ACS Omega,
Год журнала:
2023,
Номер
8(46), С. 44312 - 44327
Опубликована: Ноя. 10, 2023
The
resistance
of
microorganisms
to
antimicrobials
has
endangered
the
health
many
people
across
world.
Overcoming
problem
will
require
invention
molecules
with
a
new
mechanism
action
so
that
no
cross-resistance
existing
therapies
occurs.
Because
their
powerful
antibacterial
activity
against
wide
spectrum
Gram-positive
and
Gram-negative
bacterial
strains,
heterocyclic
compounds
are
appealing
candidates
for
medicinal
chemists.
In
this
regard,
as
unique
hybrid
compounds,
we
synthesized
novel
family
bis-thiazoles
linked
quinoxaline
or
thienothiophene
via
2-phenoxy-N-arylacetamide
moiety.
target
were
by
reacting
relevant
bis(α-haloketones)
corresponding
thiosemicarbazones
in
EtOH
at
reflux
few
drops
TEA.
Under
comparable
reaction
conditions,
isomeric
bis(thiazoles)
appropriate
bis(thiosemicarbazone)
respective
α-haloketones.
structures
confirmed
using
elements
spectral
data.
All
tested
vitro.
With
an
inhibitory
zone
width
12
mm,
compound
12a
had
same
reference
medication
tobramycin
Staphylococcus
aureus.
Compound
12b
showed
20
mg/mL
minimum
concentration
(MIC)
Bacillus
subtilis.
Some
molecular
docking
two
proteins
(dihydrofolate
reductase
tyrosyl-tRNA
synthetase).
Journal of Enzyme Inhibition and Medicinal Chemistry,
Год журнала:
2023,
Номер
38(1)
Опубликована: Авг. 7, 2023
Hexahydroquinoline
(HHQ)
scaffold
was
constructed
and
recruited
for
development
of
new
series
anticancer
agents.
Thirty-two
compounds
were
synthesised
where
x-ray
crystallography
performed
to
confirm
enantiomerism.
Thirteen
showed
moderate
good
activity
against
NCI
60
cancer
cell
lines,
with
GI
%
mean
up
74%
Arabian Journal of Chemistry,
Год журнала:
2023,
Номер
16(12), С. 105291 - 105291
Опубликована: Сен. 26, 2023
Ferula
ferulaeoides
(Steud.)
Korovin
is
a
traditional
ethnopharmacological
plant
used
for
lump
elimination
and
as
spice,
especially
in
places
like
India.
It
has
also
been
employed
the
livestock
food
industries.
This
investigation
aimed
to
explore
anti-tumor
mechanisms
of
ethyl
acetate
extract
fractions
dried
roots
(FF-EtOAc)
on
esophageal
cancer
(EC)
cells.
Furthermore,
it
was
hypothesized
that
FF-EtOAc
could
inhibit
EC
cells
growths
by
inducing
apoptosis.
In
time-
dose-dependent
manner,
considerably
reduced
number
migrating
And
inhibited
growth
vivo,
less
toxic
nude
mice.
terms
anticancer
mechanism,
findings
revealed
activating
mitochondrial
signaling
pathways
PI3K/Akt/Bad
pathways.
Through
both
vitro
vivo
experiments,
significantly
exhibited
anti-esophageal
activity.
The
anti-EC
activity
may
be
due
activation
apoptotic
