Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications

Chemical Society Reviews, Год журнала: 2020, Номер 49(2), С. 433 - 464

Опубликована: Янв. 1, 2020

Hydrogels are a unique class of polymeric materials that possess an interconnected porous network across various length scales from nano- to macroscopic dimensions and exhibit remarkable structure-derived properties, including high surface area, accommodating matrix, inherent flexibility, controllable mechanical strength, excellent biocompatibility. Strong robust adhesion between hydrogels substrates is highly desirable for their integration into subsequent performance in biomedical devices systems. However, the adhesive behavior severely weakened by large amount water interacts with groups reducing interfacial interactions. The challenges developing tough hydrogel-solid interfaces bonding wet conditions analogous problems solved marine organisms. Inspired mussel adhesion, variety catechol-functionalized have been developed, opening door design multi-functional platforms. This review structured give comprehensive overview starting fundamental underwater followed synthetic approaches fabrication techniques, as well characterization methods, finally practical applications tissue repair regeneration, antifouling antimicrobial applications, drug delivery, cell encapsulation delivery. Insights on these topics will provide rational guidelines using nature's blueprints develop hydrogel advanced functionalities uncompromised properties.

Язык: Английский

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Near-Infrared Light-Triggered Nitric-Oxide-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy for Biofilm Elimination

ACS Nano, Год журнала: 2020, Номер 14(3), С. 3546 - 3562

Опубликована: Фев. 18, 2020

Photothermal treatment (PTT) involving a combination of therapeutic modalities recently emerged as an efficient alternative for combating biofilm. However, PTT-related local high temperature may destroy the surrounding healthy tissues. Herein, we present all-in-one phototherapeutic nanoplatform consisting l-arginine (l-Arg), indocyanine green (ICG), and mesoporous polydopamine (MPDA), namely, AI-MPDA, to eliminate already-formed The fabrication process included surface modification MPDA with l-Arg further adsorption ICG via π–π stacking. Under near-infrared (NIR) exposure, AI-MPDA not only generated heat but also produced reactive oxygen species, causing cascade catalysis release nitric oxide (NO). NIR irradiation, biofilm elimination was attributed NO-enhanced photodynamic therapy low-temperature PTT (≤45 °C). Notably, NIR-triggered strategy resulted in severe destruction bacterial membranes. displayed good cytocompatibility. NIR-irradiated nanoparticles prevented colonization realized rapid recovery infected wounds. More importantly, platform effective efficiency around 100% abscess formation model. Overall, this provides reliable tool biofilms clinical applications.

Язык: Английский

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Molecular Imprinting: Green Perspectives and Strategies

Advanced Materials, Год журнала: 2021, Номер 33(30)

Опубликована: Июнь 18, 2021

Abstract Advances in revolutionary technologies pose new challenges for human life; response to them, global responsibility is pushing modern toward greener pathways. Molecular imprinting technology (MIT) a multidisciplinary mimic simulating the specific binding principle of enzymes substrates or antigens antibodies; along with its rapid progress and wide applications, MIT faces challenge complying green sustainable development requirements. With identification environmental risks associated unsustainable MIT, aspect termed has emerged developed. However, so far, no clear definition been provided appraise MIT. Herein, implementation process chemistry demonstrated mnemonic device form an acronym, GREENIFICATION, proposed present principles. The entire greenificated surveyed, including element choice, polymerization implementation, energy input, strategies, waste treatment, recovery, as well impacts these processes on operator health environment. Moreover, assistance upgraded instrumentation deploying goals considered. Finally, future perspectives are presented provide more complete picture road map pave way further development.

