Toward Clarity in Single Extracellular Vesicle Research: Defining the Field and Correcting Missteps DOI Creative Commons
Yun Su,

Wanzhuo He,

Lei Zheng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Single extracellular vesicle (EV) research holds the potential to revolutionize our understanding of cellular communication and enable breakthroughs in diagnostics therapeutics. However, lack a clear, consensus-driven definition single EV has led methodological inconsistencies, overgeneralized interpretations, and, some cases, misleading claims. In this perspective, we propose framework for defining research, critique current challenges misconceptions field, discuss its implications biomedical applications. We argue that precise experimental design, rigorous validation, interdisciplinary collaboration approaches are needed establish as cornerstone precision medicine.

Language: Английский

Hawthorn carbon dots: a novel therapeutic agent for modulating body weight and hepatic lipid profiles in high-fat diet-fed mice DOI
Shuai Lin, Y. H. Zheng, Yi Xu

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Synthesis of HCD (A) and intervention on obesity in high-fat diet mice (B).

Language: Английский

Citations

0
Obesity and Adipose-Derived Extracellular Vesicles: Implications for Metabolic Regulation and Disease DOI Creative Commons

Michele Malaguarnera,

Omar Cauli, Andrea Cabrera‐Pastor

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 231 - 231

Published: Feb. 5, 2025

Obesity, a global epidemic, is major risk factor for chronic diseases such as type 2 diabetes, cardiovascular disorders, and metabolic syndrome. Adipose tissue, once viewed passive fat storage site, now recognized an active endocrine organ involved in regulation inflammation. In obesity, adipose tissue dysfunction disrupts balance, leading to insulin resistance increased production of adipose-derived extracellular vesicles (AdEVs). These play key role intercellular communication contribute dysregulation, affecting organs the heart, liver, brain. AdEVs carry bioactive molecules, including microRNAs, which influence inflammation, sensitivity, remodeling. system, can promote atherosclerosis vascular dysfunction, while those derived from brown offer cardioprotective effects. exacerbate complications diabetic cardiomyopathy cognitive decline. Additionally, are implicated liver diseases, fatty disease, by transferring inflammatory molecules lipotoxic microRNAs hepatocytes. findings highlight obesity-related disorders their promise therapeutic targets related diseases.

Language: Английский

Citations

0
The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer DOI Creative Commons

Nikola Odehnalová,

Viera Šandriková,

Róbert Hromádka

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 13, 2025

Exosomes, nanosized extracellular vesicles released by various cell types, are intensively studied for the diagnosis and treatment of cancer neurodegenerative diseases, they also display high usability in regenerative medicine. Emphasizing their diagnostic potential, exosomes serve as carriers disease-specific biomarkers, enabling non-invasive early detection personalized The cargo loading with therapeutic agents presents an innovative strategy targeted drug delivery, minimizing off-target effects optimizing interventions. In medicine, play a crucial role intercellular communication, facilitating tissue regeneration through transmission bioactive molecules. While acknowledging existing challenges standardization scalability, ongoing research efforts aim to refine methodologies address regulatory considerations. summary, this review underscores transformative potential reshaping landscape medical interventions, particular emphasis on cancer,

Language: Английский

Citations

0
Advances in plant-derived vesicle like nanoparticles-based therapies for inflammatory diseases DOI Creative Commons
Zhifei Cheng, Wenbo Lu, Wei Shao

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101052 - 101052

Published: April 1, 2025

Language: Английский

Citations

0
Toward Clarity in Single Extracellular Vesicle Research: Defining the Field and Correcting Missteps DOI Creative Commons
Yun Su,

Wanzhuo He,

Lei Zheng

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Single extracellular vesicle (EV) research holds the potential to revolutionize our understanding of cellular communication and enable breakthroughs in diagnostics therapeutics. However, lack a clear, consensus-driven definition single EV has led methodological inconsistencies, overgeneralized interpretations, and, some cases, misleading claims. In this perspective, we propose framework for defining research, critique current challenges misconceptions field, discuss its implications biomedical applications. We argue that precise experimental design, rigorous validation, interdisciplinary collaboration approaches are needed establish as cornerstone precision medicine.

Language: Английский

Citations

0