Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity DOI
Xu Guo, Xin Liang, Jiale Liu

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The emerged apoptosis/ferroptosis synergistic platinum-based therapy has attracted a lot of attention but is far from clinic use due to high systemic toxicity. Herein, series novel precise carrier-free self-assembled platinum(IV) nanoparticles with lipid regulation effect named FSPNPs (5NPs–8NPs) were constructed via connecting fenofibrate acid (FA) cisplatin or oxaliplatin-derived platinum(IV)-intermediates disulfide bonds. can be stimulated by high-glutathione/ascorbic and acidity environment produce an "explosion-like" cascade release process. Cell-activity showed precision FSPNPs, which accumulated more in tumor cells inhibited cell proliferation. Especially, 5NPs have higher selectivity than cisplatin. downregulated glutathione/glutathione peroxidase 4, increased reactive oxygen species/lipid peroxidation/malondialdehyde, induced DNA damage/S-phase arrest, regulated p53/Bcl-2/Bax trigger the hybrid pathway. released FA derivates docked into peroxisome proliferator-activated receptor α activating cholesterol metabolism destroy membrane integrity. also good biocompatibility superior antitumor activity no observable tissue damage.

Language: Английский

Ferroptosis and immunosenescence in colorectal cancer DOI
Yao Wang, Xinran Cao,

Chunbaixue Yang

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 156 - 165

Published: Oct. 16, 2024

Language: Английский

Citations

10
Mechanistic insights into ferroptosis and apoptosis pathways: Synergistic effects of multi-organ toxicity and transgenerational effects induced by co-exposure of epoxiconazole and aflatoxin B1 in zebrafish DOI Creative Commons

Ruike Wang,

Qi Zhang, Gang Chen

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Ultrasound‐Sensitive Targeted Liposomes as a Gene Delivery System for the Synergistic Treatment of Hepatocellular Carcinoma DOI

Guannan Wang,

Hongtong Lu,

Yong Pan

et al.

Small, Journal Year: 2024, Volume and Issue: 20(47)

Published: Aug. 27, 2024

Gene therapy and sonodynamic therapy, as emerging treatment methods, have great potential in cancer treatment. However, there are significant challenges the vivo delivery of genes sonosensitizers during process, which ultimately affects therapeutic outcome. In this study, an ultrasound-sensitive targeted liposome nanoparticle system (MLip

Language: Английский

Citations

4
Codelivery of apigenin, FdUMP and CD276 antibody synergistic inhibit colorectal cancer by ferroptosis-apoptosis-pyroptosis and CD276 blockade DOI Creative Commons
Weiran Cao, Xue Zhang, Jia‐Xuan Chen

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 20(2), P. 101016 - 101016

Published: Jan. 5, 2025

Mitochondria provides adenosine triphosphate for multiple vital movements to ensure tumor cell proliferation. Compared the broadly used method of inducing DNA replication arrest kill cancer, mitochondria damage cause energy shortage is quite promising as it can inhibit bioactivities, increase intracellular accumulation toxic drugs, eventually sensitize chemotherapy and even reverse drug resistance. Breaking balance glutathione (GSH) reactive oxygen species (ROS) contents have been proven efficient in destroying respectively. Herein, apigenin, a GSH efflux reagent, 2'-deoxy-5-fluorouridine 5'-monophosphate sodium salt (FdUMP) that could induce ROS were co-delivered by constructed lipid nanoparticles, noted Lip@AF. An immune-checkpoint inhibition reagent CD276 antibody was modified onto surface Lip@AF with high reaction specificity (noted αCD276-Lip@AF) enhance recognition immune cells tumor. Results showed redox destroyed, leading severe injury membrane. Furthermore, synergistic DNA/RNA caused inhibiting function thymidylate synthase observed. Eventually, significantly enhanced cytotoxicity achieved combining mechanisms including ferroptosis, apoptosis pyroptosis. In vivo, strengthen growth αCD276-Lip@AF biosafety, providing new sights enhancing sensitiveness achieving high-performance chemo-immunotherapy.

Language: Английский

Citations

0
Lactate-Fueled Theranostic Nanoplatforms for Enhanced MRI-Guided Ferroptosis Synergistic with Immunotherapy of Hepatocellular Carcinoma DOI
Xiaoxiao Chen, Feng Zhang,

