CuS-NPs, GQD, MSN-NPs and Doxorubicin: An excellent nano-compound for cancer treatment by chemo-photodynamic therapy

Journal of Alloys and Compounds, Год журнала: 2024, Номер unknown, С. 173624 - 173624

Опубликована: Янв. 1, 2024

Язык: Английский

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Third-Generation Anticancer Photodynamic Therapy Systems Based on Star-like Anionic Polyacrylamide Polymer, Gold Nanoparticles, and Temoporfin Photosensitizer

Molecules, Год журнала: 2024, Номер 29(10), С. 2224 - 2224

Опубликована: Май 9, 2024

Photodynamic therapy (PDT) is a non-invasive anticancer treatment that uses special photosensitizer molecules (PS) to generate singlet oxygen and other reactive species (ROS) in tissue under excitation with red or infrared light. Though the method has been known for decades, it become more popular recently development of new efficient organic dyes LED light sources. Here we introduce ternary nanocomposite: water-soluble star-like polymer/gold nanoparticles (AuNP)/temoporfin PS, which can be considered as third-generation PDT system. AuNPs were synthesized situ inside polymer molecules, latter then loaded PS an aqueous solution. The applied synthesis allows precise control size architecture well concentration components. Dynamic scattering confirmed formation isolated particles (120 nm diameter) incorporated shell. Absorption photoluminescence spectroscopies revealed optimal concentrations components simultaneously reduce side effects dark toxicity enhance generation increase cancer cell mortality. Here, report on optical properties system detailed mechanisms observed enhancement phototherapeutic effect. Combinations gold allow significant effect ROS due surface plasmonic resonance latter, while application biocompatible vehicle dextran core anionic polyacrylamide arms better local integration targeted delivery cells. In this study, demonstrate, proof concept, successful developed vitro triple-negative breast cells irradiation low-power lamp (660 nm). We consider nanocomposite promising types cancer.

Язык: Английский

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Advances in Nanotherapeutics for Tumor Treatment by Targeting Calcium Overload

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114190 - 114190

Опубликована: Сен. 2, 2024

Язык: Английский

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A hydrogel based on Fe(ii)-GMP demonstrates tunable emission, self-healing mechanical strength and Fenton chemistry-mediated notable antibacterial properties

Nanoscale, Год журнала: 2024, Номер 16(27), С. 13050 - 13060

Опубликована: Янв. 1, 2024

Supramolecular hydrogels serve as an excellent platform to enable in situ reactive oxygen species (ROS) generation while maintaining controlled localized conditions, thereby mitigating cytotoxicity. Herein, we demonstrate hydrogel formation using guanosine-5'-monophosphate (GMP) with tetra(4-carboxylphenyl) ethylene (1) exhibit aggregation-induced emission (AIE) and tunable mechanical strength the presence of divalent metal ions such Ca2+, Mg2+, Fe2+. The addition leads structural transformation metallogels (M-1GMP). Furthermore, incorporation Fe2+ into (Fe-1GMP) promotes Fenton reaction that could be upregulated upon adding ascorbic acid (AA), demonstrating antibacterial efficacy via ROS generation. In vitro studies on AA-loaded Fe-1GMP bacterial killing against E. coli, S. aureus vancomycin-resistant enterococci (VRE) strains. Finally, vivo involving topical administration Balb/c mice skin infections further suggest potential hydrogel. Taken together, its unique combination tunability, capability can used for biomedical applications, particularly wound healing infection control.

Язык: Английский

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The Latest Look at PDT and Immune Checkpoints

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(7), С. 7239 - 7257

Опубликована: Июль 8, 2024

Photodynamic therapy (PDT) can not only directly eliminate cancer cells, but also stimulate antitumor immune responses. It affects the expression of checkpoints. The purpose this review is to collect, analyze, and summarize recent news about PDT checkpoints, along with their inhibitors, identify future research directions that may enhance effectiveness approach. A search for articles published between January 2023 March 2024 was conducted in PubMed/MEDLINE. Eligibility criteria were as follows: (1) papers describing (2) original papers, (3) new reports field (4) both vitro vivo papers. Exclusion included written a language other than Polish or English, before 2023. 24 data on checkpoints have been since These information effects attempts associate ICI molecules modulate improve immunosuppressive environment tumor, resolve PDT-related problems. They focused development nanoparticles delivery photosensitizers drugs selectively tumor. effect level associated activity system has fully elucidated further, area are divergent, indicating complexity interaction system. PDT-based strategies shown beneficial utility enhancing induction response by participating triggering immunogenic cell death, exposure tumor antigens, release various alarm signals together promote activation dendritic cells components demonstrated, result induced therapy. enables multifaceted regulation tumor’s environment, which potential achieve better efficacy. current presented evidence PDT’s ability association ICIs inducing an effective against cells. However, these studies at early stage many more observations need be made confirm indicated contribute further strategies.

Язык: Английский

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