Light Triggered “Bacterial Bomb” to Amplify Tumor Pyroptosis
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Abstract
Pyroptosis
is
gaining
attention
for
its
ability
to
activate
the
immune
system.
However,
controlling
induction
of
specific
pyroptotic
tumor
cell
death
effectively
response
a
challenge.
In
this
study,
novel
“bacterial
bomb”
platform
developed
and
designed
precisely
regulate
pyroptosis
using
light
as
trigger,
thereby
optimizing
responses.
The
employs
Escherichia
coli
(Ec)
carrier
introduce
gasdermin
D
(GSDMD)
plasmid
(pGSDMD)
into
Ec
adsorb
photosensitizer
indocyanine
green
(ICG)
on
surface,
termed
Ec‐pGSDMD‐ICG.
ICG
has
photothermal
effects
(PTE)
photodynamic
(PDE).
Under
808
nm
laser
irradiation,
generates
thermal
singlet
oxygen
(
1
O
2
),
leading
rupture
release
pGSDMD,
which
expresses
sufficient
GSDMD
in
cells.
Furthermore,
lipopolysaccharides
(LPS)
caspase
pathways
(caspase‐1
caspase‐11),
cleave
produce
GSDMD‐N,
inducing
Light
triggered
Ec‐pGSDMD‐ICG
not
only
efficiently
induces
cells
with
low
content,
but
also
enhances
moderate
all
while
activating
system
effective
treatment.
This
approach
opens
new
strategies
research
directions
mediated
immunotherapy.
Язык: Английский
The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 54
Опубликована: Апрель 5, 2025
Cancer
is
a
leading
cause
of
mortality
and
morbidity
worldwide.
Nanomaterials,
unique
optical,
magnetic,
electrical
properties
at
the
nanoscale
(1-100
nm),
have
been
engineered
to
improve
drug
capacity,
bioavailability,
specificity
in
cancer
treatment.
These
advancements
address
toxicity
lack
selectivity
conventional
therapies,
enabling
precise
targeting
cells,
tumor
microenvironment,
immune
system.
Among
emerging
approaches,
bacterial
treatment
shows
promise
due
its
natural
ability
target
diverse
therapeutic
mechanisms,
which
nanotechnology
can
further
enhance.
Bacteria-based
delivery
systems
leverage
bacteria's
adaptability
survival
strategies
within
human
body.
Bacterial
derivatives,
such
as
ghosts
(BGs),
extracellular
vesicles
(BEVs),
dietary
toxins,
are
recognized
effective
biological
nanomaterials
capable
carrying
nanoparticles
(NPs).
attracted
increasing
attention
for
their
potential
targeted
NP
This
study
explores
use
various
bacteria
byproducts
vehicles,
highlighting
treating
different
types
cancer.
By
combining
strengths
therapy,
these
innovative
approaches
aim
revolutionize
with
improved
precision
efficacy.
Язык: Английский
Prospects of engineered bacteria-assisted CAR T Cell therapy in gastrointestinal cancers
Oncology Reviews,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 14, 2025
The
high
incidence
and
mortality
rates
associated
with
gastrointestinal
cancers
represent
a
significant
global
health
challenge.
In
recent
years,
CAR
T
cell
therapy
has
emerged
as
promising
immunotherapeutic
approach,
demonstrating
favorable
clinical
outcomes.
However,
the
application
of
traditional
in
faces
numerous
challenges,
including
suppressive
tumor
microenvironment
limitations
anti-tumor
efficacy.
engineered
bacteria
offers
novel
strategy
to
enhance
by
modulating
boosting
immune
responses,
potentially
leading
improved
therapeutic
This
review
synthesizes
current
research
advancements
related
bacteria-assisted
cancers,
exploring
its
underlying
mechanisms,
applications,
future
developmental
directions.
Язык: Английский
Bioactive polydopamine nanomedicines-assisted cancer immunotherapy
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101864 - 101864
Опубликована: Май 1, 2025
Язык: Английский
Bacteria and Carcinogenesis and the Management of Cancer: A Narrative Review
Pathogens,
Год журнала:
2025,
Номер
14(5), С. 509 - 509
Опубликована: Май 21, 2025
There
is
a
widely
known
relationship
between
certain
microbes
and
cancer
progression.
For
instance,
Helicobacter
pylori
associated
with
the
occurrence
of
gastric
cancer,
while
HPV
cervical
head
neck
cancers.
Recent
studies
have
uncovered
novel
important
associations
bacterial
presence
tumor
formation
treatment
response.
Apart
from
influence
intestinal
microbiome
on
local
activity
bacteria
affects
disease
properties
as
well.
Bacteria
can
localize
within
tumors
in
less
vascularized
niches.
Their
mediates
signaling
pathways,
which
contribute
to
tumorigenesis.
Furthermore,
they
affect
composition
microenvironment,
highly
complex
structure
composed
immunoregulatory
cells
secreted
inflammatory
mediators.
Recently,
researchers
analyzed
develop
anticancer
strategies.
The
aim
this
review
discuss
latest
findings
regarding
relationships
that
could
be
used
kill
cells.
Язык: Английский