparticles
(SPIO)
and
lactate
oxidase
(LOX)
(termed
PM@ESL
NPs)
designed
magnetic
resonance
imaging
(MRI)-guided
enhanced
ferroptosis-immunotherapy
HCC.
It
found
that
NPs
could
actively
accumulate
into
tumor
due
tumor-homing
ability
PM.
Subsequently,
effectively
enhance
removing
acid
in
tumor.
The
removal
also
produces
hydrogen
peroxide
(H2O2),
which
therefore
converted
cytotoxic
hydroxyl
radicals
reaction
H2O2
Fe2+/Fe3+
released
from
SPIO.
Due
combined
chemodynamic
therapy
(CDT),
NPS
showed
strong
induce
immunogenic
death
(ICD),
suppress
growth
metastasis
when
αPD-L1
immunotherapy.
Furthermore,
incorporation
SPIO
endows
an
outstanding
MRI-T2
monitoring
capability
treatment.
conclusion,
study
introduces
pioneering
MRI-guided
approach
enhances
tumors
synergistically
improves
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 19, 2024
Radiotherapy
(RT)
is
a
primary
clinical
approach
for
cancer
treatment,
but
its
efficacy
often
hindered
by
various
challenges,
especially
radiation
resistance,
which
greatly
compromises
the
therapeutic
effectiveness
of
RT.
Mitochondria,
central
to
cellular
energy
metabolism
and
regulation
cell
death,
play
critical
role
in
mechanisms
radioresistance.
In
this
context,
cuproptosis,
novel
copper-induced
mitochondria-respiratory-dependent
death
pathway,
offers
promising
avenue
radiosensitization.
study,
an
innovative
theranostic
nanoplatform
was
designed
induce
cuproptosis
synergy
with
low-dose
therapy
(LDRT,
i.e.,
0.5–2
Gy)
treatment
situ
hepatocellular
carcinoma
(HCC).
This
aims
reverse
hypoxic
tumor
microenvironment,
promoting
shift
from
glycolysis
oxidative
phosphorylation
(OXPHOS),
thereby
enhancing
sensitivity
cuproptosis.
Concurrently,
Fenton-like
reaction
ensures
sustained
supply
copper
depletion
glutathione
(GSH),
inducing
disrupting
mitochondrial
function,
interrupting
supply.
strategy
effectively
overcomes
radioresistance
enhances
against
tumors.
conclusion,
study
elucidates
intricate
interactions
among
hypoxia
reversal,
metabolic
reprogramming,
radiosensitization,
particularly
context
treating
carcinoma,
providing
paradigm
radiotherapy.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2024,
Номер
16(6)
Опубликована: Ноя. 1, 2024
ABSTRACT
Ferroptosis
is
a
lipid
peroxidation‐driven
cell
death
route
and
has
attracted
enormous
interest
for
cancer
therapy.
Distinct
from
other
forms
of
regulated
death,
its
process
involved
with
multiple
metabolic
pathways
including
lipids,
bioenergetics,
iron,
so
on,
which
influence
ferroptosis
sensitivity
communication
the
immune
cells
in
tumor
microenvironment.
Development
novel
technologies
harnessing
ferroptosis‐associated
regulatory
network
would
profoundly
improve
our
understanding
responses
enhance
efficacy
ferroptosis‐dependent
immunotherapy.
Interestingly,
recent
advances
bio‐derived
material‐based
therapeutic
platforms
offer
opportunities
to
therapeutically
modulate
metabolism
through
situ
delivery
molecular
or
material
cues,
not
only
allows
tumor‐specific
elicitation
but
also
holds
promise
maximize
their
immunostimulatory
impact.
In
this
review,
we
will
first
dissect
crosstalk
between
impact
on
regulation
microenvironment,
followed
by
comprehensive
analysis
progress
biomaterial‐based
strategies
evoking
ferroptosis‐mediated
antitumor
immunity.
A
perspective
section
provided
discuss
challenges
metabolism‐regulating
biomaterials
ferroptosis‐immunotherapy.
We
envision
that
review
may
provide
new
insights
improving
immunotherapeutic
clinic.
Iron
is
an
important
microelement
in
human
and
microbial
life
activities.
During
the
pathophysiological
process
of
sepsis,
iron
metabolism
changes
body
undergoes
a
series
to
fight
infection.
Meanwhile,
alterations
during
sepsis
lead
development
some
diseases,
such
as
transfusion-induced
siderosis
anemia.
In
recent
years,
several
studies
have
demonstrated
use
iron-chelating
agents
infections,
new
antimicrobial
been
developed
using
“Trojan
horse”
siderophores
immunity.
addition,
iron-based
nanomaterials
drug
delivery
systems
for
gene
may
be
applied
treatment
future.
this
review,
we
describe
course
focusing
on
potential
sepsis.
