Colloids and Interfaces,
Год журнала:
2021,
Номер
5(1), С. 18 - 18
Опубликована: Март 18, 2021
The
stratum
corneum,
the
most
superficial
layer
of
skin,
protects
body
against
environmental
hazards
and
presents
a
highly
selective
barrier
for
passage
drugs
cosmetic
products
deeper
into
skin
across
skin.
Nanomaterials
can
effectively
increase
permeation
active
molecules
corneum
enable
their
penetration
layers,
often
by
interacting
with
creating
distinct
sites
elevated
local
concentration,
acting
as
reservoirs.
flux
from
these
reservoirs
be
either
limited
to
underlying
layers
(for
topical
drug
cosmeceutical
delivery)
or
extended
all
sublayers
epidermis
blood
vessels
dermis
transdermal
delivery).
type
nanocarrier
physicochemical
nature
substance
are
among
factors
that
determine
final
pattern
stability
penetrant
in
cutaneous
environment.
widely
employed
types
nanomaterials
dermal
applications
include
solid
lipid
nanoparticles,
nanovesicular
carriers,
microemulsions,
nanoemulsions,
polymeric
nanoparticles.
recent
advances
area
nanomaterial-assisted
delivery
highlighted
this
review.
ACS Applied Nano Materials,
Год журнала:
2019,
Номер
2(11), С. 7393 - 7408
Опубликована: Окт. 14, 2019
Malignant
melanoma
is
the
utmost
severe
form
of
skin
cancer,
causing
vast
majority
deaths
related
to
cancer
in
humans.
Although
treatable
at
its
early
stages
localized
forms,
metastatic
remains
a
therapeutic
challenge
with
dramatically
increased
incidence
past
few
years.
In
addition,
opportunistic
pathogens
can
provoke
infections
leading
ulceration
cutaneous
melanoma.
Herein,
we
designed
and
synthesized
hybrid
hydrogels
made
silver
nanoparticles
(AgNPs)
embedded
carboxymethylcellulose
(CMC)
polymer
cross-linked
networks
conjugated
doxorubicin
(DOX),
anticancer
drug.
This
system
was
by
green
process,
using
single-pot
situ
reduction
Ag+
CMC
polymer,
which
also
acted
as
capping
ligand,
followed
electrostatic
conjugation
DOX,
forming
colloidal
nanocomplexes
aqueous
media.
These
nanoconjugates
were
chemically
citric
acid
(CA)
under
mild
pH
temperature
conditions.
The
results
demonstrated
effective
nucleation
stabilization
spherical
AgNPs
nanocolloids,
uniform
size
distribution
(d
∼
10
nm).
physicochemical
properties
(AgNP@CMC-DOX)
affected
degree
carboxymethylation
(DS
=
0.8
1.2)
development
supramolecular
nanocolloidal
dispersions.
nanohybrids
predominantly
stabilized
interactions
between
carboxylate
groups
(anionic,
CMC)
amino
(cationic,
DOX),
vesicle-like
nanosystems.
AgNP@CMC-DOX
nanostructures
producing
(AgNP@CMC-DOX-CA),
gel
fraction
swelling
dependent
on
DS.
Consequently,
these
hybrids
tuned
DOX
intracellular
kinetics
vitro,
evidencing
synergistic
effect
for
killing
cells.
Moreover,
nanocomposites
proved
antimicrobial
activity
against
Gram-positive
Gram-negative
bacterias.
Thus,
an
innovative
platform
developed
based
nanoparticle–polysaccharide–drug
antibacterial
be
applied
weapon
arsenal
via
topical
drug
delivery
chemotherapy.
Advanced Electronic Materials,
Год журнала:
2019,
Номер
6(1)
Опубликована: Ноя. 20, 2019
Abstract
Soft,
wet,
and
biocompatible
hydrogels
have
emerged
as
promising
materials
for
flexible
stretchable
electronics
owing
to
their
similar
properties
with
biological
tissues.
However,
most
existing
conductive
used
hydrogel‐based
drawbacks
such
poor
biocompatibility,
low
conductivity,
and/or
high
mechanical
mismatch
soft
hydrogels.
In
this
work,
direct
patterning
of
nontoxic
highly
liquid
metal
(LM)
on
is
reported
without
mismatches.
The
achieved
by
coating
LM
dispersed
magnetic
microparticles
the
wet
hydrogel
surface
using
a
magnet.
High‐resolution
patterns
microscale
linewidths
can
be
created
assistance
shadow
mask
fabricated
in
situ
digital
laser
cutting.
Mechanical
electrical
self‐healing
are
simultaneously
taking
advantage
hydrogen
bonds
polyvinyl
alcohol
network
merging
LM.
A
few
applications
LM‐based
wearable
sensing,
wireless
communication,
actuating
also
demonstrated.
Molecules,
Год журнала:
2020,
Номер
25(24), С. 5795 - 5795
Опубликована: Дек. 8, 2020
Hydrogels
(HGs),
as
three-dimensional
structures,
are
widely
used
in
modern
medicine,
including
regenerative
medicine.
The
use
of
HGs
wound
treatment
and
tissue
engineering
is
a
rapidly
developing
sector
unique
properties
allow
researchers
to
easily
modify
them
maximize
their
potential.
Herein,
we
describe
the
physicochemical
HGs,
which
determine
subsequent
applications
medicine
engineering.
Examples
chemical
modifications
described
based
on
latest
scientific
reports.
Colloids and Interfaces,
Год журнала:
2021,
Номер
5(1), С. 18 - 18
Опубликована: Март 18, 2021
The
stratum
corneum,
the
most
superficial
layer
of
skin,
protects
body
against
environmental
hazards
and
presents
a
highly
selective
barrier
for
passage
drugs
cosmetic
products
deeper
into
skin
across
skin.
Nanomaterials
can
effectively
increase
permeation
active
molecules
corneum
enable
their
penetration
layers,
often
by
interacting
with
creating
distinct
sites
elevated
local
concentration,
acting
as
reservoirs.
flux
from
these
reservoirs
be
either
limited
to
underlying
layers
(for
topical
drug
cosmeceutical
delivery)
or
extended
all
sublayers
epidermis
blood
vessels
dermis
transdermal
delivery).
type
nanocarrier
physicochemical
nature
substance
are
among
factors
that
determine
final
pattern
stability
penetrant
in
cutaneous
environment.
widely
employed
types
nanomaterials
dermal
applications
include
solid
lipid
nanoparticles,
nanovesicular
carriers,
microemulsions,
nanoemulsions,
polymeric
nanoparticles.
recent
advances
area
nanomaterial-assisted
delivery
highlighted
this
review.
