Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing
Biosensors,
Год журнала:
2025,
Номер
15(2), С. 100 - 100
Опубликована: Фев. 10, 2025
Understanding
brain
function
requires
advanced
neural
probes
to
monitor
electrical
and
chemical
signaling
across
multiple
timescales
regions.
Microelectrode
arrays
(MEAs)
are
widely
used
record
neurophysiological
activity
various
depths
regions,
providing
single-unit
resolution
for
extended
periods.
Recent
advancements
in
flexible
MEAs,
built
on
micrometer-thick
polymer
substrates,
have
improved
integration
with
tissue
by
mimicking
the
brain's
soft
nature,
reducing
mechanical
trauma
inflammation.
These
flexible,
subcellular-scale
MEAs
can
stable
signals
months,
making
them
ideal
long-term
studies.
In
addition
recording,
been
functionalized
electrochemical
neurotransmitter
detection.
Electroactive
neurotransmitters,
such
as
dopamine,
serotonin,
adenosine,
be
directly
measured
via
methods,
particularly
carbon-based
surfaces.
For
non-electroactive
neurotransmitters
like
acetylcholine,
glutamate,
γ-aminobutyric
acid,
alternative
strategies,
enzyme
immobilization
aptamer-based
recognition,
employed
generate
signals.
This
review
highlights
recent
developments
MEA
fabrication
functionalization
achieve
both
electrophysiological
recordings,
minimizing
sensor
fowling
damage
when
implanted
long-term.
It
covers
multi-time
scale
detection,
development
of
conducting
nanomaterial
composite
coatings
enhance
sensitivity,
incorporation
recognition
carbon
electrodes
MEAs.
Finally,
it
summarizes
strategies
acquire
measurements
from
same
device.
Язык: Английский
Intranasally Delivered Echinacoside Micelles Modulate Mitochondrial Fusion Against Postoperative Cognitive Dysfunction
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 30, 2025
Abstract
The
disruption
of
mitochondrial
homeostasis
in
neurons
accounts
for
the
onset
and
progression
postoperative
cognitive
dysfunction
(POCD).
Echinacoside
(ECH)
can
facilitate
fusion
to
mediate
neuroprotection,
but
its
therapeutic
efficacy
is
greatly
limited
by
inefficient
brain
accumulation
neuronal
delivery.
Herein,
ECH‐encapsulated
micelles
are
constructed
from
copolymer
containing
poly(carboxybetaine
methacrylate)
(PCBMA)
block
phenylboronic
acid
(PBA)‐modified
poly(dimethylamino)ethyl
methacrylate
block,
which
mediates
effective,
brain‐targeted
delivery
via
intranasal
administration.
In
POCD
mice,
efficiently
penetrate
nasal
mucosa
betaine
structure
PCBMA
that
be
recognized
betaine‐GABA
transporter
1
(BGT‐1)
on
epithelial
cells,
followed
into
hippocampus
through
submucosal
olfactory
trigeminal
nerve
pathways.
Subsequently,
internalized
BGT‐1‐mediated
endocytosis.
over‐produced
reactive
oxygen
species
inside
trigger
dissociation
ECH
release,
thereby
inducing
enhance
neuron
survival,
ameliorate
cerebral
microenvironment,
restore
memory
functions.
This
study
reports
a
non‐invasive
strategy
overcome
physiological
barriers
against
drug
renders
profound
implications
treatment.
Язык: Английский
Flexible Semiconductor Electrode for in Vivo Neurochemical Recording in the Brain
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 12, 2025
Abstract
Neural
electrophysiological
and
neurochemical
signals
are
crucial
for
understanding
brain
function
pathophysiology.
Advances
in
neural
interface
technology
have
facilitated
the
capture
of
these
via
implantable
microelectrodes.
However,
significant
challenges
persist
developing
biocompatible
interfaces,
particularly
minimizing
implantation‐induced
tissue
damage
preventing
biofouling.
Conventional
noble
metal
electrodes,
while
widely
used,
limitations
recording
dynamics
can
cause
due
to
their
rigid
nature.
Flexible
semiconductor
electrodes
offer
a
promising
alternative,
unique
photoresponse
biocompatibility,
but
photoelectric
conversion
efficiency
is
still
insufficient,
fabrication
methods
limited.
This
study
introduces
novel
flexible
fiber
electrode
fabricated
wet‐spinning,
incorporating
an
n‐type
ternary
heterojunction
(CdS/CdIn
2
S
4
/ZnIn
)
enhance
efficiency.
demonstrated
uniform
texture,
reproducibility,
stability,
with
superior
biocompatibility.
Leveraging
its
photoresponsive
properties,
developed
real‐time
monitoring
hydrogen
sulfide
levels
epileptic
mice
brains.
work
provides
versatile
platform
signal
acquisition
disease
monitoring,
offering
potential
fundamental
neuroscience
research.
Язык: Английский
Unraveling Multiregional Neural Patterns during Consciousness Transition Using Flexible Microelectrode Arrays Integrated with Neuropixels Chips
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 18, 2025
Consciousness
transitions,
including
awakening
from
anesthesia
or
falling
asleep,
involve
complex
neural
dynamics
across
multiple
brain
regions.
Understanding
these
transitions
requires
simultaneous
and
stable
monitoring
of
large-scale
activity
in
freely
moving
animals.
Here,
a
flexible
microelectrode
array
system
(FlexiPixels
probe)
is
demonstrated
that
integrates
multishank
with
Neuropixels
chips.
This
lightweight
FlexiPixels
probe
enables
long-term
signal
recording
regions
rats
tracking
neuronal
activities
during
consciousness
to
wakefulness
subsequent
sleep
states.
Distinct
state-dependent
firing
patterns
emerge
different
types.
CA1
neurons
show
similar
sleep,
while
DG
exhibit
unique
sensitivity.
These
findings
demonstrate
FlexiPixels'
capabilities
for
multiregion
animals
potential
unravel
region-specific
signatures
studies.
Язык: Английский