Chenying Lu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Treatment for hepatocellular carcinoma (HCC) may be improved with ferroptosis, a regulated form of cell death. However, the sensitivity HCC to ferroptosis was strongly limited by lactic acid. In this study, platelet membrane (PM)-engineered nanoparticle loaded erastin, superparamagnetic iron oxide nanoparticles (SPIO) and lactate oxidase (LOX) (termed PM@ESL NPs) designed magnetic resonance imaging (MRI)-guided enhanced ferroptosis-immunotherapy HCC. It found that NPs could actively accumulate into tumor due tumor-homing ability PM. Subsequently, effectively enhance removing acid in tumor. The removal also produces hydrogen peroxide (H2O2), which therefore converted cytotoxic hydroxyl radicals reaction H2O2 Fe2+/Fe3+ released from SPIO. Due combined chemodynamic therapy (CDT), NPS showed strong induce immunogenic death (ICD), suppress growth metastasis when αPD-L1 immunotherapy. Furthermore, incorporation SPIO endows an outstanding MRI-T2 monitoring capability treatment. conclusion, study introduces pioneering MRI-guided approach enhances tumors synergistically improves

Language: Английский

Citations

0
Glutathione Metabolism in Ferroptosis and Cancer Therapy DOI
Xiangfei Xue, Manyuan Wang,

Jiangtao Cui

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217697 - 217697

Published: April 1, 2025

Language: Английский

Citations

0
Distinct Neurotoxic Mechanisms of Thallium and Lead: Calcium-Mediated Apoptosis and Iron-Induced Ferroptosis in Zebrafish at Environmental Concentrations DOI
Jian Liu,

Ai Guan,

Zihui Huo

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138288 - 138288

Published: April 1, 2025

Language: Английский

Citations

0
Synergistic enhancement of low-dose radiation therapy via cuproptosis and metabolic reprogramming for radiosensitization in in situ hepatocellular carcinoma DOI Creative Commons

Ni Shao,

Yongqing Yang,

Genwen Hu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

Radiotherapy (RT) is a primary clinical approach for cancer treatment, but its efficacy often hindered by various challenges, especially radiation resistance, which greatly compromises the therapeutic effectiveness of RT. Mitochondria, central to cellular energy metabolism and regulation cell death, play critical role in mechanisms radioresistance. In this context, cuproptosis, novel copper-induced mitochondria-respiratory-dependent death pathway, offers promising avenue radiosensitization. study, an innovative theranostic nanoplatform was designed induce cuproptosis synergy with low-dose therapy (LDRT, i.e., 0.5–2 Gy) treatment situ hepatocellular carcinoma (HCC). This aims reverse hypoxic tumor microenvironment, promoting shift from glycolysis oxidative phosphorylation (OXPHOS), thereby enhancing sensitivity cuproptosis. Concurrently, Fenton-like reaction ensures sustained supply copper depletion glutathione (GSH), inducing disrupting mitochondrial function, interrupting supply. strategy effectively overcomes radioresistance enhances against tumors. conclusion, study elucidates intricate interactions among hypoxia reversal, metabolic reprogramming, radiosensitization, particularly context treating carcinoma, providing paradigm radiotherapy.

Language: Английский

Citations

1
Biomaterial‐Mediated Metabolic Regulation of Ferroptosis for Cancer Immunotherapy DOI
Yingqi Liu, Dan Tao,

Menghuan Li

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(6)

Published: Nov. 1, 2024

ABSTRACT Ferroptosis is a lipid peroxidation‐driven cell death route and has attracted enormous interest for cancer therapy. Distinct from other forms of regulated death, its process involved with multiple metabolic pathways including lipids, bioenergetics, iron, so on, which influence ferroptosis sensitivity communication the immune cells in tumor microenvironment. Development novel technologies harnessing ferroptosis‐associated regulatory network would profoundly improve our understanding responses enhance efficacy ferroptosis‐dependent immunotherapy. Interestingly, recent advances bio‐derived material‐based therapeutic platforms offer opportunities to therapeutically modulate metabolism through situ delivery molecular or material cues, not only allows tumor‐specific elicitation but also holds promise maximize their immunostimulatory impact. In this review, we will first dissect crosstalk between impact on regulation microenvironment, followed by comprehensive analysis progress biomaterial‐based strategies evoking ferroptosis‐mediated antitumor immunity. A perspective section provided discuss challenges metabolism‐regulating biomaterials ferroptosis‐immunotherapy. We envision that review may provide new insights improving immunotherapeutic clinic.

Language: Английский

Citations

0
Role of iron in the treatment of sepsis DOI

Chen‐Zhi Zhang,

Zhiyao Fang,

Kaixuan Wang

et al.

Biointerphases, Journal Year: 2024, Volume and Issue: 19(6)

Published: Nov. 1, 2024

Iron is an important microelement in human and microbial life activities. During the pathophysiological process of sepsis, iron metabolism changes body undergoes a series to fight infection. Meanwhile, alterations during sepsis lead development some diseases, such as transfusion-induced siderosis anemia. In recent years, several studies have demonstrated use iron-chelating agents infections, new antimicrobial been developed using “Trojan horse” siderophores immunity. addition, iron-based nanomaterials drug delivery systems for gene may be applied treatment future. this review, we describe course focusing on potential sepsis.

Language: Английский

Citations

0