Hawthorn carbon dots: a novel therapeutic agent for modulating body weight and hepatic lipid profiles in high-fat diet-fed mice
Nanoscale,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Synthesis
of
HCD
(A)
and
intervention
on
obesity
in
high-fat
diet
mice
(B).
Язык: Английский
Obesity and Adipose-Derived Extracellular Vesicles: Implications for Metabolic Regulation and Disease
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 231 - 231
Опубликована: Фев. 5, 2025
Obesity,
a
global
epidemic,
is
major
risk
factor
for
chronic
diseases
such
as
type
2
diabetes,
cardiovascular
disorders,
and
metabolic
syndrome.
Adipose
tissue,
once
viewed
passive
fat
storage
site,
now
recognized
an
active
endocrine
organ
involved
in
regulation
inflammation.
In
obesity,
adipose
tissue
dysfunction
disrupts
balance,
leading
to
insulin
resistance
increased
production
of
adipose-derived
extracellular
vesicles
(AdEVs).
These
play
key
role
intercellular
communication
contribute
dysregulation,
affecting
organs
the
heart,
liver,
brain.
AdEVs
carry
bioactive
molecules,
including
microRNAs,
which
influence
inflammation,
sensitivity,
remodeling.
system,
can
promote
atherosclerosis
vascular
dysfunction,
while
those
derived
from
brown
offer
cardioprotective
effects.
exacerbate
complications
diabetic
cardiomyopathy
cognitive
decline.
Additionally,
are
implicated
liver
diseases,
fatty
disease,
by
transferring
inflammatory
molecules
lipotoxic
microRNAs
hepatocytes.
findings
highlight
obesity-related
disorders
their
promise
therapeutic
targets
related
diseases.
Язык: Английский
The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer
Nikola Odehnalová,
Viera Šandriková,
Róbert Hromádka
и другие.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 13, 2025
Exosomes,
nanosized
extracellular
vesicles
released
by
various
cell
types,
are
intensively
studied
for
the
diagnosis
and
treatment
of
cancer
neurodegenerative
diseases,
they
also
display
high
usability
in
regenerative
medicine.
Emphasizing
their
diagnostic
potential,
exosomes
serve
as
carriers
disease-specific
biomarkers,
enabling
non-invasive
early
detection
personalized
The
cargo
loading
with
therapeutic
agents
presents
an
innovative
strategy
targeted
drug
delivery,
minimizing
off-target
effects
optimizing
interventions.
In
medicine,
play
a
crucial
role
intercellular
communication,
facilitating
tissue
regeneration
through
transmission
bioactive
molecules.
While
acknowledging
existing
challenges
standardization
scalability,
ongoing
research
efforts
aim
to
refine
methodologies
address
regulatory
considerations.
summary,
this
review
underscores
transformative
potential
reshaping
landscape
medical
interventions,
particular
emphasis
on
cancer,
Язык: Английский
Advances in plant-derived vesicle like nanoparticles-based therapies for inflammatory diseases
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
unknown, С. 101052 - 101052
Опубликована: Апрель 1, 2025
Язык: Английский
Toward Clarity in Single Extracellular Vesicle Research: Defining the Field and Correcting Missteps
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Single
extracellular
vesicle
(EV)
research
holds
the
potential
to
revolutionize
our
understanding
of
cellular
communication
and
enable
breakthroughs
in
diagnostics
therapeutics.
However,
lack
a
clear,
consensus-driven
definition
single
EV
has
led
methodological
inconsistencies,
overgeneralized
interpretations,
and,
some
cases,
misleading
claims.
In
this
perspective,
we
propose
framework
for
defining
research,
critique
current
challenges
misconceptions
field,
discuss
its
implications
biomedical
applications.
We
argue
that
precise
experimental
design,
rigorous
validation,
interdisciplinary
collaboration
approaches
are
needed
establish
as
cornerstone
precision
medicine.
Язык: Английский