Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2021, Номер 165, С. 127 - 148

Опубликована: Май 13, 2021

Язык: Английский

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Polymeric Nanoparticles for Delivery of Natural Bioactive Agents: Recent Advances and Challenges

Polymers, Год журнала: 2023, Номер 15(5), С. 1123 - 1123

Опубликована: Фев. 23, 2023

In the last few decades, several natural bioactive agents have been widely utilized in treatment and prevention of many diseases owing to their unique versatile therapeutic effects, including antioxidant, anti-inflammatory, anticancer, neuroprotective action. However, poor aqueous solubility, bioavailability, low GIT stability, extensive metabolism as well short duration action are most shortfalls hampering biomedical/pharmaceutical applications. Different drug delivery platforms developed this regard, a captivating tool has fabrication nanocarriers. particular, polymeric nanoparticles were reported offer proficient various with good entrapment potential an efficiently controlled release, improved fascinating efficacy. addition, surface decoration polymer functionalization opened door improving characteristics alleviating toxicity. Herein, review state knowledge on loaded is presented. The focuses frequently used materials corresponding methods fabrication, needs such systems for agents, literature, role functionalization, hybrid systems, stimuli-responsive overcoming system drawbacks. This exploration may thorough idea viewing candidate challenges combating tools overcome any hurdles.

Язык: Английский

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Nanocarriers for Skin Applications: Where Do We Stand?

Angewandte Chemie International Edition, Год журнала: 2021, Номер 61(3)

Опубликована: Сен. 6, 2021

Skin penetration of active molecules for treatment diverse diseases is a major field research owing to the advantages associated with skin like easy accessibility, reduced systemic-derived side effects, and increased therapeutic efficacy. Despite these advantages, dermal drug delivery generally challenging due low permeability therapeutics. Although various methods have been developed improve permeation therapeutics, they are usually aggressive could lead irreversible damage stratum corneum. Nanosized carrier systems represent an alternative approach current technologies, minimal natural barrier function skin. In this Review, use nanoparticles deliver molecules, genetic material, vaccines into discussed. addition, nanotoxicology studies recent clinical development highlighted shed light on their potential undergo market translation.

Язык: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

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Injectable self-healing cellulose hydrogel based on host-guest interactions and acylhydrazone bonds for sustained cancer therapy

Acta Biomaterialia, Год журнала: 2022, Номер 141, С. 102 - 113

Опубликована: Янв. 3, 2022

Язык: Английский

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Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 314, С. 102871 - 102871

Опубликована: Март 9, 2023

Nanotechnological drug delivery platforms represent a new paradigm for cancer therapeutics as they improve the pharmacokinetic profile and distribution of chemotherapeutic agents over conventional formulations. Among nanoparticles, lipid-based nanoplatforms possessing lipid core, that is, lipid-core nanoparticles (LCNPs), have gained increasing interest due to properties such high solubilizing potential, versatility, biocompatibility, biodegradability. However, wide spectrum morphologies types LCNPs, there is lack consensus regarding their terminology classification. According current state-of-the-art in this critical review, LCNPs are defined classified based on state lipidic components liquid (LLNs). These include nanoemulsions (LNEs) nanocapsules (LNCs), solid (SLNs) nanostructured nanocarriers (NLCs). In addition, we present comprehensive comparative description methods employed preparation, routes administration fundamental role physicochemical efficient antitumoral drug-delivery application. Market available clinical trials preclinical vivo studies promising potential treatments different pathologies summarized.

Язык: Английский

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Nanotechnology-empowered strategies in treatment of skin cancer

Environmental Research, Год журнала: 2023, Номер 235, С. 116649 - 116649

Опубликована: Июль 13, 2023

Язык: Английский

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MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

Small, Год журнала: 2024, Номер 20(30)

Опубликована: Март 7, 2024

Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials

Язык: Английский

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Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(12), С. 5161 - 5180

Опубликована: Авг. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Язык: Английский

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A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

ACS Omega, Год журнала: 2024, Номер 9(9), С. 10030 - 10048

Опубликована: Фев. 22, 2024

Skin cancer (SC) poses a global threat to the healthcare system and is expected increase significantly over next two decades if not diagnosed at an early stage. Early diagnosis crucial for successful treatment, as disease becomes more challenging cure it progresses. However, identifying new drugs, achieving clinical success, overcoming drug resistance remain significant challenges. To overcome these obstacles provide effective understand causes of skin cancer, how cells grow divide, factors that affect cell growth, occurs. In this review, we have explained various therapeutic approaches SC treatment via ligands, targeted photosensitizers, natural synthetic drugs SC, epigenetic approach management melanoma, photodynamic therapy, therapy BRAF-mutated melanoma. This article also provides detailed summary are in managing melanoma reducing occurrence stages focuses on current status future prospects therapies available cancer.

Язык: Английский

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