Light Triggered “Bacterial Bomb” to Amplify Tumor Pyroptosis

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract Pyroptosis is gaining attention for its ability to activate the immune system. However, controlling induction of specific pyroptotic tumor cell death effectively response a challenge. In this study, novel “bacterial bomb” platform developed and designed precisely regulate pyroptosis using light as trigger, thereby optimizing responses. The employs Escherichia coli (Ec) carrier introduce gasdermin D (GSDMD) plasmid (pGSDMD) into Ec adsorb photosensitizer indocyanine green (ICG) on surface, termed Ec‐pGSDMD‐ICG. ICG has photothermal effects (PTE) photodynamic (PDE). Under 808 nm laser irradiation, generates thermal singlet oxygen ( 1 O 2 ), leading rupture release pGSDMD, which expresses sufficient GSDMD in cells. Furthermore, lipopolysaccharides (LPS) caspase pathways (caspase‐1 caspase‐11), cleave produce GSDMD‐N, inducing Light triggered Ec‐pGSDMD‐ICG not only efficiently induces cells with low content, but also enhances moderate all while activating system effective treatment. This approach opens new strategies research directions mediated immunotherapy.

Language: Английский

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The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 54

Published: April 5, 2025

Cancer is a leading cause of mortality and morbidity worldwide. Nanomaterials, unique optical, magnetic, electrical properties at the nanoscale (1-100 nm), have been engineered to improve drug capacity, bioavailability, specificity in cancer treatment. These advancements address toxicity lack selectivity conventional therapies, enabling precise targeting cells, tumor microenvironment, immune system. Among emerging approaches, bacterial treatment shows promise due its natural ability target diverse therapeutic mechanisms, which nanotechnology can further enhance. Bacteria-based delivery systems leverage bacteria's adaptability survival strategies within human body. Bacterial derivatives, such as ghosts (BGs), extracellular vesicles (BEVs), dietary toxins, are recognized effective biological nanomaterials capable carrying nanoparticles (NPs). attracted increasing attention for their potential targeted NP This study explores use various bacteria byproducts vehicles, highlighting treating different types cancer. By combining strengths therapy, these innovative approaches aim revolutionize with improved precision efficacy.

Language: Английский

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Prospects of engineered bacteria-assisted CAR T Cell therapy in gastrointestinal cancers

Oncology Reviews, Journal Year: 2025, Volume and Issue: 19

Published: April 14, 2025

The high incidence and mortality rates associated with gastrointestinal cancers represent a significant global health challenge. In recent years, CAR T cell therapy has emerged as promising immunotherapeutic approach, demonstrating favorable clinical outcomes. However, the application of traditional in faces numerous challenges, including suppressive tumor microenvironment limitations anti-tumor efficacy. engineered bacteria offers novel strategy to enhance by modulating boosting immune responses, potentially leading improved therapeutic This review synthesizes current research advancements related bacteria-assisted cancers, exploring its underlying mechanisms, applications, future developmental directions.

Language: Английский

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Bioactive polydopamine nanomedicines-assisted cancer immunotherapy

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101864 - 101864

Published: May 1, 2025

Language: Английский

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Bacteria and Carcinogenesis and the Management of Cancer: A Narrative Review

Pathogens, Journal Year: 2025, Volume and Issue: 14(5), P. 509 - 509

Published: May 21, 2025

There is a widely known relationship between certain microbes and cancer progression. For instance, Helicobacter pylori associated with the occurrence of gastric cancer, while HPV cervical head neck cancers. Recent studies have uncovered novel important associations bacterial presence tumor formation treatment response. Apart from influence intestinal microbiome on local activity bacteria affects disease properties as well. Bacteria can localize within tumors in less vascularized niches. Their mediates signaling pathways, which contribute to tumorigenesis. Furthermore, they affect composition microenvironment, highly complex structure composed immunoregulatory cells secreted inflammatory mediators. Recently, researchers analyzed develop anticancer strategies. The aim this review discuss latest findings regarding relationships that could be used kill cells.

Language: Английский

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