Язык: Английский

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Highly Stretchable, Adhesive, Biocompatible, and Antibacterial Hydrogel Dressings for Wound Healing

Advanced Science, Год журнала: 2021, Номер 8(8)

Опубликована: Март 5, 2021

Treatment of wounds in special areas is challenging due to inevitable movements and difficult fixation. Common cotton gauze suffers from incomplete joint surface coverage, confinement movement, lack antibacterial function, frequent replacements. Hydrogels have been considered as good candidates for wound dressing because their flexibility biocompatibility. Nevertheless, the adhesive, mechanical, properties conventional hydrogels are not satisfactory. Herein, cationic polyelectrolyte brushes grafted bacterial cellulose (BC) nanofibers introduced into polydopamine/polyacrylamide hydrogels. The 1D polymer rigid BC backbones enhance mechanical property hydrogels, realizing high tensile strength (21-51 kPa), large strain (899-1047%), ideal compressive property. Positively charged quaternary ammonium groups tethered provide long-lasting promote crawling proliferation negatively epidermis cells. Moreover, rich catechol capable adhering various surfaces, meeting adhesive demand movement areas. With above merits, demonstrate less inflammatory response faster healing speed vivo on rats. Therefore, multifunctional show stable covering, little displacement, antibacteria, fast healing, demonstrating promise dressing.

Язык: Английский

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Год журнала: 2021, Номер 15(12), С. 18895 - 18930

Опубликована: Дек. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Язык: Английский

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Metal‐Containing Polydopamine Nanomaterials: Catalysis, Energy, and Theranostics

Small, Год журнала: 2020, Номер 16(18)

Опубликована: Март 26, 2020

Polydopamine (PDA) is a major type of artificial melanin material with many interesting properties such as antioxidant activity, free-radical scavenging, high photothermal conversion efficiency, and strong metal-ion chelation. The affinity PDA to wide range metals/metal ions has offered new class functional metal-containing polydopamine (MPDA) nanomaterials promising functions extensive applications. Understanding controlling the metal coordination environment vital achieve desirable for which materials can be exploited. MPDA metal/metal active are reviewed, including their synthesis applications in catalysis, batteries, solar cells, capacitors, medical imaging, cancer therapy, antifouling, antibacterial coating. current trends, limitations, future directions this area also explored.

Язык: Английский

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Stimuli-responsive polydopamine-based smart materials

Chemical Society Reviews, Год журнала: 2021, Номер 50(14), С. 8319 - 8343

Опубликована: Янв. 1, 2021

This review provides in-depth insight into the structural engineering of PDA-based materials to enhance their responsive feature and use them in construction stimuli-responsive smart materials.

Язык: Английский

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Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Theranostics, Год журнала: 2021, Номер 12(1), С. 434 - 458

Опубликована: Дек. 15, 2021

Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to because of powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity tumors. Photodynamic therapy (PDT) can not only directly kill cells, but also elicit immunogenic cell death (ICD), providing antitumor immunity. Unfortunately, limitations from the inherent nature complex TME significantly reduce efficiency PDT. Recently, smart nanomedicine-based strategies could subtly modulate pharmacokinetics therapeutic compounds optimize both PDT immunotherapy, resulting an improved effect. Here, emerging nanomedicines for PDT-driven cancer are reviewed, including hypoxia-reversed nanomedicines, nanosized metal-organic frameworks, subcellular targeted nanoparticles (NPs). Moreover, we highlight synergistic nanotherapeutics used amplify immune responses combined against Lastly, challenges future expectations field discussed.

Язык: Английский

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Polyphenol scaffolds in tissue engineering

Materials Horizons, Год журнала: 2020, Номер 8(1), С. 145 - 167

Опубликована: Сен. 17, 2020

Polyphenols are a class of ubiquitous compounds distributed in nature, with fascinating inherent biocompatible, bioadhesive, antioxidant, and antibacterial properties. The unique polyphenolic structures based on catechol or pyrogallol moieties allow for strong non-covalent interactions (e.g., multiple hydrogen bonding, electrostatic, cation-π interactions) as well covalent Michael addition/Schiff-base reaction, radical coupling dynamic coordination boronate metal ions). This review article provides an overview the polyphenol-based scaffolds including hydrogels, films, nanofibers that have emerged from chemical functional signatures during past years. A full description structure-function relationships terms their utilization wound healing, bone regeneration, electroactive tissue engineering is also carefully discussed, which may pave path towards rational design facile preparation next-generation polyphenol applications.

Язык: Английский

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Label-free SERS detection of Raman-Inactive protein biomarkers by Raman reporter indicator: Toward ultrasensitivity and universality

Biosensors and Bioelectronics, Год журнала: 2020, Номер 174, С. 112825 - 112825

Опубликована: Ноя. 19, 2020

Язык: Английский

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